Searchable abstracts of presentations at key conferences in endocrinology

ea0008s9 | Stressed mothers: Causes and outcomes | SFE2004


Pedersen CA

Decades of clinical experience and research in human and non-human primates demonstrate that maternal care received early in life strongly influences the development of parenting and other social skills as well as resiliency in the face of stress. Analogous intergenerational effects of maternal nurturing have recently been reported in rats. Adult stress responses (anxiety and hypothalamic-pituitary-adrenal axis activation) are inversely related to the amount of maternal lickin...

ea0011p256 | Diabetes, metabolism and cardiovascular | ECE2006

The effect, in clinical practice, of long-acting fluvastatin (LAF) on low density lipoprotein-cholesterol (LDL-Ch) in patients with type 2 diabetes mellitus (T2DM) in which other statins have failed to achieve the goals

del Cañizo-Gómez FJ

There is an association between high LDL-Ch levels and cardiovascular disease in T2DM patients. Clinical trials have shown that reduction of LDL-Ch with statins has a beneficial effect on macrovascular complications in patients with T2DM, but is this a relevant effect in clinical practice? LAF has a slower absorption, longer action time and less side effects than other statins.Objective: To assess in clinical practice, the effect of LAF on LDL-Ch and the...

ea0011p426 | Endocrine disruptors | ECE2006

Prevalence of the phyto-oestrogen urinary metabolites enterodiol and enterolactone in patients under endocrine investigation

Reilly L , Scobbie L , Dorrian CA , Wallace AM

Phyto-oestrogens are plant-derived compounds that have oestrogenic and/or anti-oestrogenic activity. They are constituents of many human foodstuffs but exposure is on the increase due to increasing availability of ‘herbal’ type medicines. The current study was initiated following the identification of large concentrations of lignan related phyto-oestrogen metabolites in the urine from a girl under investigation for precocious puberty.A GC-MS pr...

ea0011p778 | Thyroid | ECE2006

Prevalence of thyroid dysfunction in old residents in the province of Pavia, northern Italy

Magri F , Galimberti CA , Chytiris S , Chiovato L , Ferrari E

Thyroid dysfunction affects a considerable number of elderly subjects. However the role of screening and treatment of thyroid disorders in geriatric population is still debated. The aim of this study was the evaluation of the prevalence of thyroid dysfunction and its impact on comorbidity and comedication.Two independent populations were evaluated: 2001 residents in 21 federated nursing homes in the province of Pavia (Northern Italy), age >60 y, and ...

ea0008oc20 | Young Endocrinologist Session | SFE2004

Sp1/Sp3, GnRH and PACAP involvement in C-type natriuretic peptide (CNP/Nppc) expression and action in gonadotrophs

Fowkes RC , Burrin JM , McArdle CA , Steinhelper ME

C-type natriuretic peptide (CNP) is encoded by the Nppcgene and is abundant in the hypothalamus and anterior pituitary gonadotrophs. Nppc deletion leads to skeletal deformity, dwarfism, early death and female infertility. To investigate regulation of Nppcexpression and action in the hypothalamic-pituitary-gonadal axis, we investigated transcriptional regulation of the Nppc promoter in alphaT3-1 gonadotroph cells by transient transfection of reporter...

ea0014p30 | (1) | ECE2007

Cardiovascular risk factors (CVRF) as predictors of microalbuminuria (MA) in type 2 diabetes mellitus (T2DM) patients

del Cañizo-Gomez Francisco Javier , Moreira-Andres Maria Natividad

MA is a marker of greatly increased cardiovascular morbidity and mortality in T2DM patients.Objective: To perform a prospective study of normoalbuminuric T2DM patients, analysing the association between CVRF at baseline and the development of MA at follow-up.Materials and methods: The prospective observational study was performed at Montes de Barbanza public health center, a specialized secondary referral center, which provides ser...

ea0012oc11 | Placenta, bone and genetics | SFE2006

Effect of leptin on hepatic carbohydrate metabolism and insulin signalling proteins in fetal sheep

Forhead AJ , Lamb CA , Franko KL , Cripps RL , Ozanne S , Blache D , Fowden AL

Although leptin is important in the control of appetite and energy expenditure in adulthood, its actions before birth are unclear. This study investigated the effects of leptin on hepatic carbohydrate metabolism and insulin signalling in fetal sheep. Twelve sheep fetuses were chronically-catheterised at 115–120 d of gestation (term 145±2 d), and infused intravenously with saline (0.9% NaCl; n=6) or recombinant ovine leptin (0.5–1.0 mg/kg/d; Protein Labora...

ea0012oc22 | Pituitary, ovary and steroids | SFE2006

Coupling of cell cycle progression to GR cellular distribution

Matthews LC , Spiller DG , Rivers CA , Norman MR , White MRH , Ray DW

Glucocorticoids (Gcs) are important regulators of cellular homeostasis, with their effects mediated by the intracellular glucocorticoid receptor (GR). Once activated, the GR may initiate rapid effects within the cytoplasm, but also translocate to the nucleus to affect gene transcription. The subcellular localisation of the GR is therefore an important determinant in the cellular response to Gcs.To analyse subcellular trafficking of the GR, HeLa cells wer...

ea0011oc5 | Signal transduction OC1 Novartis Oncology Young Investigator Award | ECE2006

The overexpression Pit-1 pathway, switch on by RET, get into apoptosis fate

Cañibano Acebes CM , Vidal A , Borrello MG , Diéguez C , Alcarez CV

RET is a tyrosine-kinase receptor having a GPI-linked co-receptor or GFRα. Moreover, RET has four different ligands (GDNF, NTN, ART and PSP) with its respective co-receptor (GFRα-1,-2,-3 and 4). Pituitary cells are differentiated specialized secretory cells. Sommatotrophs are responsible for growth during infancy and puberty until achievement of the final adult height. Although genetic factors leading to somatotroph hypoplasia are well known, no much is known about t...

ea0011p626 | Neuroendocrinology and behaviour | ECE2006

The influence of a GH receptor antagonist (GHRA) on the relationship between GH and IGF-I in adults with severe growth hormone deficiency (AGHD)

Pokrajac A , Berg CA , Bidlingmaier M , Strasburger CJ , Shalet SM , Trainer PJ

Approximately 50% of patients with severe AGHD (defined by the international consensus criteria, peak GH <3 ng/ml) have a normal age- and gender-related IGF-I. It remains unclear whether in these individuals IGF-I is GH-dependent.We performed a double-blind, randomised, placebo-controlled, cross-over study on the effect of pegvisomant (20 mg daily for 14 days) on the relationship between GH and IGF-I in 3 age-, gender- and BMI-matched cohorts (Norms:...