Searchable abstracts of presentations at key conferences in endocrinology

ea0056p473 | Diabetes complications | ECE2018

The effect of glutathione S-transferase M1 and T1 polymorphisms on ascorbic acid plasma levels in diabetic patients

Valente Ana , Bicho Manuel , Carolina Santos Ana , Matos Andreia , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...

ea0073aep876 | Late Breaking | ECE2021

Influence of bitter taste gene TAS2R38 on endocrinometabolic and anthropometric parameters in a sample with thyroid disease

Mendes Costa Marta , Carolina Santos Ana , Ferreira Joana , Mário Rui Mascarenhas , Bicho Manuel , Paula Barbosa Ana , Alda Pereira da Silva

Background and objectivesTAS2R38 is a bitter taste gene that can influence food consumption depending on its single nucleotide polymorphisms (SNPs) leading to aminoacid substitutions in the receptor protein P49A (proline/alanine), A262V (alanine/valine) e V296I (valine/isoleucine). Subjects with at least one PAV (proline-alanine-valine) copy are bitter tasters, while AVI homozygotes are non-tasters. Other variants have intermediate bitter tasting: AAV&#6...