Endocrine Abstracts

Background: Cross-sex hormone treatments are used to masculinize or feminize the bodies of female-to-male (FtM) or male-to-female (MtF) transsexuals, respectively. Redistribution of fat mass is expected to occur during the first 1–6 months in transgender males and in the first 3–12 months in transgender females.Objective: To examine the effects of cross-gender sex hormone therapy (CHT) on body composition in transsexual men and women.<p cla...

Background: Male-to-female transsexual persons use estrogens + antiandrogens to adapt their physical bodies to the female sex.Estrogens are powerful stimulators of synthesis and release of prolactin and serum prolactin levels are usually somewhat increased following estrogen treatment.Objective: To determine prolactin levels and to assess the risk of development of prolactinoma in male-to-female transgender subjects following cross-sex hormone therapy (C...

Introduction: Pheochromocytomas/paragangliomas are rare neuroendocrine tumors. Although mostly sporadic, about 1/3 of the cases correspond to inherited autosomal dominant syndromes, often associated with germline mutations of the SDHD, SDHC and SDHB genes. The association with the SDHAF2(SDH5) gene has been recently discovered, with only few cases published worldwide, and it presents as a paraganglioma of the head and neck, without previous known description of other locations...

Aims: We aimed to evaluate the relationship between glycosylated hemoglobin (HbA1c), time-in-range (TIR), Glucose Management Index (GMI) and coefficient of variation (CV) in a cohort of adult patients with type 1 diabetes (T1DM) and flash glucose monitoring (FGM).Material and methods: Cross-sectional study of patients with T1DM who FGM from Córdoba, Spain. Demographic and analytical data were collected. Glucose metrics and engagement statistics (adj...

Metabolic syndrome (MS) is a group of signs that increase the risk of developing cardiovascular diseases and type 2 diabetes mellitus (DM2). MS includes at least 3 of these signs: central obesity, dyslipidemia, hypertension, fasting glucose disorders, and insulin resistance. The consumption of sugar drinks, a high-calorie diet, a sedentary lifestyle, and environmental pollutants such as arsenic increase the risk of developing MS. Arsenic affects beta-cell function and insulin ...

Introduction: Differentiated thyroid cancer (DTC) is rare in the paediatric population when compared to adults. Paediatric patients often present with advanced disease at diagnosis, characterized by multifocal disease, heightened lymph node involvement, and distant metastasis. Additionally, they face a higher risk of post-operative complications in comparison to adults. Despite that, paediatric DTC exhibits an excellent prognosis.Methods: A retrospective...

Introduction: Adrenocortical carcinoma is a rare type of cancer that usually has a dismal prognosis. The concurrent hormonal excess of some of these tumours can have an additional negative impact on patients´ morbidity and mortality.Clinical Case: We present the case of a 57-year-old woman diagnosed with stage IV adrenocortical carcinoma, with liver and bone metastasis, and associated ACTH-independent Cushing syndrome and hyperandrogenism. The patie...

Introduction: Pancreatic neuroendocrine tumors (PNETs) originate from neuroendocrine islet cells and can therefore secrete several neuropeptides. Multiple and secondary hormone secretion have been described in a minority of cases, mostly with advanced disease, and it has been hypothesized that this complex secretion pattern can serve as a marker for tumor behavior.Case report: Male patient, 69 years old, diagnosed with a glucagonoma with pulmonary and he...

Introduction: Diabetes mellitus secondary to exocrine pancreas diseases (pancreatogenic DM) has an unknown incidence and is considered underdiagnosed. Our objective was to evaluate the glycemic control parameters in patients with pancreatogenic DM who started Flash glucose monitoring (FGM).Methods: Prospective, observational study in a Spanish hospital. Patients with pancreatogenic DM who started FGM from January 2021 to August 2022 were recruited. Patie...

Introduction: The most common pituitary adenoma is a prolactinoma.The most relevant clinical manifestations are amenorrhoea galactorrhoea infertility gonadal and sexual dysfunction. Macroprolactinoma are more often in men because they had more difficulty for asking the sintomatology. Initial treatment of macroadenoma wasinitiated with a dopamine agonist with control of PRL concentration and size of tumorClinical case: A 52-year-old manpresented ...