Endocrine Abstracts

Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency.Introduction: Congenital adrenal hyperplasia is a heterogenic group of disorders. Shared feature is a deficiency of one of the enzymes which are necessary for steroid synthesis. Due to wide clinical spectrum and rarity of the disease diagnosis can be challenging. Hereby we present the case of the patient, who after prolonged period of time was finally diagnosed with 3-be...

Introduction: Obstructive sleep apnea syndrome (OSAS) is characterized by chronic inflammation. Hepcidin is an acute-phase protein involved in iron metabolism. Increase in hepcidin has been shown in OSAS. Testosterone probably exerts inhibitory effect on hepcidin levels and even trump iron and inflammation-mediated mechanism in chronic inflammatory state. On the other hand iron balance may influence gonadal axis. The aim of this study was to assess whether hypogonadism in OSAS...

Introduction: Saliva is an interesting alternative to blood in clinical evaluation of endocrine function. Certain advantages of saliva collection must be considered, when comparing with conventional blood sampling. Vital arguments are that procedure is easy, non-invasive and stress-free. The studies on correlation between salivary and serum thyroid hormones are scarce and contradictory. The goal of our research was to assess if salivary thyroid hormone levels reflect serum con...

Introduction: Neuroendocrine tumors of the lungs comprise 20% of primary lung tumors. Nestin is an intermediate filament protein, expressed in stem cells during fetal development. It is also described as a potential cancer stem cell marker, angiogenesis marker and indicator of poorer survival probability for patients with some types of malignancies. Adversely, Klotho gene is a potential tumor suppressor. Aberrant expression of Klotho have been recently noticed in a number of c...