Searchable abstracts of presentations at key conferences in endocrinology

ea0077p256 | Thyroid | SFEBES2021

Audit of Liothyronine Prescribing at the University Hospitals of Leicester (UHL) NHS Trust

Al Jumaah Ali , Levy Miles , Bhake Ragini , Reddy Narendra

Introduction: Levothyroxine is the first choice treatment for patients with hypothyroidism However, some people would continue to have symptoms of thyroid disease despite biochemical control on levothyroxine. Others might be intolerant to levothyroxine.Aim: The aim of this audit is to evaluate UHL endocrinology practice against local and national guidelines with regards to prescribing and monitoring of liothyronine treatment in 2019.<p class="abstext...

ea0090p227 | Thyroid | ECE2023

Radioactive Iodine Treatment in Hyperthyroidism is Associated with Increased Body Weight

Al Jumaah Ali , Gohil Shailesh , Levy Miles J , Reddy Narendra

Introduction: Definitive treatment of hyperthyroidism with Radioactive Iodine (RAI) ablation therapy has been associated with weight gain from RAI induced hypothyroidism. Literature on weight data of post-RAI patients following normalisation of thyroid function is equivocal.Objective: We undertook a retrospective study to evaluate the effect of RAI on weight in Hyperthyroid patients in University Hospitals of Leicester NHS Trust (UHL). <p class="abst...

ea0077cc6 | (1) | SFEBES2021

Monozygotic twins with hypothyroidism responding to T3/T4 combination: a role for Nuclear Factor-kappa B (NF-κB)?

Al Jumaah Ali , Reddy Narendra , Levy Miles , Barwell Julian , Twiss Philip , Wilding John , Bhake Ragini

Introduction: There are patients who remain symptomatic with hypothyroidism despite apparent adequate replacement on levothyroxine (LT4) therapy. We present an observation where monozygotic twins responded only to combination therapy with liothyroinine (LT3), and were found to have a genetic variation which may have clinical significance in thyroid metabolism.Case report: A 47-year-old female with polyglandular auto-immune syndrome (APS1) presented with ...

ea0081p383 | Endocrine-Related Cancer | ECE2022

Circulating cell-free tumour DNA (ctDNA) utilisation in diagnosis and monitoring of thyroid cancer response to treatment - systematic review

Al Jumaah Ali , Levy Miles J , Reddy Narendra , Bhake Ragini , Gohil Shailesh

Thyroid cancer is the most common endocrine malignancy accounting for 1% of new cancer cases each year. Even after treatment, one in five patients develop recurrence eventually. Therefore, close follow up is crucial after treatment. Current tumour biomarkers are not perfect, and there is a need for a more sensitive and specific way of detecting early recurrence. Liquid biopsies have emerged as a novel marker in tumour surveillance and monitoring response to treatment. In parti...

ea0086p47 | Endocrine Cancer and Late Effects | SFEBES2022

A Rare Occurrence of Phaeochromocytoma in an Adult with Previously Diagnosed Wilms Tumour - Case Report

Al Jumaah Ali , Gohil Shailesh , Levy Miles J , Reddy Narendra L , Bhake Ragini

Introduction: Phaeochromocytoma affects <1:100000 people per year. Wilms tumour (WT) affects almost 1:10000 children each year. Both tumours are associated with somatic genetic alterations: Phaeochromocytoma (RET, VHL, NF1, SDHA, SDHAF2, SDHB, SDHC, SDCD, TMEM127 and MAX); WT (WT1, 11p13, 11p15, tp53, NSD1, KDM3B, BRCA2). Both tumours affecting the same person have only been reported twice in the literature.Case Report: We report a lady who, at the a...

ea0094p120 | Reproductive Endocrinology | SFEBES2023

48,XYYY – a rare case in our endocrinology clinic

Al Jumaah Ali , Levy Miles , Gohil Shailesh , Barwell Julian , Bremner Emma , Barrowcliffe Mary , Reddy Narendra

Introduction: 48,XYYY is a rare condition where two extra Y chromosomes alter the neurological, skeletal and reproductive development of the affected individual. Clinical features are usually subtle and the diagnosis is not suspected until fertility issues arise. Here, were report an adult patient with 48,XYYY in the Endocrinology Clinic.Case report: A 24-year-old male was referred to UHL Endocrinology Clinic following i...

ea0094p173 | Adrenal and Cardiovascular | SFEBES2023

A rare case of hydatid cyst disease in the adrenal gland

Al Jumaah Ali , Levy Miles , Gohil Shailesh , Bhardwaj Neil , Wiselka Martin , Bremner Emma , Barrowcliffe Mary , Reddy Narendra

Introduction: Hydatid cysts disease (HSD) is a parasitic disease caused by echinococcus granulosus. It is common in areas where the parasite is endemic; North Africa, the Middle East, Central and Far Asia, Central America and Australia. Liver (44-77%) and lungs (10-50%) are the preferred locations for HSD. Here we report a rare case of HSD affecting the adrenal gland.Case report: A 62-year-old female complained of right ...

ea0086p184 | Bone and Calcium | SFEBES2022

Post-Operative Bone Health Assessment and Optimisation Remains Suboptimal in Primary Hyperparathyroidism

Al Jumaah Ali , Safwan Luqman , Antwi Kofi , Zaman Sajnin , Conboy Peter , Rahman Faizanur , Patel Prashanth , Gohil Shailesh , Bhake Ragini , Levy Miles , Reddy Narendra

Background: One of the main indications for parathyroidectomy surgery in primary hyperparathyroidism (PHPT) is osteoporosis. NICE guideline recommends 2-3 yearly Dual-energy X-ray absorptiometry (DEXA) assessments to evaluate bone mineral density (BMD) in asymptomatic PHPT. Objective: We undertook an audit to evaluate bone health practice in PHPT patients in line with NICE guidelines.Methodology: Retrospective case notes and electr...