Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp90 | Diabetes & complications 2 | ECE2017

The G allele of the BDKRB1 rs12050217 polymorphism is associated with protection for diabetic retinopathy

Brondani Leticia A. , Pisco Julia , Guimaraes Jorge A. , Crispim Daisy , Berger Markus

Background: Diabetic retinopathy (DR) is a chronic diabetic complication occurring in most diabetic patients after 20 years of disease. Progression of DR to its sight threatening stages is usually associated with worsening of underlying retinal vascular dysfunction and disease. The plasma kallikrein kinin system is activated during vascular injury, mediating important functions in inflammation, blood flow, and coagulation. Bradykinin B1 receptor (B1R) is expressed in human ret...

ea0049ep257 | Calcium & Vitamin D metabolism | ECE2017

Normocalcemic versus Hypercalcemic Primary Hyperparathyroidism: a comparative study

Mokrysheva Natalya , Mirnaya Svetlana , Eremkina Anna , Krupinova Julia , Kovaleva Elena

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is defined as a condition in which persistently normal serum calcium levels are observed in the presence of high levels of parathyroid hormone (PTH). NPHPT is a new entity which possibly represents a clinically symptomatic disease and which has generated a considerable scientific interest.Aim: To compare the clinical and laboratory data between the normocalcemic and hypercalcemic forms of PH...

ea0049ep318 | Clinical case reports - Thyroid/Others | ECE2017

Clinical case of atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures

Eremkina Anna , Mokrysheva Natalia , Krupinova Julia , Mirnaya Svetlana , Voronkova Iya

Introduction: Atypical parathyroid adenoma (APA) is rarely encountered cause of primary hyperparathyroidism (PHPT). No definite criteria are considered to distinguish preoperatively APA from parathyroid typical adenoma or carcinoma.The aimTo describe the clinical course of a patient with an atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures.Case presentation: A 61-year-old...

ea0049ep347 | Endocrine tumours and neoplasia | ECE2017

Recurrent ectopic parathyroid carcinoma

Krupinova Julia , Mokrysheva Natalia , Eremkina Anna , Pigarova Ekaterina , Mirnaya Svetlana

Background: In most cases of parathyroid carcinoma (PC) only recurrence could be a credible feature of malignancy.Clinical case: At the age of 19 years a woman was diagnosed with urolithiasis. At the age of 22 years she had a surgical resection of the neck nodule at the right site in the projection of carotid triangle. After the histological study, ectopic parathyroid tumor was misdiagnosis with paraganglioma (material is available for review). At the ag...

ea0048cp21 | Poster Presentations | SFEEU2017

A challenging case of hypercalcaemia due to primary hyperparathyroidism in an elderly patient successfully treated with non-elective surgical inpatient management

Hope David CD , Ostberg Julia E , Polazzo Fausto

An 86-year old man was admitted to hospital with gradual decline in mobility and leg weakness. Co-morbidities included atrial fibrillation, hypertension and osteoarthritis. The adjusted serum calcium on admission was 3.42 mmol/l; bone profile showed phosphate 0.56 mmol/l, alkaline phosphatase 140 U/l, albumin 34 g/l, parathyroid hormone 21.4 pmol/l. He was vitamin-D replete (68 nmol/l) with normal renal function. The hypercalcaemia was not thought to be due to any medications....

ea0039oc6.3 | Oral Communications 6 | BSPED2015

Skeletal changes in pre-pubertal children with loss of function mutations in the melanocortin-4 receptor

Dimitri Paul , Collet Tinh-Hai , Keogh Julia , Farooqi Sadaf

Background: Obese children are at greater risk of fracture. However, previous evidence suggests that obese children with a mutation in the melanocortin-4 receptor (MC4R) have a high age-adjusted bone mass. MC4R deficiency is associated with increased linear growth, so bone mass may be over-estimated due to patients being taller. We therefore aimed to compare body size-adjusted bone mass of lean and obese pre-pubertal children with those who have a mutation in MC4R.<p class...

ea0039ep25 | Diabetes | BSPED2015

Using co-production and graphic facilitation to improve patient experience in type 1 diabetes mellitus

Blackstock Sarah , Hopkins Julia , Ria Matteo , Kumar Priya

Introduction: Co-production refers to working in partnership with service-users to improve provision of services. Increasing evidence highlights that co-production can improve health care and result in financial savings. Service-users are involved in defining the problem or need, creating the solution, delivering it, and evaluating it. This approach demands longer-term engagement by service-providers but leads to sustainable change. Graphic facilitation is the use of large-sca...

ea0038p3 | Bone | SFEBES2015

Reduction in daily hydrocortisone dose in adrenal insufficiency improves significantly bone mineral density – results from a 2-years prospective trial

Schulz Julia , Koetz Kathrin , Ventz Manfred , Diederich Sven , Quinkler Marcus

Introduction: Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive life-long glucocorticoid (GC) replacement therapy. Today daily GC doses are still higher than the reported adrenal cortisol production rate, and are not able to reproduce the physiological secretion pattern. This might result in long-term morbidities such as osteoporosis. Until now no prospective trial was performed investigating the long-term effect o...

ea0038p108 | Clinical practice/governance and case reports | SFEBES2015

Separate, sequential, endocrine, and glycaemic effects of ipilimumab and pembrolizumab in metastatic melanoma

Anstey Julia , Solomon Andrew , Nathan Paul , Shaw Heather

Ipilimumab, pembrolizumab, and nivolumab – novel immune checkpoint blockade drugs – are increasingly used in the treatment of metastatic melanoma and other cancers. Ipilimumab is an anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) MAB and the first drug shown to improve overall survival in metastatic melanoma. Hypophysitis is a widely described side-effect linked with both lymphocytic inflammation and a direct toxic effect on the pituitary in mouse studies, but has been...

ea0038p242 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Characterisation of the astrocytic response to acute and recurrent hypoglycaemia

Walker Julia Vlachaki , Ashford Mike , McCrimmon Rory , Beall Craig

Background: In diabetes, exposure to frequent episodes of hypoglycaemia diminishes a persons awareness of hypoglycaemia, by poorly defined mechanisms. Evidence suggests that, at least in part, changes in cell behaviour within the ventromedial hypothalamus may contribute to this defect and that changes in AMP-activated protein kinase (AMPK), a key glucose-sensing enzyme are involved. Evidence suggests there are (mal)adaptations within neurons, however, little is known about cha...