Searchable abstracts of presentations at key conferences in endocrinology

ea0086op5.2 | Bone and Calcium | SFEBES2022

Hyperparathyroidism jaw tumour syndrome due to a novel familial CDC73 germline mutation

Alameri Majid , Behary Preeshila , Comninos Alexander N , Cox Jeremy

Introduction: Approximately 5-10% of PHPT cases are hereditary. One such hereditary cause of PHPT is Hyperparathyroidism-jaw Tumour Syndrome (HPT-JT) caused by an autosomal dominant mutation in cell division cycle 73 (CDC73) that impairs parafibromin, a protein with antiproliferative activity. HPT-JT is characterised by parathyroid tumours, ossifying jaw fibromas, renal tumours and uterine tumours. We report a familial case of HPT-JT caused by a novel CDC73 mutation.<...

ea0062p41 | Poster Presentations | EU2019

An Interesting case of Transient Graves’ Ophthalmopathy on the background of Hashimoto’s Thyroiditis

Zaman Shamaila , Behary Preeshila , Khalid Neelam , Todd Jeannie

Case History: A 30 year old woman presented with the history of swollen painful eyes for 4 weeks while visiting Italy. She had a background of Hashimoto’s Thyroiditis since 2010 and was treated with levothyroxine 100 mcg once daily. She was given a course of oral steroids for 2 weeks and her thyroxine dose was reduced to 25 mcg once daily in Italy. Since then, her orbital swelling began to improve. She was a non-smoker. On examination, she was noted to have bilateral mild...

ea0062cb9 | Additional Cases | EU2019

To treat or not to treat: Two interesting cases of Alemtuzamab related Thyroid disorder

Zaman Shamaila , Khalid Neelam , Behary Preeshila , Todd Jeannie

Alemtuzumab, a humanized anti-CD52 monoclonal antibody is effective in treating multiple sclerosis. However, it has been associated with thyroid disorder in up to 30–40% patients. While Graves’ disease is the most common disorder (70%), thyroiditis has been reported up to 4.9% cases.Case 1: 34 year old woman with the background of multiple sclerosis and autoimmune hypothyroidism (on levothyroxine 50 mcg OD) was given Alemtuzumab infusion in Jul...

ea0034p279 | Pituitary | SFEBES2014

An unusual cause of pituitary apoplexy

Behary Preeshila , Townsey Gareth , Mehta Amrish , Meeran Karim

Hypopituitarism secondary to pituitary apoplexy is a rare but recognised complication following cardiac surgery but not cardiac arrest.We present a case report of acute pituitary apoplexy following a cardiac arrest on a background of sepsis. A 65-year-old gentleman presented with 3-day history of abdominal pain and vomiting. Of note, he underwent an appendicectomy 2 months earlier. He was septic and investigations revealed bowel perforation with faecal p...

ea0094cc4 | Section | SFEBES2023

A rare cause of hypercalcemia, unmasked by over-the-counter vitamin D supplementation

Mateen Abdul , Comninos Alexander , Cox Jeremy , Choudhury Sirazum , Behary Preeshila

Background: Mutation in the CYP24A1 gene can have variable phenotypes including infantile hypercalcemia and adult-onset hypercalcemia, hypercalciuria, nephrocalcinosis, or nephrolithiasis. CYP24A1 gene mutation is a rare but important cause of PTH-independent hypercalcemia.Case Presentation: We describe a case of a 67-year-old gentleman who presented with lethargy, fatigue and weight loss. He was found to have PTH-indepe...

ea0094p322 | Bone and Calcium | SFEBES2023

Osteoporosis in a young male patient

Tsoutsouki Jovanna , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 58 year-old man presented with backache and was found to have T10-T12 vertebral fractures on spinal-MRI. He was diagnosed with osteoporosis on a DEXA-scan (lumbar-spine T-score-2.6) and was treated with Alendronate and Cholecalciferol at a neighboring hospital. He was referred to the endocrine bone-clinic for a second opinion regarding his osteoporosis. He had a history of multiple small bone fractures and Brucellosis that required a 2-month bed-rest. His family history incl...

ea0091wf3 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2023

Differentiating Primary Hyperparathyroidism from Familial Hypocalciuric Hypercalcaemia Can Be Difficult: A Misleading Urinary Calcium to Creatinine Clearance Ratio

G Mills Edouard , J Hadjiminas Dimitri , Abbara Ali , Behary Preeshila , Cox Jeremy , N Comninos Alexander

Case: We report a 79-year-old female who was referred to our Endocrine Bone Unit with osteoporosis, which was initially treated with Alendronate (but poorly tolerated due to dyspepsia) followed by annual Zoledronate infusions. Her bone history was significant for a proximal humeral fragility fracture 30-years previously. She was an ex-smoker, had limited dietary calcium intake, and had a brother with osteoporosis. DEXA demonstrated T scores at lumbar spine -1.8, total hip -2.0...

ea0091cb58 | Additional Cases | SFEEU2023

Hypercalcaemia in a young female patient

Tsoutsouki Jovanna , North Matthew , Tebbs Daniel , Tharakan Goerge , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 35 year old lady presented with a one week history of back pain, myalgia, fatigue, epigastric pain, and persistent vomiting. She reported a four week history of reduced appetite and 4 kg weight loss. She had recently recovered from an uncomplicated COVID-19 infection. Past medical history included a previous eating disorder (anorexia and bulimia), and subsequent chronic gastritis. Drug history included Omeprazole 20 mg daily, Laxido 2 sachets daily and antacids (Rennies 4-8 ...

ea0065op3.3 | Metabolism and Obesity | SFEBES2019

The impact of subcutaneous infusions of three anorexigenic gut hormones glucagon-like peptide-1, oxyntomodulin and peptide YY (GOP) on the psychological health of obese diabetic patients

Alessimii Haya , Behary Preeshila , Tharakan George , Alexiadou Kleopatra , Chedie Doyle , Bloom Stephen , Tan Tricia , Scholtz Samantha

Introduction: Obesity-associated psychopathological co-morbidities have a negative impact on quality of life. Roux-en-Y gastric bypass surgery (RYGB) has been shown to ameliorate psychological health, however, the underlying mechanisms are not fully understood. Changes in gastrointestinal and central neuroendocrine signalling have been postulated as mediators of psychological and eating behaviour changes following RYGB. Here we assess the impact of subcutaneous infusions of th...

ea0034p111 | Clinical practice/governance and case reports | SFEBES2014

A rare case of Cushing's syndrome caused by ‘cyclical’ ectopic ACTH secretion

Behary Preeshila , Kadiyala Raghunath , Falinska Agnieszka , Beckwith Hannah , Jackson James , Mitchell Catherine , Todd Jeannie F

A 61-year-old lady presented with rapid onset of lethargy and reduced mobility with inability to use stairs over 1 month. Prior to this, she was fit and well and was a lifelong non-smoker. At presentation, she was overweight and had evidence of skin bruising and severe proximal myopathy of her legs. A midnight cortisol was >1710 nmol/l with a corresponding ACTH of 610 nmol/l confirming ACTH dependent Cushing’s syndrome. Serum potassium was 2.6 mmol/l and a new diagnos...