Searchable abstracts of presentations at key conferences in endocrinology

ea0035p341 | Diabetes (epidemiology, pathophysiology) | ECE2014

Exenatide protects pancreatic islets against brain death-induced inflammation and viability loss

Carlessi Rodrigo , Dias Ana Luiza , Bauer Andrea , Canani Luis Henrique , Leitao Cristiane , Crispim Daisy

Introduction: Pancreatic islet transplantation is an attractive approach to re-establish glycemic homeostasis in patients with brittle type 1 diabetes. However, islet damage along the isolation procedure limits the availability of viable islets for transplantation. The donor’s brain death (BD) is among the factors contributing for islet quality loss in this scenario. Exenatide, a glucagon-like peptide-1 (GLP1) analog, exerts anti-inflammatory effects leading to an increas...

ea0035p353 | Diabetes (epidemiology, pathophysiology) | ECE2014

Association between Asp299Gly and Thr399Ile polymorphisms in TLR4 gene and type 2 diabetes mellitus: Case-control study and meta-analysis

Assmann Tais , Lemos Natalia , Brondani Leticia , Carlessi Rodrigo , Canani Luis Henrique , Crispim Daisy

Introduction: Polymorphisms in genes that encode proteins of the innate immune system, such as the toll-like receptor 4 (TLR4), could affect the immune response as well as the prevalence of type 2 diabetes mellitus (T2DM). Activated TLR4 induces expression of a spectrum of proinflammatory cytokines, which have been implicated in insulin resistance. Some studies have reported associations of the TLR4 Asp299Gly and Thr399Ile polymorphisms with T2DM. However, ot...

ea0035p365 | Diabetes (epidemiology, pathophysiology) | ECE2014

UCP1, UCP2 and MnSOD expression in pancreas from brain-death subjects: A case-control study

Brondani Leticia , Boelter Gabriela , Carlessi Rodrigo , Rheinheimer Jakeline , Bauer Andrea Carla , Canani Luis Henrique , Crispim Daisy

Introduction: Long-term insulin independence after pancreatic islet transplantation depends on the engraftment of a large number of viable islets. However, the yield and quality of islets isolated from brain-death (BD) donors are negatively affected by upregulation of proinflammatory cytokines and by hypoxia and oxidative stress that occurs during the BD status. Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner mitochondrial membrane and are associ...

ea0049gp94 | Diabetes therapy & complications 1 | ECE2017

The A allele of the -866G/A polymorphism in UCP2 gene decreases high glucose-induced UCP2 expression in HUVECs

Assmann Tais , Crispim Daisy , Rodrigues Michelle , Silva Liana , Boucas Ana Paula , Carlessi Rodrigo , Brondani Leticia , Canani Luis Henrique , Souza Bianca

Uncoupling protein 2 (UCP2) is a mitochondrial protein located in the mitochondrial inner membrane, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing reactive oxygen species (ROS) formation by mitochondrial respiratory chain. ROS overproduction is related to diabetic retinopathy (DR), a chronic complication of diabetes mellitus (DM). Recently, our group reported that the -866A/55Val/Ins haplot...