Searchable abstracts of presentations at key conferences in endocrinology

ea0013p332 | Thyroid | SFEBES2007

Propylthiouracil induced foetal goitre: a food for thought

Patani Olomuza , Heald Adrian

Propylthiouracil (PTU) treatment for thyrotoxicosis in pregnancy is common clinical practice. However maternal ingestion of PTU has been recognised to be associated with the development of foetal hypothyroidism and in rare cases at high doses of PTU, overt foetal goitre. Foetal goitre can be potentially dangerous due to mechanical obstruction and needs to be carefully monitored in utero. We report a case of development of goitre in utero secondary to maternal ingestion of PTU ...

ea0077p118 | Thyroid | SFEBES2021

Cost-effectiveness analysis of liothyronine for the management of treatment unresponsive hypothyroidism based on latest evidence

Heald Adrian , Skiadas Konstantinos , Fitzsimmons Deborah , Anderson Pippa , Hughes Dyfrig

Introduction: Between 5-10% of patients with hypothyroidism treated with levothyroxine (T4) continue to experience profound symptoms, despite achieving free T4/thyroid stimulating hormone concentrations within reference range. Liothyronine is sometimes added to levothyroxine, but its use is controversial due to uncertainties in clinical/cost effectiveness.Methods: An economic model was developed to estimate the incremental cost per quality-adjusted life ...

ea0015p364 | Thyroid | SFEBES2008

Hypothyroidism and hyponatraemia: diagnostic relevance of ADH measurement

Khan Azhar , Nair Sunil , Waldron Julian , Davies Marten , Heald Adrian

Background: Hyponatraemia is one of most common electrolyte abnormalities in acutely ill elderly patients. Severe hypothyroidism is often associated with hyponatraemia. The mechanism of hyponatraemia in hypothyroidism is not fully understood. It is suggested that hypothyroidism induces hyponatraemia either by inappropriate release of ADH or by decrease in GFR. Regardless of the mechanism, the net effect is impairment of water excretion. We report a case of severe hypothyroidis...

ea0077p39 | Metabolism, Obesity and Diabetes | SFEBES2021

Longitudinal clinical trajectory analysis of individuals before and after diagnosis of Type 2 Diabetes Mellitus (T2DM) indicates that vascular problems and asthma pre-date diabetes diagnosis by many years

Heald Adrian , Fachim Helene , Stedman Mike , Gibson Martin , Anderson Simon G , Peng Yonghong , Ollier WiIliam

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

ea0077p104 | Reproductive Endocrinology | SFEBES2021

An exploration of the association between CAG repeat status and mortality in men

Heald Adrian , Cook Michael , Javed Ahmed , Fachim Helene , O’Neill Terence , Wu Fred

Introduction: The androgen receptor (AR) mediates the peripheral effects of testosterone. The main mechanism of action for the AR is direct regulation of gene transcription. Available evidence suggests that the number of CAG repeats in exon-1 of the AR gene is negatively correlated with transcriptional activity of the AR and that CAG repeat number links to mortality rate in T2DM men. The aim of this analysis was to determine the association between CAG repeat number and all ca...

ea0065p191 | Metabolism and Obesity | SFEBES2019

Male testosterone levels and laboratory practice: a need for a standardised approach to measurement and reporting

Livingston Mark , Downie Paul , Hackett Geoffrey , Marrington Rachel , Heald Adrian , Ramachandran Sudarshan

Background: Diagnosis and treatment guidelines of men with adult-onset testosterone deficiency (TD) were published by the British Society for Sexual Medicine (2017). Laboratory practice has a major role in supporting these with accurate and precise total testosterone (TT) methods and standardised pre- and post-analytical protocols.Objective: Our study investigated whether laboratory practice supported management guidelines of adult-onset TD.<p class=...

ea0065p279 | Neuroendocrinology | SFEBES2019

CACNA1C genotype does influence CACNA1C methylation and the association with cortisol release/potential mental health resilience

Pennington Kyla , Klaus Kristel , Fachim Helene , Trischel Ksenia , Dalton Caroline , Reynolds Gavin , Heald Adrian

Introduction: CACNA1C gene encodes the L-type voltage dependent calcium channels and its variants are associated with susceptibility to psychiatric disorders. We recently provided evidence of a genotype-by-environment interaction of the CACNA1C rs1006737 polymorphism, suggesting that the cortisol awakening response (CAR), an indicator of HPA-axis function, might be increased in non-risk allele carriers (GG) who have experienced childhood trauma (CT). In these...

ea0065p374 | Reproductive Endocrinology and Biology | SFEBES2019

Diagnostic evaluation of polycystic ovarian syndrome: how the biochemistry stacks up against subsequent ultrasound scan evaluation

Karia Amar , Duff Christopher , Heald Adrian , Britton Ingrid , Fryer Anthony , Wu Pensee

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. PCOS is associated with future type 2 diabetes/cardiovascular disease. Accurate diagnosis is important for early preventative interventions. However, it can take >2 years and contact with 3 or more health professionals before PCOS is diagnosed. We aimed to determine patterns of biochemical investigations performed for PCOS following initial consultation and assess their ...

ea0031p137 | Cytokines and growth factors | SFEBES2013

Genes for IGF2 and related IGF binding proteins are associated with longitudinal trends in BMI

Narayanan Ram Prakash , Fu Bo , Payton Antony , Donn Rachelle , Heald Adrian , Ollier William ER , Gibson Martin

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...

ea0015p6 | Bone | SFEBES2008

Sunlight deficiency: a reversible cause of low serum phosphate?

Chambers Thomas , Heald Adrian , Radford Daniela , Waldron Julian , Davies Marten , Baines Malcolm

Background: Vitamin D3 is generated in the skin of humans from 7-dehydrocholesterol by ultraviolet light. Vitamin D3 is hydroxylated to its metabolically active form in the liver and kidneys. The hydroxylated form of Vitamin D3, is required for both phosphate and calcium absorption in the gut and reabsorption from the kidneys. Vitamin D deficiency is associated with a low circulating calcium and phosphate.Case report: A 5...