Searchable abstracts of presentations at key conferences in endocrinology

ea0022p135 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Insulin secretion and HOMA-IR in patients who underwent coronary angiography

Isailovic Tatjana , Petakov Milan , Ognjanovic Sanja , Macut DJuro , Popovic Bojana , Bozic Ivana , Elezovic Valentina , Damjanovic Svetozar

Introduction: Several population-based studies have shown that hyperinsulinemia and insulin resistance could be an independent predictive factor for development of coronary artery disease (CAD).Aim: The aim of this cross-sectional study was to analyze insulin secretion in patients with proven coronary artery disease.Methods: We have analyzed 151 consecutive patients (35–79 years old, men 68%, women 32%) referred for coronary a...

ea0022p169 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Bcl1 polymorphysm of glucocorticoid receptor gene in coronary artery disease

Popovic Bojana , Macut Djuro , Isailovic Tatjana , Bozic Ivana , Antic Jadranka , Ognjanovic Sanja , Petakov Milan , Damjanovic Svetozar

Introduction and aim: Obesity epidemic contributes to the increasing prevalence of high blood sugar, high blood pressure, and dyslipidemia, which are all known risk factors for coronary artery disease (CAD). Metabolic syndrome (MS) describes the common clinical finding wherein component CAD risk factors cluster within a single patient. Since obesity shares common clinical characteristics with both metabolic syndrome (MS) and Cushing’s syndrome it is speculated about obeso...

ea0022p243 | Clinical case reports and clinical practice | ECE2010

Nesidioblastosis in adult patient with neurofibromatosis type1 and synchronous multicentric duodenal somatostatinomas - case report

Ognjanovic Sanja , Petakov Milan , Macut Djuro , Isailovic Tatjana , Elezovic Valentina , Popovic Bojana , Bozic Ivana , Damjanovic Svetozar

Somatostatinomas are rare neuroendocrine tumors of the pancreas and small intestine that can occur sporadically or in a syndromic form. Duodenal somatostatinomas are often associated with neurofibromatosis type1 (NF1). Their presenting features are mostly related to local effects of the tumor mass rather than functional clinical syndrome. Nesidioblastosis is extremely rare cause of persistant hyperinsulinemic hypoglycaemia in adults.We present a case of ...

ea0022p439 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Cushing’s syndrome, clinicaly non-functioning pituitary adenoma and hypercalcemia

Elezovic Valentina , Isailovic Tatjana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Popovic Bojana , Bozic Ivana , Damjanovic Svetozar

A 25-year-old female, referred because of left hemianopsy, weight gain, fatigue, muscle weakness, and secondary amenorrhea. Physical examination revealed overt Cushingoid features and left temporal hemianopsy. Previously the diagnosis of pituitary macroadenoma (MRI) with suprasellar, infrasellar, and right parasellar propagation was made in regional hospital. Laboratory results showed moderate hypercalcemia with hypophosphatemia and hypercalciuria with inappropriately normal P...

ea0022p472 | Female reproduction | ECE2010

HPA axis function in obese women with PCOS

Bozic Ivana , Macut Djuro , Popovic Bojana , Isailovic Tatjana , Bogavac Tamara , Petakov Milan , Ognjanovic Sanja , Damjanovic Svetozar

Objectives: Besides well known increased adrenal androgen production, an enhanced peripheral cortisol metabolism was also observed in polycystic ovary syndrome (PCOS). This could induce a compensatory rise of ACTH secretion, tending to maintain normal plasma cortisol concentration at the expense of adrenal androgen excess. On the other hand, obesity is associated with a hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis and impaired androgen balance. In t...

ea0022p473 | Female reproduction | ECE2010

Metabolic syndrome indices and Framingham risk scoring in women with polycystic ovary syndrome

Macut Djuro , Bozic Ivana , Popovic Bojana , Bogavac Tamara , Petakov Milan , Ognjanovic Sanja , Isailovic Tatjana , Damjanovic Svetozar

Objectives: It is well known that polycystic ovary syndrome (PCOS) can promote metabolic syndrome (MetSy) and consequently cardiovascular diseases (CVD). In this study we compared indices of MetSy and 10-year cardiovascular risk (CVR10) based on Framingham risk scoring system (FRSS) in young obese PCOS women and healthy obese controls.Methods: We studied 25 obese women with PCOS (mean age: 29.55±4.6 years, mean BMI: 31.8±4.4 kg/m<sup...

ea0020p202 | Endocrine tumours and neoplasia | ECE2009

A National survey of neuroendocrine lung tumors

Popovic Bojana , Isailovic Tatjana , Bozic Ivana , Macut Djuro , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Damjanovic Svetozar

Neuroendocrine lung tumors represent approximately 20% of all lung tumors. They range from low-grade well-differentiated NETs and well-differentiated neuroendocrine carcinomas (typical and atypical carcinoids) to aggressive poorly differentiated small-cell and large-cell neuroendocrine carcinomas. They can develop different clinical syndromes due to ectopic hormone secretion.We analyzed 178 patients with neuroendocrine tumors (age range: 17–79 years...

ea0020p212 | Endocrine tumours and neoplasia | ECE2009

Pancreatic neuroendocrine tumors: a national survey

Isailovic Tatjana , Popovic Bojana , Petakov Milan , Ognjanovic Sanja , Macut Djuro , Bozic Ivana , Elezovic Valentina , Da Svetozar

Pancreatic neuroendocrine tumors (PETs) occurs in approximately 1 per 100 000 people per year and account for only 1–2% of all pancreatic tumors. Most of them are hormonally active, while about 30% secrete no detectable hormons and are discovered due to a tumor mass effect.Material and methods: We analysed 178 patients with neuroendocrine tumors (NETs) treated at our department in the last five years. The diagnosis was made by pathohistological exam...

ea0020p659 | Reproduction | ECE2009

Adiponectin levels and its relation to indices of insulin resistance in women with PCOS

Bozic Ivana , Macut Djuro , Popovic Bojana , Isailovic Tatjana , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Damjanovic Svetozar

Objectives: Insulin resistance and hyperinsulinaemia are implicated in the pathogenesis of the polycystic ovary syndrome (PCOS) in the majority of the cases. Adiponectin is adipose tissue-specific protein and its correlation with insulin resistance is well established. The aim of the study was to access the correlation between adiponectin and anthropometric and metabolic parameters in a group of women with PCOS.Methods: Thirty-one women with PCOS (age: 2...

ea0016p339 | Endocrine tumours | ECE2008

Fenotypes in patients with Y791F mutation of RET protooncogene

Isailovic Tatjana , Petakov Milan , Macut Djuro , Popovic Bojana , Bozic Ivana , Ognjanovic Sanja , Damjanovic Svetozar

Mutation Y791F of RET protooncogene is a well known mutation so far described in families with FMTC and familial pheochromocytoma in one family. It activates the receptor in a monomeric form. Here we present eight unrelated families with the same mutation but different fenotype expression.Patients and methods: In last 20 years, we analyzed 216 patients with MTC (age range: 3–75 years, 45.0 mean). Genetic testing for mutation in RET pro...