Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.19.02 | Pituitary–Acromegaly | ECE2015

Assessment of bone quality, measured by trabecular bone score, in acromegaly

Malchiodi Elena , Sala Elisa , Verrua Elisa , Cairoli Elisa , Carosi Giulia , Ferrante Emanuele , Filopanti Marcello , Ulivieri Fabio Massimo , Eller-Vainicher Cristina , Chiodini Iacopo , Mantovani Giovanna , Spada Anna

Introduction: Acromegaly is characterised by chronic exposure to high GH and IGF1 levels that leads to increased bone turnover. Regardless of BMD value, acromegalic patients seem to have an increased vertebral fracture risk probably due to a reduction of bone quality. Trabecular bone score (TBS) is a new index used for assessing bone microarchitecture. In this study TBS was used for the first time to analyze bone quality in acromegaly.Methods: 16 new acr...

ea0037ep53 | Adrenal cortex | ECE2015

Beneficial effects of replacement therapy with modified-release hydrocortisone in patients with adrenal insufficiency

Morelli Valentina , Messina Erika , Mendola Marco , Cairoli Elisa , Ambrosi Bruno , Cannavo Salvatore , Chiodini Iacopo , Spada Anna

Introduction: The classical replacement therapy for hypoadrenalism may expose patients to non-physiologic glucocorticoids levels with negative metabolic consequences. Up to now, one study demonstrated that, as compared to the classical treatment, a modified-release hydrocortisone (MRH), improves weight, blood pressure, glycaemic control and QoL in a 3-month follow-up period. Few data are available on the long-term persistence of these benefits.Design/met...

ea0070aep134 | Bone and Calcium | ECE2020

Radiofrequency Echographic Multi Spectrometry (REMS) evaluation in patients with primary osteoporosis and primary hyperparathyroidism

Grassi Giorgia , Palmieri Serena , Cairoli Elisa , Chiodini Iacopo , Arosio Maura , Eller Vainicher Cristina

Background: Radiofrequency Echographic Multi Spectrometry (REMS) is a new ultrasound-based tool for bone mineral density (BMD) measurement, recently approved by FDA for the use in clinical routine to diagnose osteoporosis (OP) and to monitor bone changes. However, data on patients with secondary OP are not available. The aim of our study was to compare REMS and DXA ability in identifying clinical (cFX) and morphometric vertebral fractures (VFx) in patients with primary OP (pOP...

ea0073oc6.4 | Oral Communications 6: Calcium and Bone | ECE2021

Bisphosphonates after Denosumab withdrawal reduce the vertebral fractures incidence

Grassi Giorgia , Chiodini Iacopo , Palmieri Serena , Cairoli Elisa , Arosio Maura , Eller Vainicher Cristina

ObjectiveSeveral studies showed that patients discontinuing denosumab (Dmab) may experience bone loss and incident vertebral fractures (VFx) due to a rebound bone turnover increase, suggesting the need of anti-resorptive (i.e. bisphosphonate BPs) therapy to mitigate this occurrence. However, the morphometric VFx (morphoVFx) incidence after Dmab discontinuation is unknown and scarce data are available about the BPs effect on BMD changes and Fx risk in thi...

ea0037ep247 | Calcium and Vitamin D metabolism | ECE2015

Clinical and biochemical response to denosumab in a young adult patient with craniofacial fibrous dysplasia

Cairoli Elisa , Eller-Vainicher Cristina , Rossi Diego Sergio , Beltramini Giada Anna , Russillo Antonio , Mantovani Giovanna , Spada Anna , Chiodini Iacopo

We report on the clinical and biochemical outcomes in a 20-year-old male suffering from active craniofacial monostotic fibrous dysplasia (MFD) treated with the RANK-L inhibitor, Denosumab, following unsatisfactory responses to prior long-term bisphosphonates therapy. The patient had been treated over 9 years with pamidronate (cumulative dose of 81 mg), but experienced only mild reductions in pain scores. Following initiation of Denosumab 60 mg subcutaneously, bone pain and bon...

ea0056p195 | Bone ' Osteoporosis | ECE2018

Cystic fibrosis-related bone disease in young adults affected with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure

Cairoli Elisa , Eller-Vainicher Cristina , D'Adda Alice , Briganti Federica , Pappalettera Maria , Tarsia Paolo , Arosio Maura , Chiodini Iacopo

Background: Cystic fibrosis-related bone disease (CFBD) is an emerging complication of cystic fibrosis (CF), especially in CF-lung transplant candidates for end-stage disease.Objectives: The assessment of vitamin D levels, bone mineral density (BMD) and morphometric and clinical prevalent fragility fractures in a cohort of young adults affected with CF awaiting lung transplantation for end-stage respiratory failure.Methods: In 42 C...

ea0081p307 | Calcium and Bone | ECE2022

Impact of underlying disease on long-term skeletal outcome after lung transplantation

Grassi Giorgia , Chiodini Iacopo , Cairoli Elisa , Corinna Morlacchi Letizia , Rossetti Valeria , Rosso Lorenzo , Righi Ilaria , Nosotti Mario , Arosio Maura , Blasi Francesco , Eller Vainicher Cristina

Background: fragility fractures (FX) occur frequently after lung transplantation (TX), with a higher rate (15-20%) in the first two years, which decreases subsequently. Patients affected from cystic fibrosis (CF) seem to have a lower FX risk in the first two years after TX as compared with those affected with other lung diseases (nCF). The aim of our study is to evaluate and compare the long-term skeletal outcome in CF and nCF patients after TX.Methods: ...

ea0090p565 | Adrenal and Cardiovascular Endocrinology | ECE2023

The degree of cortisol secretion is associated with cardiometabolic complications in patients with nonfunctioning adrenal tumors

Favero Vittoria , Aresta Carmen , Parazzoli Chiara , Cairoli Elisa , Eller Vainicher Cristina , Palmieri Serena , Salcuni Antonio , Arosio Maura , Persani Luca , Scillitani Alfredo , Morelli Valentina , Chiodini Iacopo

Most adrenal incidentalomas are benign and can be divided into nonfunctioning adrenal tumors (NFAT) and tumors with mild autonomous cortisol secretion (MACS). Several studies suggest that MACS may result in an increased risk for mortality and cardiometabolic disease. The cardiometabolic risk in MACS is possibly related to the increased frequency of cardiovascular risk factors such as diabetes mellitus (DM) and hypertension (HT) induced by cortisol excess. This is confirmed by ...

ea0032p74 | Bone and Osteoporosis | ECE2013

Bone quality, as measured by trabecular bone score (TBS), in patients with primary hyperparathyroidism

Eller-Vainicher Cristina , Filopanti Marcello , Palmieri Serena , Ulivieri Fabio Massimo , Morelli Valentina , Zhukouskaya Volha V. , Cairoli Elisa , Pino Rosa , Naccarato Antonella , Verga Uberta , Scillitani Alfredo , Beck-Peccoz Paolo , Chiodini Iacopo

The fracture risk in primary hyperparathyroidism (PHPT) is partially independent of bone mineral density (BMD) and seems to depend on decreased bone quality, which is still reliably assessed only with invasive techniques. Trabecular bone score (TBS) is a grey-level texture measurement acquired during a dual X-ray absorptiometry (DXA) lumbar spine scan and it has been recently proposed as index of bone quality. This study is aimed to assess the role of TBS in predictin...

ea0099rc2.4 | Rapid Communications 2: Calcium and Bone | Part I | ECE2024

Primary hyperparathyroidism in children and adolescents: Clinical features and treatment outcomes from an Italian multicenter study

Cetani Filomena , Della Valentina Simone , Scillitani Alfredo , Dal Lago Anna , Pierotti Laura , Sardella Chiara , Madeo Bruno , Cairoli Elisa , Eller Vainicher Cristina , Procopio Massimo , Barale Marco , Palmieri Serena , Gianotti Laura , Castellano Elena , Lania Andrea , Pitea Marco , Lanzi Roberto , Maggiore Riccardo , Cipriani Cristiana , Pepe Jessica , Corbetta Sabrina

Primary hyperparathyroidism (PHPT) is rare in the pediatric population, with an estimated incidence of 0.5–5 cases per 100,000 person-years in children. Data regarding the clinical phenotype, the surgical outcomes are scarce. The objective of our study was to retrospectively analyze the phenotype of apparently sporadic PHPT in patients ≤21 years in major endocrinology reference centers in Italy. None of the patients had known familial syndromes. A total of 41 patien...