Endocrine Abstracts

Platinum nanoparticles have shown to have a remarkable antioxidant activity. Growing evidence between oxidative stress and bone loss suggests that platinum nanoparticle could protect bone loss via modulating oxidative stress. Intragastrical administration of platinum nanoparticle reduced ovariectomy (OVX)-induced bone loss with lowered level of in vivo bone resorption. Platinum nanoparticle inhibited osteoclast (OC) formation via an impaired receptor activator of nuclea...

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includ...

Objective: Insulin resistance is a core feature of polycystic ovary syndrome (PCOS), thus, it may be the common link between PCOS and type 2 diabetes (T2DM).Although the etiology of PCOS has not been elucidated, a number of studies have suggested that genetic factors may play important roles in its etiology and pathogenesis. If PCOS and T2DM share a common genetic background, genetic variants determining the risk of T2DM may also be associated with PCOS....

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...

The transcription factors Runx2 and osterix (Osx), which are known as downstream genes in BMP2 pathway, are essential for osteoblast differentiation and bone formation. Runx2 expression is normal in Osx null mice, but Osx is not expressed in Runx2 null mice, indicating that Osx acts as a downstream of Runx2. Here, we questioned whether or not all bones could be formed by BMP2–Runx2–Osx pathway or unknown their own gene axis. To answer this question, we first analyzed...