Endocrine Abstracts

Introduction: Levothyroxine is the first choice treatment for patients with hypothyroidism However, some people would continue to have symptoms of thyroid disease despite biochemical control on levothyroxine. Others might be intolerant to levothyroxine.Aim: The aim of this audit is to evaluate UHL endocrinology practice against local and national guidelines with regards to prescribing and monitoring of liothyronine treatment in 2019.<p class="abstext...

Introduction: Definitive treatment of hyperthyroidism with Radioactive Iodine (RAI) ablation therapy has been associated with weight gain from RAI induced hypothyroidism. Literature on weight data of post-RAI patients following normalisation of thyroid function is equivocal.Objective: We undertook a retrospective study to evaluate the effect of RAI on weight in Hyperthyroid patients in University Hospitals of Leicester NHS Trust (UHL). <p class="abst...

Despite that the standard treatment for hypothyroidism is Levothyroxine, it is now recognised that a certain group of patients would benefit from treatment with Liothyronine either alone or in combination with Levothyroxine. Compared to Levothyroxine, Liothyronine has shorter-half life and can be associated with less predictable biochemical outcomes. In 2021, we published the outcome of the 1 st cycle of audit of use of Liothyronine at the University Hospital of Lei...

Introduction: There are patients who remain symptomatic with hypothyroidism despite apparent adequate replacement on levothyroxine (LT4) therapy. We present an observation where monozygotic twins responded only to combination therapy with liothyroinine (LT3), and were found to have a genetic variation which may have clinical significance in thyroid metabolism.Case report: A 47-year-old female with polyglandular auto-immune syndrome (APS1) presented with ...

Thyroid cancer is the most common endocrine malignancy accounting for 1% of new cancer cases each year. Even after treatment, one in five patients develop recurrence eventually. Therefore, close follow up is crucial after treatment. Current tumour biomarkers are not perfect, and there is a need for a more sensitive and specific way of detecting early recurrence. Liquid biopsies have emerged as a novel marker in tumour surveillance and monitoring response to treatment. In parti...

Introduction: Phaeochromocytoma affects <1:100000 people per year. Wilms tumour (WT) affects almost 1:10000 children each year. Both tumours are associated with somatic genetic alterations: Phaeochromocytoma (RET, VHL, NF1, SDHA, SDHAF2, SDHB, SDHC, SDCD, TMEM127 and MAX); WT (WT1, 11p13, 11p15, tp53, NSD1, KDM3B, BRCA2). Both tumours affecting the same person have only been reported twice in the literature.Case Report: We report a lady who, at the a...

Introduction: 48,XYYY is a rare condition where two extra Y chromosomes alter the neurological, skeletal and reproductive development of the affected individual. Clinical features are usually subtle and the diagnosis is not suspected until fertility issues arise. Here, were report an adult patient with 48,XYYY in the Endocrinology Clinic.Case report: A 24-year-old male was referred to UHL Endocrinology Clinic following i...

Introduction: The BRAF V600E mutation has been reported in 27– 90% of Papillary Thyroid Carcinoma (PTC). BRAF V600E may be associated with adverse outcomes in PTC. It is unknown if detection of BRAF V600E can play a key role in prognosis, and can be used as a surrogate-marker of poor outcomes in PTC.Objectives: • To investigate prevalence of BRAF V600E mutation in TC using digital droplet PCR (ddPCR)....

Introduction: Hydatid cysts disease (HSD) is a parasitic disease caused by echinococcus granulosus. It is common in areas where the parasite is endemic; North Africa, the Middle East, Central and Far Asia, Central America and Australia. Liver (44-77%) and lungs (10-50%) are the preferred locations for HSD. Here we report a rare case of HSD affecting the adrenal gland.Case report: A 62-year-old female complained of right ...

Background: One of the main indications for parathyroidectomy surgery in primary hyperparathyroidism (PHPT) is osteoporosis. NICE guideline recommends 2-3 yearly Dual-energy X-ray absorptiometry (DEXA) assessments to evaluate bone mineral density (BMD) in asymptomatic PHPT. Objective: We undertook an audit to evaluate bone health practice in PHPT patients in line with NICE guidelines.Methodology: Retrospective case notes and electr...