Searchable abstracts of presentations at key conferences in endocrinology

ea0004oc22 | Steroid hormone action | SFE2002

Agonist activated adrenocorticotropin receptor internalises via a clathrin-mediated G-protein coupled receptor kinase dependent mechanism

Baig A , Hunyady L , Clark A

The physiological effects of the pituitary hormone, adrenocorticotropic hormone (ACTH) on the adrenal are mediated by the melanocortin 2 receptor (MC2R), a G protein coupled receptor (GPCR) that signals via adenylate cyclase to elevate intracellular cyclic AMP (cAMP) levels. Therefore the expression and function of the receptor are likely to be the major determinants of the response to ACTH. Following repeated stimulation, the cAMP signal is diminished or desensitised. Desensi...

ea0086p359 | Reproductive Endocrinology | SFEBES2022

A rare case of male infertility; XX male syndrome

A H Mohamed Areej , Hutchinson Ben , Baig Irfan

Introduction: The XX male syndrome occurs in 1 in 20,000 births. This syndrome results from crossover between the X and Y chromosomes, which transfers the sex-determining region of the Y chromosome to the X chromosome. They lack the azoospermia factor region of the Y chromosome, which is essential for spermatogenesis; thus causing infertility.Case Description: 34-year-old gentleman was referred to endocrinology clinic for infertility and semen analysis s...

ea0038p50 | Clinical practice/governance and case reports | SFEBES2015

Early post-operative aldosterone concentration can be used to assess outcome from adrenalectomy in aldosterone producing adenoma

Baig Irfan , McGowan Barbara , Powrie Jake , Hubbard Jonathan , Carroll Paul

Introduction: Primary hyperaldosteronism (PHA) accounts for 5–13% of all hypertension and up to 20% of resistant hypertension. Aldosterone producing adenomas (APA) account for 60% of PHA and surgical resection in these patients can be curative. There is no consensus on the need for and duration of follow-up after adrenalectomy. This study assessed the immediate effect of unilateral adrenalectomy for APA on the serum potassium, renin and aldosterone levels. Acute effects o...

ea0031p59 | Clinical practice/governance and case reports | SFEBES2013

Outcomes of transsphenoidal surgery (TSS) for acromegaly

Baig Irfanulla , Hafeez Kashif , Velusamy Anand , Crown Anna

Background: Pituitary surgery is the initial treatment for the majority of patients with acromegaly. The UK acromegaly register data (UK-AR-2) suggests that surgical remission rates vary widely, with a marked improvement since 2000. The aim of this study was to assess the outcomes of first TSS for acromegaly in our centre over the past 5 years.Methods: We retrospectively analysed data for all acromegaly patients who underwent first TSS between 2007-2011....

ea0011p641 | Neuroendocrinology and behaviour | ECE2006

Endocrine abnormalities are common in transsexual individuals

Iqbal SJ , Baig H , Green R , Barrett J , Seal LJ

Background: The most significant hypotheses regarding biological causes of transsexualism are based on the role of environmental hormonal exposure on neural development.Aim: This study was to analyse the baseline hormonal results in a population of transsexuals attending a single clinic to identify any abnormalities in hormone levels in these individuals.Method: A retrospective cohort study was carried out using data collected from...

ea0011p643 | Neuroendocrinology and behaviour | ECE2006

Complications of hormonal therapy in male to female transsexuals is uncommon

Baig H , Iqbal SJ , Green R , Barrett J , Seal LJ

Background: Transsexuals in Britain are prescribed hormones as part of Gender Reassignment Treatment. Oestrogen therapy is associated with the development of deep vein thrombosis (DVT) with a 25 fold increased risk, and breast cancer; particularly in the older age group and smokers.Aims: To investigate the risk of developing deep vein thromboses in male to female transsexual patients who are, or have been, on oestrogen therapy, and seeing if this differs...

ea0086p309 | Adrenal and Cardiovascular | SFEBES2022

Case of herbal tea causing severe hypokalaemia and hypertension

Nizami Atif , Bilal Aziz Mohammed , Hasan Ahmed Ikram , Baig Irfan

Liquorice intake is an uncommon but familiar cause of hypokalaemia and hypertension. Liquorice tea is available over the counter as herbal tea to promote general wellbeing. This case report describes a 64-year-old male patient who presented to hospital with severe hypokalaemia and hypertension. During the in-patient stay, patient was managed with potassium replacement and anti-hypertensives (avoiding medications that interfere with endocrine investigations), investigations wer...

ea0056p81 | Adrenal medulla | ECE2018

A retrospective audit on the peri-operative management of phaeochromocytomas: “Phenoxybenzamine or Doxazosin”?

Ni Lee Yun , Casey Edel , Baig Mirza Asfand , Wickramsinghe Sasala , Jones Stuart , Nagy Zoltan , Syed Imran , Kelkar Anand , Stojanovic Nemanja , Pittathankal Antony , Tanday Raj , Nikookam Khash

Phaeochromocytomas are rare catecholamine secreting tumours with an incidence of 1:4500–1:1700 in the United States. Doxazosin and Phenoxybenzamine are alpha-1 selective and non-selective alpha blockers respectively which are commonly used to treat this condition peri-operatively. There are no randomized controlled studies comparing the effectiveness of these two medications. However, there are retrospective studies comparing these two medications; some favouring alpha-1 ...