Searchable abstracts of presentations at key conferences in endocrinology

ea0086p122 | Reproductive Endocrinology | SFEBES2022

Are elevated red blood cell parameters coincidental or correlated in patients with Turner syndrome?

D S A Dilrukshi M , Beck K , Roy N , Turner H E

Introduction: Long-term increased morbidity and mortality in Turner Syndrome (TS) due to vascular disease is recognized, and suggested risk factors include metabolic parameters and possible change in haemostasis, however elevated red cell parameters in women with TS have not previously been noted.Methods: Following an observation of unexplained occurrence of elevated hemoglobin, a quality improvement-project was conducted to retrospectively review full b...

ea0011p356 | Diabetes, metabolism and cardiovascular | ECE2006

Noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS) caused by an activating glucokinase mutation

Christesen HBT , Brusgaard K , Beck-Nielsen H , Malec J , Brock Jacobsen B

NIPHS is a rare cause of adult onset hyperinsulinaemic hypoglycaemia with islet hypertrophy/nesidioblastosis, but without mutations in the ABBC8 and KCNJ11 genes coding for the beta cell KATP-channel subunits SUR1 and Kir6.2. NIPHS patients with GCK mutations have never been described.We report of a 42-y-old woman with asymptomatic hypoglycaemia down to 2.9 mmol/l with simultaneous p-insulin 208 pmol/l (12–77 pmol/l), p-C-peptide 1574 pmo...

ea0077op2.2 | Adrenal and Cardiovascular | SFEBES2021

Single-centre analysis of 900 short synacthen tests: do pre-test clinical or biochemical variables predict failure?

Dilrukshi M D S A , Beck K J , Loo H , May C , Jafar-Mohammadi B , Pofi R , Tomlinson J W , Pal A

Short synacthen test (SST) is the most widely used dynamic test of hypothalamic-pituitary-adrenal (HPA) axis function. It’s simple to conduct but requires nursing time and is relatively costly given 15-fold price increase in synacthen since 2015. We audited our SST use with the aim of reviewing clinical indications for testing and identifying useful predictors of test outcome. Baseline referral, clinical and biochemical data were retrospectively collected for individuals ...

ea0049ep802 | Nuclear receptors and Signal transduction | ECE2017

5α-THB as a novel anti-inflammatory drug: The roles of the glucocorticoid and mineralocorticoid receptors

Abernethie Amber , Gastaldello A , Morgan RA , Mitchell C , McInnes KJ , Beck K , Odermatt A , Houtman R , Melchars D , Meijer OC , Hadoke PWF , Livingstone DEW , Walker BR , Andrew R

Glucocorticoids (GC) are potent anti-inflammatory compounds, acting mainly through the glucocorticoid receptor (GR). GC therapy, however, has debilitating side-effects, necessitating safer new alternative therapies. The natural GC metabolite 5α-Tetrahydrocorticosterone (5αTHB) is anti-inflammatory in vivo in mice, but with fewer side-effects. Its mechanism of action is unknown, and here we test signalling via GR and the mineralocorticoid receptor (MR). 5&#94...