Searchable abstracts of presentations at key conferences in endocrinology

ea0011s89 | Contrasting practices in European endocrinology | ECE2006

Diagnosis of hypercortisolism

Atkinson AB

The diagnosis of Cushing’s syndrome firstly involves making or excluding the diagnosis. If the diagnosis is confirmed then an accurate diagnosis is needed as treatment modalities are in general specific to the aetiology. The diagnosis can be straightforward when symptoms and signs are classical and advanced. In these patients 24 h urinary free cortisol levels are markedly raised, late evening serum and salivary cortisol levels are raised and there is failure to suppress s...

ea0085p86 | Thyroid | BSPED2022

Congenital hypothyroidism: should radioisotope scanning be made mandatory to improve etiological diagnosis?

Atkinson Darcey , Goyal Sunil

Aim: To evaluate current practices relating to diagnosis and treatment of congenital hypothyroidism (CHT) in Aneurin Bevan University Health Board (ABUHB) compared to national guidelines and the use of radioisotope scanning in improving etiological diagnosis.Method: This service evaluation used a database of paediatric hypothyroid patients in ABUHB. Only children with CHT were included and any children born before January 2014 were excluded. 30 children ...

ea0009p12 | Diabetes and metabolism | BES2005

Refractory hypertension can often be helped by the use of the potent vasodilator minoxidil: results in 13 patients, 12 of whom were already receiving angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists

Black R , Hunter S , Atkinson A

The vasodilator minoxidil is a potent antihypertensive agent. However, its use has been rather limited and it can easily be overlooked in the era of ACE inhibition and angiotensin receptor blockade. It must be used with diuretic and beta-blocker cover.We reviewed 13 male patients with refractory hypertension attending our hypertension clinic from January to July 2004 and currently receiving minoxidil. Analysis was with paired t-tests.<p class="abstex...

ea0007p212 | Steroids | BES2004

Role of PPAR-gamma receptor agonist therapy in two patients with newly diagnosed pituitary-dependent Cushing's syndrome

Hull S , Sheridan B , Atkinson A

Existing treatments for pituitary-dependent Cushing's Syndrome include pituitary or adrenal surgery, pituitary irradiation and medical therapy. Pituitary microsurgery is the usual therapy of first choice but is not always successful in achieving early apparent remission and is associated with significant late relapses. An effective drug therapy for humans would be a major advance as there is significant morbidity and mortality in Cushing's Syndrome. Recent elegant in vitro and...

ea0003p38 | Clinical Case Reports | BES2002

Sustained improvement in vision in a recurrent growth hormone secreting macroadenoma during treatment with octreotide in the absence of marked tumour shrinkage. A reason for cautious optimism ?

Harding J , Sheridan B , Atkinson A

A 45-year-old lady presented with a 12-month history of blurred vision. Visual assessment revealed a bitemporal hemianopia and CT scan demonstrated a large pituitary tumour with lateral and suprasellar extension. A GTT showed her growth hormone was raised basally at 7.5 milliunits per litre and incompletely suppressed to 5.7 milliunits per litre confirming acromegaly. Transsphenoidal hypophysectomy was performed. Histology confirmed a somatoptroph adenoma. Post operatively she...

ea0003p39 | Clinical Case Reports | BES2002

Hyperprolactinaemia in a patient taking the herbal remedy Agnus Castus

Harding J , Sheridan B , Atkinson A

A 34-year-old woman, presented to her General Practitioner with hot flushes. Investigations showed her to have a normal LH, FSH, free T4 and TSH. Her prolactin was elevated at 1110 milliunits per litre (NR <350 ). She had a normal menarche age 14 and had regular 28 day menstrual cycles. Before the onset of the hot flushes she had started to take agnus castus, a herbal remedy said to help symptoms of premenstrual tension.Whilst she continued to take ...

ea0049ep926 | Pituitary - Basic | ECE2017

Angiogenesis-related proteins in pituitary adenomas

Karabid Ninelia Minaskan , Atkinson Michael , Pellegata Natalia

Pituitary adenomas are frequent intracranial tumors that often associate with the hypersecretion of pituitary hormones or may be non-secreting (nonfunctioning pituitary adenomas, NFPA). Tumors resembling human NFPAs develop with complete penetrance in rats affected by the multiple endocrine neoplasia syndrome, MENX. This syndrome is caused by a germline loss of function mutation in p27Kip1. Gene expression array analysis performed in our group identified a considera...

ea0034p94 | Clinical practice/governance and case reports | SFEBES2014

An unusual case of recurrent hypercalcaemia: sleeping parathyroid hyperplasia?

Graham Una , Eatock Fiona , Atkinson Brew

A 60-year-old man presented with symptomatic primary hyperparathyroidism. At this time serum corrected calcium was 3.1 mmol/l (2.15–2.65 mmol/l) and after investigation bilateral parathyroid exploration was performed. A suspected adenoma was identified in the right inferior gland and removed. The remaining glands appeared normal. The adenoma was confirmed histologically. Early post-operative calcium was normal (2.48 mmol/l).He remained well and calc...

ea0013p30 | Clinical practice/governance and case reports | SFEBES2007

Two cases of “idiopathic” hypopituitarism – Was more intensive investigation required?

Lewis Anthony , Courtney Hamish , Atkinson Brew

Hypopituitarism usually is the result of a pituitary tumour or its treatment. If, however, pituitary imaging is negative then an alternative diagnosis should be sought. We present two patients initially diagnosed as idiopathic hypopituitarism in whom the underlying diagnosis was delayed with potentially serious consequences.The first case was of a 32 year old male who presented with symptoms and signs of hypogonadism. Serum testosterone (<0.7 nmol/L)...

ea0007p272 | Clinical case reports | BES2004

Myxoedema coma with pericardial effusion and respiratory arrest in a 59-year-old woman

Mackay E , Kennedy A , Dalzell G , Atkinson A

A 59-year-old lady presented with 2 days of increasing confusion, hallucinations and drowsiness. Her family reported lethargy, weight gain and changing appearance over several months.On examination she was profoundly hypothyroid with typical coarsened facial features and dry skin. She had pulsus paradoxus, BP 120/70mmHg and Glasgow coma scale was 11/15. She was transferred to our care.Free thyroxine was <3.0pmol/L and TSH 30.8mu...