Searchable abstracts of presentations at key conferences in endocrinology

ea0016p285 | Endocrine tumours | ECE2008

The role of parathyroid hormone-related protein on gynecomatia in patients with Klinefelter's syndrome and idiopathic gynecomastia

Deniz Ferhat , Bolu Erol , Azal Omer , Ozata Metin , Kutlu Mustafa

Background: Parathyroid hormone-related protein (PTHrP) was discovered as a tumor product. It is also one of the complex epithelial and mesenchymal interaction signal mediator in breast development. An increase in the prevalence of malignancy in patients with Klinefelter’s syndrome, but not in patients with idiopathic gynecomastia has been previously reported. PTHrP may play a critical role in the development or progression of breast cancer.Aim: We ...

ea0022p148 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Searching for the metabolic syndrome criteria in young adults with hypogonadism

Sonmez Alper , Haymana Cem , Bolu Erol , Tapan Serkan , Barcin Cem , Aydogdu Aydogan , Taslipinar Abdullah , Kutlu Mustafa

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

ea0022p162 | Cardiovascular endocrinology and lipid metabolism | ECE2010

The effect of testesterone replacement therapy on HDL subfraction levels in hypogonadotropic hypogonadism

Taslipinar Abdullah , Sonmez Y Alper , Bolu Erol , Tapan Serkan , Uckaya Gokhan , Aydogdu Aydogan , Kutlu Mustafa

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

ea0020p240 | Bone/Calcium | ECE2009

The effect of short term human chorionic gonadotropin treatment on the improvement of bone mass in patients with hypogonadotropic hypogonadism

Bolu Erol , Sonmez Alper , Apikoglu Mehmet , Gurel Hasan , Emer Ozdes , Taslipinar Abdullah , Ozguven M Ali , Kutlu Mustafa

Background: Idiopatic hypogonadotropic hypogonadism is a congenital abnormality due to GnRH deficiency which is associated with severe osteoporosis. Testosterone replacement has been shown to improve the loss in the bone mass. The aim of the present retrospective analysis was to measure the effect of human chorionic gonadotropin treatment on the improvement of bone mineral density.Methods: A total number of 96 young male (mean age 21±3.7 years) pati...

ea0032p186 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

The effect of testosterone replacement on endothelial dysfunction, inflammation and insulin resistance in male hypogonadotrophic hypogonadism

Sonmez Alper , Taslipinar Abdullah , Aydogdu Aydogan , Tapan Serkan , Meric Coskun , Basaran Yalcin , Sertoglu Erdim , Yilmaz Mahmut I , Serdar Muhittin A , Ozgurtas Taner , Bolu Erol , Kutlu Mustafa

Objective: Metabolic disorders are common in patients with hypogonadism. Testosterone replacement therapy (TRT) significantly improves symptoms of testosterone deprivation such as mood, libido or musculoscelatal power. However, whether the metabolic and cardiovascular risk is improved is not clearly known. We aimed to search for the metabolic and cardiovascular effects of TRT.Design: Prospective study, performed in the outpatient units of Gulhane Medical...

ea0032p193 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

HDL cholesterol subfractions and the effect of testosterone replacement in hypogonadism

Bolu Erol , Sonmez Alper , Tapan Serkan , Taslipinar Abdullah , Aydogdu Aydogan , Meric Coskun , Basaran Yalcin , Uckaya Gokhan , Serdar Muhittin A , Kurt Ismail , Azal Omer

Metabolic disorders and cardiovascular events are increased in hypogonadism. Serum HDL composition is a better cardiovascular predictor than the HDL counts. However, there is no information about the HDL subfractions in patients with hypogonadism. We designed a prospective study to investigate the HDL subfractions in treatment naïve subjects with hypogonadism and the effects of two different testosterone replacement regimens on the HDL subfractions. Seventy young male pat...