Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep461 | Thyroid | ECE2020

Immunoassay interference on thyroid functions tests during treatment with Nivolumab

Maria Paragliola Rosa , Corsello Andrea , Papi Giampaolo , Melfa Eleonora , Urbani Andrea , Pontecorvi Alfredo , Carrozza Cinzia , Maria Corsello Salvatore

Background: Immune checkpoint inhibitors (ICI), anticancer therapy blocking specific molecules expressed in tumor microenvironment, are associated to several endocrine side effects. In particular, the use of PD-1/PD-L1 inhibitors is related to a higher incidence of thyroid dysfunction. The most frequent form of thyrotoxicosis is a destructive thyroiditis, which can evolve into hypothyroidism.Patient findings:We report the case of an 85 years-old patient,...

ea0075t08 | Thyroid | EYES2021

Antibody Interference in Thyroid Assays: a case report

Mura Chiara , Menotti Sara , Zelano Lorenzo , Novizio Roberto , Rossi Laura , Carrozza Cinzia , Locantore Pietro , Maria Corsello Salvatore

Background: Endogenous and exogenous factors may cause biochemical interferences with thyroid function immunoassays. Interference can be caused by many mechanisms including heterophilic antibodies, drugs and rheumatoid factors. Moreover, assay-specific interference has been described, such as antithyroid hormone antibodies resulting in falsely elevated or lowered concentrations depending on the assay.Case Presentation: We describe a case of a 38-years ol...