Searchable abstracts of presentations at key conferences in endocrinology

ea0081p384 | Endocrine-Related Cancer | ECE2022

Appendiceal neuroendocrine neoplasms diagnosed during pregnancy-case series and review of the literature

Twito Orit , Amit Akirov , Chava Rosenblum Rachel , Herzberg Dana , Oleinikov Kira , Pnina Rotman-Pikielny , Glasberg Simona

Introduction: Although appendicitis occurs in approximately 1:1000 pregnancies, appendiceal neuroendocrine neoplasm (ANEN) diagnosis during pregnancy is very rare. Data on presentation, treatment and prognosis is scarce.Aim: To describe ANEN cases diagnosed during pregnancy.Materials and Methods: A retrospective appraisal of 7 consecutive ANEN patients diagnosed during pregnancy from four Israeli tertiary medical centers and compar...

ea0063p107 | Calcium and Bone 1 | ECE2019

Pseudohypoparathyroidism- a tale of hypo- and hypercalcemia with a genetic solution

Chava Rosenblum Rachel , Einbinder Yael , Twito Orit , Mantovani Giovanna , Marta Elli Francesca , Rotman-Pikielny Pnina

Introduction: Pseudohypoparathyroidism (PHP) is a rare genetic disease characterized by renal resistance to parathyroid hormone (PTH), presenting with hypocalcemia, hyperphosphatemia and elevated PTH levels. We describe a PHP patient who presented with clinically significant hypercalcemia.Case description: A 46-year-old woman with a prior history of hypocalcemia presented to the emergency department with new-onset hypercalcemia, renal failure and anemia....

ea0070ep71 | Bone and Calcium | ECE2020

Efficacy and safety of pamidronate in the treatment of parathyroid hormone-dependent hypercalcemia in hospitalized patients

Chava Rosenblum Rachel , Twito Orit , Barzilay-Yoseph Liat , Ramaty Erez , Klein Noa , Rotman-Pikielny Pnina

Background: Bisphosphonates are effective in malignancy-related hypercalcemia and have been beneficial in parathyroid-hormone (PTH)-dependent hypercalcemia in small randomized-controlled trials. However, data regarding efficacy and safety in PTH-dependent hypercalcemia is limited, and pamidronate is not indicated for this condition.Objective: To evaluate efficacy and safety of pamidronate in moderate-severe PTH-dependent hypercalcemia. Control groups wer...

ea0099oc10.6 | Oral Communications 10: Calcium and Bone | Part II | ECE2024

Efficacy of a computerized therapeutic decision-making algorithm in a Fracture Liaison Service targeting hip fracture patients

Chava Rosenblum Rachel , Kogan Arthur , Herzberg Dana , Najjar Maysara , Hershkovich Oded , Twito Orit , Lotan Raphael

Background: Osteoporotic fracture risk is doubled in patients with recent fracture; however, post-fracture treatment rates remain dismal. Fracture Liaison Services (FLS) aim to close the secondary prevention ‘gap’ and reduce fracture risk. This study evaluates the efficacy of a computer algorithm-supported, Nurse Practitioner-managed FLS developed in Wolfson Medical Center (WMC).Methods: A computerized decision-making algorithm was developed us...

ea0081oc6.4 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Clinical correlates of a large Israeli cohort of Cys 618 Arg RET mutation

Chava Rosenblum Rachel , Hirsch Dania , Glasberg Simona , Benbassat Carlos , Yoel Uri , Ishay Avraham , Lamprecht Sagit Zolotov , Bachar Gideon , Banne Ehud , Twito Orit

Introduction: A syndrome of MEN2A and Hirschsprung’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...