Searchable abstracts of presentations at key conferences in endocrinology

ea0029p871 | Endocrine tumours and neoplasia | ICEECE2012

Leydig cell tumor of ovary: a rare case of virilization

Souto S. , Vieira-Baptista P. , Barreto F. , Carvalho-Braga D. , Carvalho D.

Introduction: Leydig cell tumors are a type of steroid cell tumor, account for 0.1% of all ovarian tumors. The clinical presentation is usually a hyperandrogenic state with signs of virilisation. The tumor has a benign behavior, with an excellent prognosis and reversion of symptoms after surgical treatment.Case report: Woman, 81 years-old, nulliparus, with clinic hyperandrogenism and vaginal bleeding during the last year. She had history of dementia synd...

ea0026p642 | Clinical case reports | ECE2011

Giant invasive macroprolactinoma

Alves M , Neves C , Pereira J , Bastos M Ayres , Bernardes I , Carvalho-Braga D , Carvalho D

Background: Apart from signs of hyperprolactinaemia, patients with macroadenomas with extrasellar extension generally seek medical attention due to mass effect. Macroprolactinomas, particularly in men, may occasionally exhibit a very aggressive clinical course.Case report: Male 37 years old that went to a Neurology consultation complaining of progressively more frequent self-limiting episodes of restraint, silence and time and space disorientation in the...

ea0026p643 | Clinical case reports | ECE2011

Bexarotene associated dyslipidaemia and central hypothyroidism in a patient with Sézary syndrome

Alves M , Neves C , Azevedo F , Correia O , Carvalho-Braga D , Carvalho D

Background: Sézary syndrome (SS) is a more aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL). Bexarotene (Targretin) is a synthetic rexinoid analogue designed for the treatment of advanced stages of cutaneous manifestations of CTLC. Bexarotene selectively suppresses thyrotropin secretion and up to 40% of patients develop reversible idiopatic central hypothyroidism. Severe mixed dyslipidemia may be present in up to 70%.Case report: Seve...

ea0026p610 | Clinical case reports | ECE2011

Cholestatic jaundice methimazole-induced or secondary to heart failure?

Souto S B , Rodrigues P , Belo S , Nogueira C , Magalhaes A , Castedo J L , Carvalho-Braga D , Carvalho D

Methimazole-induced cholestatic jaundice is a rare adverse effect, dose-dependent, occurring within the first 3 months of use, usually reversible within 3 months after discontinuing drug therapy.Case report: Woman, 64 years, history of hyperthiroidism since August 2009, under therapy with methimazole 5 mg/day. The patient was referred to endocrinology department in March 2010, with history of heart failure, atrial fibrillation, type 2 diabetes mellitus, ...

ea0029p1489 | Pituitary Clinical | ICEECE2012

Influence of the family environment during the early years in life in the vulnerability to the development of pituitary adenomas

Afonso A , Carvalho D

Introduction: Prolactinomas are the most common pituitary adenomas. Several authors hypothesized that there is an association between the development of pituitary adenomas and psychologically significant experiences, especially traumatic ones. This is particularly well-established for Cushing’s disease. When it comes to prolactinomas, it was suggested that prolactin acts as an alternative to cortisol in the response to stress, especially in patients who present with passi...

ea0029p1504 | Pituitary Clinical | ICEECE2012

Hyperprolactinemia: prolactinoma or pregnancy?

Belo S , Magalhaes A , Carvalho D

Introduction: High prolactin levels may have several etiologies including the presence of a prolactin producing pituitary adenoma or the treatment with drugs of different classes. Certain physiological states, from which pregnancy stands out, are also characterized by elevated levels of prolactin.Case: Woman, 28 years old, with no relevant medical history or chronic medication apart from oral contraceptives, begins with amenorrhea in May 2010, without ga...

ea0026p654 | Clinical case reports | ECE2011

Type II polyglandular syndrome: a case report

Belo S , Magalhaes A , Carvalho D

Introduction: The combination of two or more, autoimmune, endocrine dysfunctions defines the presence of polyglandular syndromes.Case report: Female patient, 43 years old, history of type 1 diabetes for 23 years and autoimmune hypothyroidism for 7 years, with no other relevant clinical history and without family history of autoimmune endocrinopathies. She was under therapy with insulin and levothyroxine. She came into the Endocrinology Department in May ...

ea0029p115 | Adrenal medulla | ICEECE2012

Pheochromocytomas: a single centre experience

Belo S. , Magalhaes A. , Nogueira C. , Carvalho D.

Introduction: Catecholamine-secreting tumors (pheochromocytomas and paragangliomas) are rare intra and extra-adrenal neoplasms, probably occurring in less than 0.2% of patients with hypertension. Serious morbidity and mortality rates are associated with these tumors which are related to the effects of catecholamines on various organs, especially those of the cardiovascular system.Methods: We reviewed the cases of pheochromocytomas and paragangliomas that...

ea0026p625 | Clinical case reports | ECE2011

Testicular microlithisis: how worried should we be?

Matos M J , Freitas P , Carvalho D

Introduction: Gynecomastia is a relatively common reason for consultation, with a high prevalence in the neonatal period, puberty and with aging. The diagnostic approach should be more thorough in normal-weight individuals with recent onset of gynecomastia, rapid growth of breast tissue, or in the setting of a large painful breast. Besides the evaluation of liver function, testosterone, estradiol, LH and β-hCG, testicular ultrasound evaluation is important to exclude test...

ea0041ep1104 | Thyroid cancer | ECE2016

Thyroid cancer in hyperthyroid patients treated by surgery

Domingues A L , Rodrigues E , Saavedra A , Matos Lima L , Carvalho D

Introduction: The association of hyperthyroidism and thyroid cancer (TC) is controversial with prevalences in the literature varying from 1.6 to 32.8%. The aim of this work was to evaluate the prevalence of TC in hyperthyroid patients submitted to surgery and to find differences between the tumors according to the type of hyperthyroidism.Material and methods: retrospective study to evaluate clinical and histopathological data of all hyperthyroid patients...