Searchable abstracts of presentations at key conferences in endocrinology

ea0095p155 | Thyroid 2 | BSPED2023

Thyroid hormones and the kidneys: Don’t forget to check renal function in thyroid disease

Aslam Aisha A , Martin Lee , Prasad Rathi , Paraskevopoulou Niki , Water Aoife M , Chan Li F

Background: Thyroid hormones are essential for the adequate growth and development of the kidney and also target changes in glomerular and tubular functions and electrolyte and water homeostasis. Hyperthyroidism leads to an increase in glomerular filtration rate (GFR) and renal blood flow with converse effects seen in hypothyroidism. In turn, the kidneys are responsible for the metabolism and elimination of thyroid hormones and thus renal disease can lead to s...

ea0098c24 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

68Ga-DOTATATE/18F-FDG dual PET: Utility of the NETPET score in management of G2-3 WD NENs

Nunez Jose E. , Chan David L. , Kulanthaivelu Roshini , Murad Vanessa , Singh Simron , Metser Ur

Background: The clinical heterogeneity of G2 and G3 well-differentiated GEP-NENs make it difficult to choose an effective treatment plan, highlighting the need of molecular imaging in the treatment of NETs patients. It has been suggested that a dual-tracer 68Ga-DOTATATE/18F-FDG grading scoring system could be a useful imaging biomarker. This pilot study aims to validate the prior observation from Chan et al. (BJC 2022) of variability in NETPET scores in G2-G3 WD GEP NENs and a...

ea0099rc9.2 | Rapid Communications 9: Pituitary and Neuroendocrinology | Part II | ECE2024

Elevated prolactin: Do not over investigate, cannulate!

Hawkins Anna , Enriquez Nancy , Tanday Raj , Shah Usman , Chan Carmela , Casey Edel , Nikookam Khash

Aim: Role of Endocrine Specialist Nurse (ESN) in performing cannulated prolactin and subsequent impact on outpatient clinic activities.Introduction: Hyperprolactinemia is a common condition in endocrine clinical practice. It may occur in any sex, at any age and its prevalence and incidence depend on study population. The most common physiological causes of elevated prolactin are stress, lactation, pregnancy and exercise. Non-physiological causes include ...

ea0099ep904 | Thyroid | ECE2024

Acute perforated viscus complicating thyroxicosis: a case series

lin Chan Pei , Wei Lim Qing , Hang Lim Wei , Fikri Bin Azalan Adib , Mun Cheah Jean

Introduction: In cases of emergent surgical conditions, pre-medication of patients with thyrotoxicosis is required to reduce the patient’s risk of thyroid storm in the perioperative and postoperative state. Perforated viscus with concurrent thyrotoxicosis is rarely reported. We report 2 cases of thyrotoxicosis and acute abdomen with perforated viscus.Case 1: A 27-year-old gentleman with underlying hyperthyroidism, presented with central epigastric p...

ea0103oc5.1 | Endocrine Oral Communications 1 | BSPED2024

BRINP2 gene variants are implicated in severe delayed puberty associated with neurodevelopmental phenotypes

Al-Sayed Yasmin , Momeni Saleh , He Wen , Chan Yee-Ming , Howard Sasha

The genetic aetiology of central delayed puberty is closely related to the development and function of the gonadotropin-releasing hormone (GnRH) endocrine network. GnRH is the master hormone regulating the reproductive axis and its pulsatile secretion from neurons of the mediobasal hypothalamus is crucial for puberty onset and fertility. Loss-of-function in genes in GnRH neuron pathways can lead to a phenotypic spectrum from self-limited delayed puberty (SLDP) to partial or co...

ea0078OC9.3 | Oral Communications 9 | BSPED2021

Investigating paediatric weight management apps

Ayamad Sithara , Mohebi Mustafa , Sarathchandra Nichola Rowena , Shah Pratik , Desai Ashish , Gevers Evelien , Peh Gin , Ford-Adams Martha , Chan Li

Background: Childhood obesity is the single most pressing public health emergency of the 21st century. The prevalence has increased at alarming rates and globally over 41 million children under 5 years of age are classified as overweight/obese. Overweight and obese children are likely to stay obese as adults and develop multi-morbidities including type 2 diabetes, cancer, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease at an earlier age. The ava...

ea0086p243 | Neuroendocrinology and Pituitary | SFEBES2022

Imaging surveillance of completely resected gastroenteropancreatic neuroendocrine tumors is associated with high levels of radiation exposure

Ianuzzi Jordan , Yeo Caitlin , Parkins Vicky , Pasieka Janice , Ruether Dean , Chan Denise , Albalawi Zaina , Stewart Errol , Lithgow Kirstie

Background & Aims: Neuroendocrine tumours (NET) are a heterogenous group of neoplasms that secrete peptides and neuroamines. For potentially malignant gastroenteropancreatic (GEP) NET, surgical resection represents the only curative option. Ten-year imaging surveillance programs using cross sectional imaging are recommended due to long time-to-recurrence following resection. We performed a retrospective chart review to evaluate radiation exposure associated with surveillan...

ea0089c30 | Clinical – Surgery/Applied Pathology | NANETS2022

Liver-Directed Therapy of Neuroendocrine Liver Metastases

Meloche-Dumas Leamarie , Mercier Frederic , Barabash Victoria , Law Calvin , Coburn Natalie , Singh Simron , Myrehaug Sten , Chan Wing , Hallet Julie

Background: The optimal therapy sequencing for metastatic neuroendocrine tumors (NETs) remains undefined. Recent advances in systemic therapies may have changed approaches. Better understanding in patterns of care is necessary to assess and design treatment strategies. We examined the use of factors associated with liver-directed therapy over time.Methods: We conducted a population-based study of metastatic NETs over 2000-2019. Outcomes were use of liver...

ea0090p274 | Adrenal and Cardiovascular Endocrinology | ECE2023

Response to Crinecerfont Treatment in Adults with Classic Congenital Adrenal Hyperplasia Is Correlated with Elevated Baseline Hormone Levels But Not Glucocorticoid Dose

Auchus Richard , Sarafoglou Kyriakie , Y. Fechner Patricia , Vogiatzi Maria , Giri Nagdeep , Roberts Eiry , Sturgeon Julia , Chan Jean L. , Farber Robert

Introduction: Corticotropin-releasing factor type 1 (CRF1) receptor antagonists, such as crinecerfont, have recently been investigated for the treatment of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD), a rare autosomal disease characterized by cortisol deficiency, elevated adrenocorticotropic hormone (ACTH), and excess androgen production. In a study of adults with 21OHD, treatment with crinecerfont for 14 days led to median ...

ea0059p083 | Clinical practice, governance & case reports | SFEBES2018

Evaluation of quality of care provided to patients with Turner syndrome (TS) cared for by the University Hospitals of Leicester NHS Trust

Chan Yin Chun Alex , Kuo Pei-juo , Mahmod Sameer , Levy Miles J , Reddy Narendra L , Yusuff Shafiq , Bhake Ragini C

Background: TS, resulting from partial or complete loss of an X-chromosome, is a rare diagnosis1. In addition to its well-described phenotypic features2, a number of multi-systemic conditions may develop over the lifespan of a Turner female that require long-term surveillance which is challenging to deliver in today’s ‘specialised’ services NHS.Aim: To evaluate UHL service provision against the only guidelines for the...