Searchable abstracts of presentations at key conferences in endocrinology

ea0029p924 | Female Reproduction | ICEECE2012

Propranolol prevents stress induced polycystic ovary syndrome

Silva Barros P. , Kalil B. , Anselmo-Franci J.

We have shown that repeated cold stress increases ovarian sympathetic tonus and induces typical polycystic ovary syndrome (PCOS) features. Lesion of the noradrenergic nucleus Locus Coeruleus decreases ovarian noradrenaline release and prevents stress-induced PCOS in rats exposed to chronic intermittent cold stress. The aim of this study was to assess whether the alterations on ovarian morphology, ovulation rate and hormonal secretion induced by cold stress could be prevented b...

ea0029p1333 | Pituitary Basic | ICEECE2012

T3 and T4 rapidly regulate the TSH, FSH and LH α subunit gene expression at posttranscriptional level

Souza P. , Romano R. , Silva F. , Brunetto E. , Nunes M.

Several studies demonstrated that the thyroid hormones (TH) downregulate the transcriptional rate of beta and alpha TSH subunits. Recent data showed that T3 also acts posttranscriptionally reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized (Tx) rats. This study aimed to investigate whether similar effects occur for the alpha subunit synthesis after acute administration of T3 or T4</...

ea0020p2 | Adrenal | ECE2009

Von-Hippel Lindau disease and pheochromocytoma – case report

Daniel Silva Vaz J , Queiroz E , Lima Jorge Dores

Aims: VHL disease is an autossomal dominant syndrome that affects one in every 36 000 live births. The diagnosis is based on clinical criteria and the detection of the mutation on VHL gene. Most cases are diagnosed during the 2nd decade of life; this syndrome includes pheochromocytomas with the following characteristics: extraadrenal location, bilaterality, multifocal lesions, age of onset <30 years and discrete manifestations of catecholamine overproduction.<p class="...

ea0019p379 | Thyroid | SFEBES2009

Evaluation of thyroid ultrasound requests and fine needle aspiration in Northwest London Trust Hospital

Ratnasabapathy R , Bakshi J , De Silva A , Baburaj R

Background: Thyroid cancer commonly presents as a new palpable thyroid nodule or increase in size of a pre-existing nodule. A multidisciplinary thyroid lump clinic was established in September 2008 enabling patients to have one-stop clinical, biochemical, radiological and cytological assessment for evaluation of thyroid nodules. This audit predates this period, aiming to provide background information for future audit.Aim: To evaluate the requests for th...

ea0016p96 | Bone and calcium | ECE2008

Effects on bone turnover and bone mineral density of levothyroxine suppressive therapy in patients with benign nodular goiter

Duarte Leone , Silva-Nunes Jose , Lopes Ana-Filipa , Malheiro Fernando

Introduction: Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is still a matter of debate.Objective: The aim of the present study was to assess the effects of levothyroxine treatment on bone mineral density (BMD) and biochemical bone turnover markers.Methods: We determined thyroid function – TSH and free T4 (FT4), r...

ea0011p69 | Clinical case reports | ECE2006

Primary hyperparathyroidism (PHPT): Still a cause of hypertension resistant to therapy

Baptista AP , Morgado EC , Silva AP , Neves PL

High blood pressure is a common problem among patients in a Nephrology ward and outpatient clinic. However in those patients resistant to therapy, we must exclude a secondary cause. The authors present a case of a patient that was referred to our hospital due to complaints of headache, high blood pressure resistant to therapy (BP=240/130 mmHg), and images in renal ecography, which were compatible with enlarge left adrenal gland and left kidney atrophy. At admission the blood r...

ea0007p49 | Diabetes, metabolism and cardiovascular | BES2004

Increased C-jun N terminal kinase (JNK) activity may link insulin resistance and inflammation in human central obesity

Fowler A , Silva N , Burman C , Harte A , McTernan P , Kumar S

Central obesity is strongly associated with insulin resistance and chronic sub-clinical inflammation, which is implicated in the development of type 2 diabetes (T2DM). However, the mechanisms underlying this link remain unclear. Recently JNK, a mitogen activated protein kinase (MAPK), has been implicated in obesity and insulin resistance by interfering with insulin action. Studies in rodent models show that phosphorylated JNK-1 is elevated in obesity, whilst the absence of JNK...

ea0003p298 | Thyroid | BES2002

Profile of the thyroid function in a population with type-2 diabetes mellitus

Nobre E , Jorge Z , Pratas S , Silva C , Castro J

Subclinical thyroid dysfunction associated with a poor lipid profile and cardiac dysfunction. Patients with DM2 suffer from a greater risk of vascular disease, often in association dislipidemia. Thyroid dysfunction might either contribute to these factors or make them worse.Objective: To assess the prevalence of thyroid dysfunction among patients with diabetes and the relationship between that condition the control of diabetes and lipid profile.<p ...

ea0093oc23 | Oral communication 4: Pituitary and Neuroendocrinology | EYES2023

Different molecular forms of pituitary adenomas, explaining behavior and prognosis. A new concept

Corlan Ana-Silva , Cimpean Anca Maria , Raica Marius

Background: Pituitary adenomas(PAs) comprise 10%–25% of all intracranial tumors, the majority of them being benign. But 35% of all PAs are considered invasive, having a higher recurrence rate than benign ones.Objectives: We analyzed the expression of different angiogenic growth factors and their receptors in PAs and identified correlations with the hormone profile that could explain their behavior and prognosis.Methods: Our st...

ea0094p54 | Metabolism, Obesity and Diabetes | SFEBES2023

Unveiling the metabolic benefits of GLP-1 analogues in alström syndrome: implications for monogenic syndromic obesity management

Ali Sadaf , Paisey Richard , da Silva Xavier Gabriela , Hiwot Tarekegn

Background: Glucagon-like-peptide-1 (GLP-1) has been shown to improve body weight and glycaemic control in patients with common obesity and type 2 diabetes. Whether it confers the same metabolic benefits in monogenic syndromic obesity is unknown. This observational study aimed to examine the real-world efficacy of GLP-1 analogues in Alström syndrome (ALMS), a form of monogenic obesity.Method: We screened all 72 UK a...