Endocrine Abstracts

Introduction: Dopamine agonists, mainly cabergoline and bromocriptine, represent the first-line treatment option in the management of prolactinomas. They allow prolactin normalization and tumor shrinkage. However, a subset of individuals with macroprolactinoma could exhibit a varying degree of resistance to dopamine agonists. The aim of this study was to determine the prevalence of dopamine agonist-resistance in patients with macroprolactinoma and to assess its predictive fact...

Introduction: The diagnosis of primary hyperparathyroidism and hypoparathyroidism is still challenging because of the increasing frequency of non-classical presentations. The calcium-to-phosphorus ratio (Ca/P) (CPR) is an inexpensive biochemical marker that could be useful to diagnose parathyroid disorders.Aim: The aim of this study was to assess the performances of CPR in the diagnosis of primary hyperparathyroidism and hypoparathyroidism.<p class="...

Introduction: Primary hyperparathyroidism is a common endocrine disease. Its association with inflammatory and thrombotic events was rarely reported in the literature. The pathophysiological mechanisms of this association remain uncertain. Herein, we report a case of hypercalcemia secondary to primary hyperparathyroidism revealed by a deep vein thrombosis.Observation: A 65-year-old patient was referred to our department for primary hyperparathyroidism. T...

Introduction: Polyuria-polydipsia syndrome (PUPDS) requires a comprehensive diagnostic approach as it can reveal serious medical conditions. We report the case of a patient consulting for PUPDS related to a primary potomania. Case presentation: A 41-year-old patient with a history of multiple psychostimulants use was admitted for acute PUPDS after emotional shock and paucisymptomatic SARS-CoV-2 infection. Diuresis was estimated at 6 liters per 24 hours. ...

Introduction: Sheehan’s syndrome (SS) is characterized by a deficiency in pituitary hormone secretion. It is now being closely inspected for its implication in the onset of metabolic syndrome (MS). The aims of this study were to determine the prevalence of MS and assess its associated factors in women with SS.Methods: We carried out a cross-sectional study involving 50 patients diagnosed with SS and 50 controls, matched for age and body-mass index (...

Introduction: Cushing’s syndrome (CS) has relevant morbidity and mortality and poses several diagnostic challenges underlining the need for a prompt diagnosis in order to initiate earlier treatment. The aim of the present study was to develop a new clinical and biological score to predict the diagnosis of CS.Methods: This was a monocentric retrospective study including patients who were admitted to the Department of Endocrinology of La Rabta Hospita...

Introduction: Adrenal incidentalomas (AI) are adrenal masses detected on imaging performed for reasons other than suspected adrenal disease. It is important to categorize whether the mass is a functioning or non-functioning incidentalomas to determine the appropriate management and follow-up. The aim of this study was to assess demographic, clinical, and paraclinical features of patients with AI.Methods: This was a monocentric retrospective study includi...

Introduction: Pheochromocytoma is a rare tumor originating from chromaffin cells of the adrenal medulla secreting catecholamines. The typical symptoms of pheochromocytoma include hypertension, headache, heart palpitations, anxiety, and profuse sweating. However, some patients with pheochromocytomas remain asymptomatic. The aim of this study was to determine the clinical and paraclinical characteristics of incidentally discovered pheochromocytomas.Methods...

Introduction: Hypothyroidism is a prevalent endocrine disease among the elderly. The thyroid hormones have a wide range of effects on the body, and hypothyroidism can significantly impact both physical and mental functions. The objectives of this study were to evaluate the quality of life in patients over 65 years old with substituted hypothyroidism and to assess their relationship with Thyroid Stimulating Hormone (TSH) level.Methods: The study was a cro...

Introduction: In patients with Graves’ disease, uncontrolled thyrotoxicosis causes liver dysfunction in 37 to 78% of cases. This is commonly revealed by abnormal elevation of liver enzymes including hepatic cytolysis and cholestasis. The aim of the present study was to determine the prevalence of liver dysfunction and its associated factors in patients with Graves’ disease.Methods: This was a monocentric retrospective study including 108 patien...