Searchable abstracts of presentations at key conferences in endocrinology

ea0031p66 | Clinical practice/governance and case reports | SFEBES2013

A very interesting presentation: VIP co-secretion by a phaeochromocytoma

Triay Jessica , Bradley Karin

A 62-year-old lady was assessed following discovery of a retroperitoneal tumour on a CT scan. Fifteen years previously she was diagnosed with irritable bowel syndrome with alternating constipation and diarrhoea, however, within the last 5 years, diarrhoea was the dominant feature with bowel opening every 20 min daily. Investigations for inflammatory bowel disease, hyperthyroidism and coeliac disease were negative. Her anal sphincter was found to be non-functioning and a colost...

ea0062wa6 | Workshop A: Disorders of the hypothalamus and pituitary | EU2019

Recurrence of Pituitary Apoplexy in non-functioning pituitary adenoma

Jagannatha Hema , Parfitt Vernon , Bradley Karin

79 year old gentleman was reviewed as new patient in the Endocrine clinic. He was diagnosed with Pituitary Apoplexy of a Non-functioning Adenoma in 1998. He was under surveillance and the tumour remained relatively stable with no complications until 2008.Surgical history: There was a gradual increase in the size of the adenoma over 5 years. He underwent Transphenoidal adenectomy in Feb 2014 as the tumour was draped over the optic chiasm. Intra-operativel...

ea0031p385 | Thyroid | SFEBES2013

Audit of use of radioactive iodine in the treatment of thyrotoxicosis at the Bristol royal infirmary (2008–2009)

Jitan John , Triay Jessica , Bradley Karin

Audit was performed to identify outcomes of patients from our department referred for RAI for thyrotoxicosis over 14 month period. Follow-up data of atleast 6 months was required for inclusion. Forty-eight patients were identified; four were excluded due to insufficient follow-up. Diagnoses were: Graves’ disease (n=35; 79.5%), multinodular disease (MND) (n=8; 18.2%) and Amiodarone induced thyrotoxicosis (AIT) (n=1; 0.02%)....

ea0059ep16 | Adrenal and steroids | SFEBES2018

Two cases of Addison’s disease in pregnancy

Sabin Jodie , Carroll-Moriarty Leigh , Thorogood Natasha , Bradley Karin

Addison’s disease rarely newly presents during pregnancy. We highlight two cases diagnosed within 3 months. A 41-year-old with mild depression on Sertraline, presented at 11-weeks’ gestation with an 8-week history of fatigue, weight loss, dizziness and vomiting. Persistent hyponatraemia was noted (Na 122–127 mmol/l). Random cortisols were 298–428 nmol/l. Sertraline withdrawal and fluid restriction at another centre did not improve her hyponatraemia, the use...

ea0031p276 | Pituitary | SFEBES2013

TSH-secreting pituitary adenoma identified in pregnancy: management of an unusual case

Triay Jessica , Wynick David , Thorogood Natasha , Bradley Karin

A 35-year-old woman was referred with biochemical hyperthyroidism (T4 30 pmol/l; T3 7 pmol/l) without TSH suppression (5.4 mIU/l). She was 7 weeks pregnant following natural conception, and reported no symptoms of hyperthyroidism. Migraines had been a feature in very early pregnancy, but her medical history was otherwise unremarkable and there was no significant family history. Examination findings were entirely normal.Investigation...

ea0025p256 | Pituitary | SFEBES2011

Hypertrophic pachymeningitis and pituitary pathology: lymphocyctic hypophysitis or cabergoline related fibrosis?

Raghavan Rajeev , Mallam Elizabeth , Scolding Neil , Bradley Karin

Case history: A 51-year-old lady with a background of classical migraine and amenorrhoea conceived successfully via IVF, without prior endocrine assessment. Symptoms during the third trimester of pregnancy led to the diagnosis of a pituitary mass lesion (see Table). Possible differential diagnoses, on subsequent endocrine review, included macroprolactinoma, microprolactinoma with expansion during pregnancy, or lymphocytic hypophysitis.After 6 years of do...

ea0039ep77 | Late effects of cancer treatment | BSPED2015

Impact of haematopoietic stem cell transplantation with total body irradiation on apparent bone mineral density in childhood leukaemia survivors

Wei Christina , Elson Ruth , Cox Rachel , Bradley Karin , Stevens Michael , Crowne Elizabeth

Background: Reduced bone mineral density (BMD) z-scores from Dual energy X-Ray absorptiometry (DEXA) have been reported in childhood HSCT survivors. However, BMD z-scores are unreliable in patients with short stature.Objective: To investigate the influence of HSCT/TBI on size-corrected BMD in childhood leukaemia survivors.Method: Post-pubertal leukaemia survivors (16–26 years) treated with HSCT/TBI (10–1...

ea0038p98 | Clinical practice/governance and case reports | SFEBES2015

Hyponatremia: an audit of the initial investigation and management

Ghaffar Imran , Downie Paul , Ahmad Bushra , Thorogood Natasha , Thomas Paul , Bradley Karin

Background: Hyponatremia is the commonest electrolyte abnormality encountered in clinical practice. It is associated with increased mortality and prolonged length of stay. Errors in establishing the aetiology of hyponatremia can lead to inappropriate treatment with adverse outcomes. An accurate diagnosis requires a careful clinical and biochemical assessment. An audit was undertaken to determine current practice at University Hospitals Bristol.Method: A ...

ea0036oc3.4 | Oral Communications 3 | BSPED2014

Standard population screening for diabetes mellitus has low sensitivity in identifying diabetes in adult survivors of childhood bone marrow transplantation with total body irradiation

Wei Christina , Unsworth Rebecca , Davis Nikki , Bradley Karin , Cox Rachel , Stevens Michael , Crowne Elizabeth

Background: Adult survivors of childhood leukaemia treated with bone marrow transplantation and total body irradiation (BMT/TBI) have an increased risk of diabetes mellitus (DM) disproportionate to their level of adiposity or other recognised risk factors. Post prandial hyperglycaemia due to reduced β-cell reserve after irradiation will be missed by fasting glucose (FG) levels. However, the UK National Institute of Clinical Excellence (NICE) screening guidelines recommend...

ea0033oc1.4 | Oral Communications 1 | BSPED2013

Abnormal glucose homeostasis in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation is associated with reduced β-cell reserve and pancreatic volume

Wei Christina , Thyagiarajan Manigandan , Hunt Linda , Bradley Karin , Elson Ruth , Cox Rachel , Stevens Michael , Crowne Elizabeth

Background: Adult survivors of childhood acute lymphoblastic leukaemia (ALL) treated with bone marrow transplantation (BMT) and total body irradiation (TBI) have increased risk of impaired glucose tolerance (IGT) and diabetes mellitus (DM). Insulin resistance (IR) has been described, but effects of TBI on pancreatic growth and β-cell function have not been previously reported.Method: Two groups of childhood ALL survivors were studied: Group 1, treat...