Searchable abstracts of presentations at key conferences in endocrinology

ea0032p196 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Perturbed sympatho-vagal balance in Turner syndrome: relation to phenotype and aortic dilation

Trolle Christian , Mortensen Kristian Havmand , Hjerrild Britta , Andersen Niels Holmark , Gravholt Claus Hojbjerg

Objective: The risk of aortic dissection is 100-fold increased in Turner syndrome (TS). Increased blood pressure (BP) and heart rate is present as well as an increased risk of ischemic heart disease and diabetes. This study aimed to prospectively assess heart rate variability (HRV) in TS and its relation to aortic dimensions.Methods: Adults with TS (n=91, aged 37.4±10.4 years) recruited through the Danish National Society of Turner Syndrome...

ea0032p176 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Long QT interval in Turner syndrome: a high prevalence of LQTS gene mutations

Trolle Christian , Mortensen Kristian Havmand , Pedersen Lisbeth Norum , Jensen Henrik Kjaerulf , Andersen Niels Holmark , Gravholt Claus Hojbjerg

Objective: QT interval prolongation of unknown aetiology is common in Turner syndrome (TS). This study set out to explore the presence of known pathogenic long QT (LQT) mutations in TS and to examine the corrected QT interval (QTc) over time and relate the findings to the TS phenotype.Methods: Adult females with TS (n=102) were examined thrice with a mean follow-up of 4.7±0.5 years, and 68 age-matched healthy controls were examined once. QT...

ea0014p67 | (1) | ECE2007

Intravenous constant ghrelin infusion in healthy young men: sustained cardiovascular effects of supraphysiological ghrelin levels

Vestergaard Esben Thyssen , Andersen Niels Holmark , Hansen Troels Krarup , Rasmussen Lars Melholt , Moller Niels , Sorensen Keld , Sloth Erik , Christiansen Jens Sandahl , Jorgensen Jens Otto Lunde

Objective: The short-term cardiovascular effects of continuous ghrelin infusion in healthy humans remain to be studied.Methods: Fifteen healthy, young and normal-weight men volunteered to participate in a randomized double-blind, placebo-controlled cross-over study. The local ethics committee approved the study. We used a constant infusion of human ghrelin at a rate of 5 pmol/kg body weight per minute for 180 minutes and measured peak left ventricular my...