Endocrine Abstracts

Background: PD-L1 represents a novel class of drugs for treatment of a broad spectrum of malignancies including onco-hematologic diseases. This treatment is associated with several immuno-related adverse events (irAEs). Thyroid diseases and diabetes are among the most common PD-L1 endocrine-irAEs reported in solid cancers.Aims: To describe the frequency, the onset and the characteristics of PD-L1 endocrine-irAEs in patients with hematologic malignancies....

Background: In the last years, Pembrolizumab has been used to treat solid and lymphatic neoplasms, showing improved patients’ survival. Due to its mechanism of action, Pembrolizumab may be responsible of several immune-related adverse events (irAEs). The most frequent endocrine-irAEs reported are thyroid diseases.Aims: The aim of this study was to evaluate differences in thyroid disease incidence and presentation between patients treated for lung c...

EAT has been linked to the presence and severity of cardiovascular disease. EAT has been linked to the presence and severity of cardiovascular disease. We searched if the patients with PCOS have increased EATT, or not.Total of 41 subjects with PCOS and 46 age and body mass index (BMI) matched healthy controls were enrolled. EAT was measured by echocardiography.EATT and HOMA-IR score were significantly higher (P=0.0001 for bo...