Endocrine Abstracts

Introduction: Osmotic demyelination syndrome (ODS) or commonly known as central pontine myelinolysis is commonly associated with rapid correction of hyponatraemia resulting in neurological deficits that manifests within days. The population commonly affected include alcohol dependence patients, the malnourished and liver failure patients. We describe a case of ODS developing in an alcoholic patient with symptoms developing 4 weeks after correcting hyponatraemia.<p class="a...

Graves’ disease is the most common cause of hyperthyroidism. It is well established that hyperthyroidism promotes a hypermetabolic state characterized by increased resting energy expenditure, increased lipolysis and gluconeogenesis. We describe a rare complication of thyrotoxicosis in a patient with type II diabetes on insulin, with no previous thyroid history. An 83 year old woman with type 2 diabetes on biphasic insulin presented with symptoms of polyuria, polydipsia a...

Patients with small bowel NET may present in a different way from other GPNET patients, with well-established disease and metastases. They may have long term symptoms that are well investigated but remain undiagnosed sometimes for years. To examine this supposition the presenting symptoms and outcomes of the first thirty patients with small bowel NET seen in 2018 were examined. Of these thirty patients eight were female and twenty-two were male with a median age of 64.5 years ...

Case: A 34-years-old male, construction worker, referred by GP with the history of vomiting, fatigue and near-collapse. Apart from alcohol excess, his past medical history was unremarkable. He did not have any personal or family history of any endocrinopathy, and was not taking any medication. Initial blood result were as below. ECG showed short QTc interval of 354 ms. His presentation was initially thought to be vomiting due to alcohol excess leading to dehydration and hyperc...

Introduction: Bile acid malabsorption (BAM) may be a contributing factor causing diarrhoea in patients with NETs, particularly among those who have undergone previous surgical resection of the terminal ileum and/or right colon or cholecystectomy (Naraev et al 2019). Aim(s): To identify the prevalence of bile acid malabsorption in neuroendocrine tumour patients (NET) at the Queen Elizabeth Hospital Birmingham (QEHB). Materi...

Background: We present a case of a 33 year old female with a background of Turner’s syndrome, adequately managed with growth hormone and oestrogen supplementation, Crohn’s disease, horse shoe kidney and subclinical hypothyroidismCase details: She presented to the emergency team with high-grade fever and right sided hemiplegia 10 days following Astra Zeneca COVID vaccination. Initial blood tests showed mildly raised CRP of 49, thrombocytopenia w...

Incidental adrenal masses is a common finding on abdominal imaging completed for other reasons. Majority of these masses are benign non-functioning adenomas. Investigations are required to ensure they are benign and do not have autonomous hormonal secretion.Aim: We completed an audit to review current practice in the assessment of adrenal incidentaloma at our organisation, a mid-size acute DGH, and compared it with European Society of Endocrinology (ESE)...

Prolactinomas are the most common functional pituitary tumours. Therapy is with dopamine agonists (DA). Cabergoline is frequently used as a first line agent; resistance to therapy is seen to other DA. We present a case of a 32 year old woman who moved to our area in the 1st trimester of pregnancy. She was known to have macroprolactinoma (maximal diameter > 1 cm), impinging on the optic chiasm. She was on cabergoline 0.5 mg once daily, but this was discontinued with no complica...

Over the last few years, there has been an increase in the demand on the National Health Service, with patients presenting to hospital with multiple co-morbidities and increasingly complex needs. The type of endocrine referrals received can vary both in complexity and also between clinicians. The Royal College of physician has published a ‘Referring wisely’ report in June 2017 which aims to improve and streamline the quality of referrals received in each speciality. ...

Introduction: Autosomal dominant hypocalcaemia (ADH) is caused by activating mutations of the calcium sensing receptor (CaSR). Symptomatology ranges from asymptomatic hypocalcaemia to paraesthesia, tetani, laringospasm and, seizures. This is the first report of congenital hyperinsulinism (CHI) in a child with ADH.Case report: A female infant, born at term from non-consanguineous parents, presented on D2 with persistent asymptomatic hypoglycaemia requirin...