Searchable abstracts of presentations at key conferences in endocrinology

ea0013p332 | Thyroid | SFEBES2007

Propylthiouracil induced foetal goitre: a food for thought

Patani Olomuza , Heald Adrian

Propylthiouracil (PTU) treatment for thyrotoxicosis in pregnancy is common clinical practice. However maternal ingestion of PTU has been recognised to be associated with the development of foetal hypothyroidism and in rare cases at high doses of PTU, overt foetal goitre. Foetal goitre can be potentially dangerous due to mechanical obstruction and needs to be carefully monitored in utero. We report a case of development of goitre in utero secondary to maternal ingestion of PTU ...

ea0099ep932 | Pituitary and Neuroendocrinology | ECE2024

Psychological aftermath of acromegaly: a case report

Warner-Levy John , Heald Adrian

Case: Acromegaly is associated with osteoarthritis due to soft tissue swelling. Our patient was first diagnosed with acromegaly in 2001 at the age of 51, subsequently undergoing a transsphenoidal pituitary adenoma resection in 2002, followed by postoperative radiotherapy in 2003, with subsequent development of anterior hypopituitarism. He has comorbidities of osteoarthritis, (having previously undergone bilateral total hip replacements and a left total knee replacement), bunio...

ea00100wb3.2 | Workshop B: Disorders of the hypothalamus and pituitary (II) | SFEEU2024

Psychological aftermath of acromegaly: a case report

Warner-Levy John , Heald Adrian

Acromegaly is associated with osteoarthritis due to soft tissue swelling. Our patient was first diagnosed with acromegaly in 2001 at the age of 51, subsequently undergoing a transsphenoidal pituitary adenoma resection in 2002, followed by postoperative radiotherapy in 2003, with subsequent development of anterior hypopituitarism. He has comorbidities of osteoarthritis, (having previously undergone bilateral total hip replacements and a left total knee replacement), bunionectom...

ea0094p88 | Neuroendocrinology and Pituitary | SFEBES2023

Macroprolactin: Do we need to repeat its measurement?

Livingston Mark , Laing Ian , Heald Adrian

Macroprolactinaemia, a common phenomenon variably expressed in different assays, influences interpretation of prolactin results, as recognised since 1978. The degree of macroprolactinaemia manifest over time is less well described. We examined how macroprolactin status (based on polyethylene glycol(PEG) precipitation prolactin % recovery) varied over serial measurements in hyperprolactinaemic individuals.Methods: All serum total prolacti...

ea0077p118 | Thyroid | SFEBES2021

Cost-effectiveness analysis of liothyronine for the management of treatment unresponsive hypothyroidism based on latest evidence

Heald Adrian , Skiadas Konstantinos , Fitzsimmons Deborah , Anderson Pippa , Hughes Dyfrig

Introduction: Between 5-10% of patients with hypothyroidism treated with levothyroxine (T4) continue to experience profound symptoms, despite achieving free T4/thyroid stimulating hormone concentrations within reference range. Liothyronine is sometimes added to levothyroxine, but its use is controversial due to uncertainties in clinical/cost effectiveness.Methods: An economic model was developed to estimate the incremental cost per quality-adjusted life ...

ea0015p364 | Thyroid | SFEBES2008

Hypothyroidism and hyponatraemia: diagnostic relevance of ADH measurement

Khan Azhar , Nair Sunil , Waldron Julian , Davies Marten , Heald Adrian

Background: Hyponatraemia is one of most common electrolyte abnormalities in acutely ill elderly patients. Severe hypothyroidism is often associated with hyponatraemia. The mechanism of hyponatraemia in hypothyroidism is not fully understood. It is suggested that hypothyroidism induces hyponatraemia either by inappropriate release of ADH or by decrease in GFR. Regardless of the mechanism, the net effect is impairment of water excretion. We report a case of severe hypothyroidis...

ea0094p78 | Metabolism, Obesity and Diabetes | SFEBES2023

Endocrine consequences of inherited metabolic disorders: Experience from a joint clinic

Bassett John , Puente Nuria , Heald Adrian , Stepien Karolina

Introduction: Substrate accumulation, energy deficiency or complex molecule defects characterize inherited metabolic disorders (IMDs), accounting for their multi-system manifestations. One important aspect of this is endocrinopathy, which is relatively common but underestimated in IMDs, presenting in childhood following diagnosis or sometimes a presenting symptom in adults where there is multi-system or multi-gland involvement. Endocrinopathies may be secondar...

ea0104p116 | Diabetes & Metabolism | SFEIES24

Semaglutide intervention in overweight people with schizophrenia: the road back to better physical health - preliminary results from a feasibility study

Heald Adrian , Warner Levy John , Firth Joseph , Syed Akheel

Introduction: Weight gain and its associated adverse health consequences have become a significant aspect of the life experience of many people with schizophrenia and other severe enduring mental illnesses (SMIs). Glucagon-like peptide -1(GLP-1) receptor agonists could be of substantial value in addressing this unmet need. We aimed to determine whether semaglutide treatment is feasible and acceptable to individuals in an inpatient setting and successful in facilitating weight ...

ea0104p189 | Reproductive Endocrinology | SFEIES24

Is there an association between daylight hours and serum testosterone levels in men?

Livingston Mark , Heald Adrian , Hackett Geoff , Ramachandran Harishnath , Ramachandran Sudarshan

Introduction: Studies assessing variability of serum testosterone levels associated with seasonal environmental factors have been contradictory. We assessed associations between the seasons and changes (δ) in seasonality indices and male serum total testosterone (δTT) variability.Methods: Data were collected in 144 men with paired serum TT samples (126 non-fasting/18 fasting) analysed at Walsall Manor Hospital, UK (52.3 degrees...

ea0077p39 | Metabolism, Obesity and Diabetes | SFEBES2021

Longitudinal clinical trajectory analysis of individuals before and after diagnosis of Type 2 Diabetes Mellitus (T2DM) indicates that vascular problems and asthma pre-date diabetes diagnosis by many years

Heald Adrian , Fachim Helene , Stedman Mike , Gibson Martin , Anderson Simon G , Peng Yonghong , Ollier WiIliam

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...