Endocrine Abstracts

Introduction: Diabetes mellitus (DM) results from a defect in insulin secretion and/or its action. The Breast-Cancer Susceptibility Gene 2 (BRCA2), like BRCA1, is a tumour suppressor gene, and its mutation is associated with an increased risk of breast cancer and, in males, testicular cancer. In patients with the BRCA1/2 mutation, the level of Insulin-like Growth Factor (IGF)-1 and, consequently, the peripheral sensitivity to insulin are reduced, suggesting that this ...

Introduction: Maturity-onset diabetes of the young (MODY) represents 1 to 2% of all cases of diabetes. MODY-3 is the most prevalent subtype and is characterized by a high sensitivity to sulfonylurea (SU) therapy. To date, we have scarce evidence about the efficacy of other therapies in this population, namely GLP-1 receptor agonists (GLP-1ra). Objective: Evaluate the metabolic impact of GLP-1ra use in MODY-3 patients.Methods: Retro...

Introduction: Thyroglossal duct cysts (TDC) are a very frequent congenital neck mass and are mostly benign. Papillary thyroid carcinoma (PTC) originating from a TDC represents an infrequent finding. Usually, the diagnosis is only made postoperatively after cyst’s excision.Case report: A 38-years old female patient was referred to the Endocrinology department due to Graves’ disease. She had been treated with antithyroid drugs for 18 months witho...