Searchable abstracts of presentations at key conferences in endocrinology

ea0034p268 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

H6PDH deficiency in muscle impacts amino acid metabolism

Zielinska Agnieszka , Doig Craig , Stewart Paul , Adamski Jerzy , Lavery Gareth

Hexose-6-phosphate dehydrogenase is an important factor in setting the redox status of the endo-/sarcoplasmic reticulum (ER/SR) lumen by generating the NADPH:NADP+ ratio for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mediated glucocorticoid (GC) activation. H6PDH knockout mice (H6KO) clearly demonstrate the obligate nature of 11β-HSD1 for H6PDH, and display a vacuolating of type IIb fiber myopathy, elevated glycogen storage and type II to type...

ea0041gp29 | Adrenal (2) | ECE2016

Plasma metabolomics profile in patients with Cushing’s syndrome

Dalmazi Guido Di , Quinkler Marcus , Deutschbein Timo , Prehn Cornelia , Rayes Nada , Kroiss Matthias , Fassnacht Martin , Berr Christina , Stalla Gunter , Adamski Jerzy , Reincke Martin , Beuschlein Felix

Background: Cushing’s syndrome (CS) is a chronic disorder characterized by endogenous cortisol excess resulting in long-term metabolic and cardiovascular consequences. The identification of metabolic alterations related to hypercortisolism could be beneficial in tailoring treatments of co-morbidities. Our aim was to characterize the metabolic alterations of patients with hypercortisolism by targeted plasma metabolomic profiling.Methods: Subjects (<e...

ea0037gp.05.04 | Developmental and paediatric endocrinology | ECE2015

Pilot study on the effects of cross-sex hormone treatment in transsexual persons on metabolism by means of metabolomics profiling

Auer Matthias K , Xu Tao , Roepke Yasmin , Stalla Gunter K , Stieg Mareike , Van Caenegem Eva , Prehn Cornelia , Wang-Sattler Rui , Adamski Jerzy , T'sjoen Guy

Introduction: Sex steroid hormones exert a wide range of effects on metabolism. New techniques such as metabolomic profiling allow for a deeper insight into metabolic regulation. In epidemiological samples it has been demonstrated that most of these metabolites show sex-specific differences. However, if these differences are attributable to the effects of sex hormones or genetics is little understood so far.Methods: We performed targeted metabolomics pro...

ea0056p1040 | Thyroid (non-cancer) | ECE2018

A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans

Pietzner Maik , Homuth Georg , Kohrle Josef , Budde Kathrin , Kastenmuller Gabi , Brabant Georg , Volzke Henry , Artati Anna , Adamski Jerzy , Volker Uwe , Nauck Matthias , Friedrich Nele

Background: Numerous animal models have shown impressive beneficial metabolic effects of the putative thyroid hormone (TH)-derivative 3,5-diiodothyronine (3,5-T2), including the prevention of insulin resistance or the reversal of hepatic steatosis, in the absence of thyrotoxic side effects. In contrast, the endogenous fate of 3,5-T2 in humans is still unclear. Comprehensive molecular profiling holds promise to gain deeper insights in metabolic alterations associated with serum...