Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc1.6 | Endocrine Tumours | ECE2009

Implication of the Wnt/β-catenin signaling pathway activation in the adenoma and in the malignant adrenocortical cancer

Czarnocka Barbara , Kasperlik-Zaluska Anna , Bardadin Krzysztof , Roszkowska Katarzyna , Cichocki Andrzej

The commonly expressed multifunctional protein and protooncogene β-catenin displays important functions in cell–cell adhesion and in the Wnt signaling pathway. Transforming activity of the Wnt/β-catenin pathway is thought to be involved in the development of a variety of human cancers and many β-catenin target genes have been shown to play critical functions in tumors. Therefore, the aim of this project was to determine the expression levels and cellular di...

ea0016p687 | Thyroid | ECE2008

Expression of RNA-binding proteins TIAR and TIA-1 in thyroid tissues from patients with immune and non-immune thyroid diseases

Bossowski Artur , Czarnocka Barbara , Bardadin Krzysztof , Urban Miroslawa , Czerwinska Jolanta , Lyczkowska Anna , Dadan Jacek

TIAR and TIA-1 are two closely related RNA-binding proteins, which possess three RNA recognition motifs (RMMs). These proteins are involved in several mechanisms of RNA metabolism, including regulation of mRNA translation. In cellular apoptosis continuously TIAR shuttled between the cytoplasm and nucleus.The aim of this study was to estimate expression of closely related mRNA binding proteins TIAR and TIA-1 in thyroid tissues from young patients with Gra...