Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc5.2 | Thyroid: Basic and Clinical | ECE2009

Selenium and iodine determination from single murine thyroid lobes by TXRF-spectroscopy

Renko Kostja , Behrends Thomas , Stosnach Hagen , Kohrle Josef , Schomburg Lutz

Iodine (I) and selenium (Se) are two essential trace elements for regular thyroid gland functioning and thyroid hormone metabolism. Most Europeans are only marginally supplied with both elements through their daily nutrition. The mammalian organism has developed efficient and highly complex mechanisms to control I and Se uptake, metabolism and recycling. The thyroid gland is equipped with the necessary transporters and metabolizing enzymes for I uptake and bioconversion into t...

ea0020p685 | Signal Transduction | ECE2009

On the importance of the selenium status for the inflammatory response

Stoedter Mette , Renko Kostja , Behrends Thomas , Schomburg Lutz

Many endocrine disorders bear an immunological component and involve local cytokines as paracrine signals. Moreover, certain auto-antibodies appear as causative pathological agents in some of the most common endocrine diseases e.g. in type I diabetes mellitus or different forms of autoimmune thyroid disease (AITD). Recently, selenium (Se) status and selenoproteins have emerged as important modifiers of the inflammatory response, AITD or sepsis. Notably, mortality risk of patie...