Endocrine Abstracts

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

Background: Papillary thyroid carcinoma (PTC), especially its classic papillary, oncocytic, Warthin-like, tall and columnar cell variants, is characterized by a high frequency of BRAFV600E mutation that varies in different studies from 36 to 85%. Prognostic significance of the mutation remains controversial.Objective: Aim of the study was an analysis of relationship between clinical, morphological and prognostic characteristics of PTC with BRAFV600E asse...