Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep240 | Calcium and Vitamin D metabolism | ECE2015

Recalcitrant hypocalcaemia in a patient with post-thyroidectomy hypoparathyroidism and roux-en-y gastric bypass

Miguel Gonzalo Allo , Fernandez Elena Garcia , Librizzi Soledad , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: Roux-en-Y gastric bypass (RYGB) places patients at an increased risk of hypocalcemia due to the reduction in calcium absorption (because the procedure bypasses the duodenum and jejunum) and vitamin D deficiency. Subsequent thyroid surgery increases the risk of severe hypocalcemia due to potential post-operative hypoparathyroidism. Only a few cases have been published before of this kind of treatment-challenging hypocalcaemia.Case report: We...

ea0037ep272 | Calcium and Vitamin D metabolism | ECE2015

Cinacalcet remains effective in primary hyperparathyroidism after 4 years of treatment

Luque-Fernandez Ines , Vall Florentino Del , Luque Alessandra , Vicente Almudena , Sastre Julia , Marco Amparo

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism in patients who are unable to undergo parathyroidectomy: do not accept surgery, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that includes nine patients with primary hyperparathyroidism who have completed at least 48 months of treatment with cinacalcet (seven patients refusal to par...

ea0037ep395 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Unawareness hypoglycaemia in patients with type 1 diabetes mellitus: prevalence and predictive clinical characteristics

Muros Mariola Mendez , Lloclla Eyvee Arturo Cuellar , Perez Fernando Garcia , de Pinillos Gordillo Guillermo Martinez , Fernandez-Ladreda Mariana Tome , Quiros Munoz Juan Manuel Garciade , Pena Jose Ignacio Fernandez , Lopez Jose Ignacio Fernandez , Fernandez Margarita Rivas , Amat Juana Magdalena Hidalgo , Garcia Santiago Duran , Leon Maria Victoria Cozar

Background: The prevalence of unawareness hypoglycaemia in patients with type 1 diabetes mellitus (T1DM) is uncertain. This study aims to determine its prevalence and predictive clinical characteristics with greater precision.Methods: Prospective study. 128 patients were recruited between September 2013 and January 2014. Awareness of hypoglycaemia was assessed using the ‘Clarke’ questionnaire and was classified into two groups, depending on the...

ea0037ep436 | Diabetes (complications & therapy) | ECE2015

Stroke in prediabetic patients

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Moreno-Moreno Paloma , Garcia-Ruiz Rosa Maria , Gonzalez-Pereira Carolina

Objective: To describe the clinical characteristics of stroke in patients with prediabetes mellitus (pre-DM) and to compare them with DM and non-DM patient characteristics.Methods: Retrospective analysis of a prospective series of acute stroke patients. Demographic and clinical characteristics were compared among the three groups, along with outcome data. Stroke severity was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).<p cla...

ea0037ep459 | Diabetes (complications &amp; therapy) | ECE2015

Risk factors, aetiology, and prognosis in patients with ischaemic stroke and diabetes mellitus

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Moreno-Moreno Paloma , Garcia-Ruiz Rosa M , Gonzalez-Pereira Carolina

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale)....

ea0037ep484 | Diabetes (complications &amp; therapy) | ECE2015

Association between peripheral vascular disease and other macrovascular and microvascular complications in diabetic patients

Miguel Gonzalo Allo , Fernandez Elena Garcia , Bracamonte Milagros Sierra , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of macro and microvascular disease. Previous studies suggest a link between microvascular and macrovascular complications in diabetes. However, just a few studies have investigated whether the presence of peripheral vascular disease (PVD) is associated with other macrovascular and microvascular complications in diabetes patients. So, this was the aim of our study.Patient...

ea0037ep485 | Diabetes (complications &amp; therapy) | ECE2015

Diabetic kidney disease and its association with macrovascular disease in diabetic patients

Fernandez Elena Garcia , Miguel Gonzalo Allo , Villa Lucas Arroyave , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Introduction: It is well known that diabetes confers a substantial burden of macrovascular disease. However, just a few studies have investigated the association between diabetic kidney disease (DKD) and cardiovascular disease. The purpose of this study is to investigate whether the presence of DKD is associated with macrovascular disease in diabetic patients.Patients and methods: 98 diabetic patients (48 males/50 females) were included in the study. DKD...

ea0037ep668 | Pituitary: basic and neuroendocrinology | ECE2015

Radio-induced meningioma: a long-term consequence of pituitary radiotherapy

Paramo-Fernandez Concepcion , Lopez-Vazquez Yolanda , Barragans Gloria , Martinez Angel , Lago Javier , Gomara Susana

Long-term sequels of pituitary radiotherapy include hypopituitarism, optic nerve atrophy, sensorineural hearing loss, neurocognitive impairment and second intracranial neoplasms, the meningioma being the most frequent. The cumulative incidence of second cerebral tumours within 20 years of the radiation is 2% and, unlike its primary forms, they show a more aggressive atypical histology, and the age of appearance varies depending on the latency time, which in its turn is proport...

ea0037ep767 | Pituitary: clinical | ECE2015

Response to pasireotide in an acromegalic patient with resistance to conventional medical treatment

Saenz Maria Sonia Gaztambide , Fernandez Pedro Gonzalez , Unanue Ihintza Larranaga , Rodriguez Maria Dolores Moure

Introduction: Surgery is the primary therapy in most acromelagic patients. When persistent disease is observed, adjuvant medical therapy is used. Pasireotide is a somatostatin analogue (SSA) not approved for acromegaly therapy yet, but with a potentially better response, given that it binds to four out of five somatostatin receptors.Materials and methods: We present the case of an acromegalic patient with resistance to many therapies and response to trea...

ea0037ep893 | Thyroid cancer | ECE2015

Thyroid cancer arises in 5% of patients referred from primary care to a high-resolution thyroid clinic

Doblas Isabel Mancha , Cortes-Salazar Carmen Maria , Fernandez-Garcia Jose Carlos , Tinahones Francisco

Objective: To evaluate the prevalence of thyroid cancer in patients with suspected thyroid nodule referred from primary care.Methods: Retrospective cohort study which included patients with suspected thyroid nodule referred from primary care to a high-resolution thyroid nodule clinic. Demographic and clinical characteristics were collected, all patients underwent thyroid ultrasound and subsequently, a fine-needle aspiration (FNA) was performed if thyroid...