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Endocrine Abstracts

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ea0044oc6.2 | Pregnancy and Reproductive Health | SFEBES2016

The thyroidal response to hCG stimulation is impaired in women with subclinical hypothyroidism and is influenced by BMI, fetal sex and parity

Korevaar Tim , Chaker Layal , Visser Theo , Peeters Robin

Introduction: Although hCG is an important determinant of gestational thyroid function, it is unknown to what extent hCG is a risk factor for thyroid disease and we also lack knowledge on which characteristics influence the thyroidal response to hCG stimulation.Methods: hCG, TSH, FT4 and TPOAbs were measured in 5435 pregnant women (<18 weeks) in a prospective cohort. Subclinical disease entities were defined according to P2.5-P97.5 in TPOAb negative ...
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ea0037gp.27.06 | Thyroid – hyperthyroidism and treatment | ECE2015

hCG levels are essential for the correct interpretation of gestational TSH levels: the clinical risk assessment of premature delivery

Korevaar Tim , Medici Marco , Chaker Layal , Tiemeier Henning , Visser Theo , Peeters Robin

Context: High maternal TSH and/or low FT4 during pregnancy is associated with an increased risk of premature delivery. hCG is the main determinant of thyroid function changes during pregnancy but has a versatile pattern with high inter and intra-individual variability. We hypothesised that the correct interpretation of thyroid function tests and its use in the risk assessment of premature delivery during pregnancy depend on hCG levels.Design, ...
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ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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