Endocrine Abstracts

Introduction: Resistance to thyroid hormone beta is a genetic disease defined by impaired sensitivity of target tissue to thyroid hormone caused by mutation of thyroid hormone receptor beta gene, appearing with an incidence of 1/40,000. The characteristic biochemical profile of resistance to thyroid hormone is elevated serum thyroid hormone level and inappropriate serum level of thyrotropin (TSH) which is normal or elevated. Clinical picture is variable ranging from asymptomat...

Objective: A mesenteric mass with surrounding mesenteric fibrosis (MF) is a hallmark of small intestinal neuroendocrine tumours (SI-NETs) and known to induce abdominal complications. However, little is known on the evolution over time and the pathways involved in progression. Our aim was to assess the development of the metastatic mesenteric mass over time and find predictors for progression.Methods: Retrospectively, 530 patients with proven SI-NET and &...