Searchable abstracts of presentations at key conferences in endocrinology

ea0014p157 | (1) | ECE2007

Prevalence of autonomous cortisol and aldosterone secretion in patients with a single benign cortical adrenal adenoma after modification of the diagnostic tests

Piaditis George , Kaltsas Gregory , Kounadi Theodora , Markou Athina , Mazarakis Nikos , Gouli Aggeliki , Makras Polyzois , Papadogias Dimitrios , Dimitriou Kostantina , Stathopoulou Alexandra , Kossyvakis Kostantinos , Despoina Ragkou , Kyriakos Vamvakidis , Zografos George , Kontogiorgos George , Chrousos George

Background: The normal cut-offs of screening and diagnostic tests for autonomous aldosterone (AAS) and cortisol (ACS) secretion are poorly defined, mainly due to the presence of adrenal adenomas among those who have served as controls and the stimulating effect of ACTH on aldosterone secretion.Methods: We investigated cortisol and aldosterone secretion in 151 patients with benign cortical adrenal adenomas (BCAA) and in 119 healthy controls with a normal ...

ea0016gh1 | The Geoffrey Harris Prize Lecture | ECE2008

From Geoffrey Harris’s hypothalamic principle to a unified theory of stress and stress system disorders

Chrousos George P

The existence of the principle of hypothalamic hypophysiotropic factors, predicted so prophetically by G W Harris in the 1940’s, has been confirmed by irrefutable evidence. This principle is central to the survival of complex organisms as both individuals and species. Life exists through maintenance of a complex dynamic equilibrium, or homeostasis, that is constantly challenged by intrinsic or extrinsic adverse forces, or stressors. Thus, stress is defined as a state of t...

ea0016gh1biog | The Geoffrey Harris Prize Lecture | ECE2008

Geoffrey Harris Prize Lecture

Chrousos George P

This prestigious prize is intended for established workers in the field of basic or clinical neuroendocrinology, and is generously support by Ipsen. This year's recipient is Professor George P Chrousos. The prize will be presented as part of the ECE 2008 opening ceremony where Professor Chrousos will deliver his lecture. Professor Chrousos will also give two other lectures at future ESE scientific meetings. Further information can be found at <a href="http://www...

ea0081p733 | Thyroid | ECE2022

Increased incidence of primary hyperparathyroidism in patients with papillary thyroid cancer. Just a coincidence or a new syndrome. 

Papadopoulou-Marketou Nektaria , Chrousos George , Tsiamyrtzis Panagiotis , Karvounis Evaggelos

Presence of primary hyperparathyroidism (PHPT) in patients with thyroid disease has been previously reported. However, co-existence of PTHPT and papillary thyroid cancer (PTC) has been reported very rarely, mainly in the form of isolated case reports. Since the pathophysiological mechanisms of the two diseases are theoretically quite different, no causal relation between these diseases has been inferred. The aim of this study was to investigate the presence of PHTP in individu...

ea0037ep286 | Calcium and Vitamin D metabolism | ECE2015

Thalassemia-induced osteoporosis and bisphosphonate treatment: a systematic review and meta-analysis

Tsartsalis Athanasios , Lambrou George , Savvidis Christos , Chrousos George , Kattamis Antonis

Introduction: Osteopenia and osteoporosis develop with aging in thalassemia patients despite clinical treatment therapy has improved. Bisphosphonates, which are potent inhibitors of osteoclastic bone resorption, have been recently used to correct the bone abnormality in thalassemia with encouraging results. Bisphosphonates are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used t...

ea0013p267 | Steroids | SFEBES2007

Identification of a novel, point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor-α (hGRα) gene and molecular characterization of the mutant receptor hGRαF737L

Charmandari Evangelia , Kino Tomoshige , Ichijo Takamasa , Zachman Keith , Chrousos George

Background: Generalized glucocorticoid resistance is a rare condition characterized by partial, end-organ insensitivity to glucocorticoids, compensatory elevations in ACTH and cortisol secretion, and increased production of adrenal steroids with androgenic and/or mineralocorticoid activity. We identified a new case of glucocorticoid resistance caused by a novel, heterozygous point mutation at nucleotide position 2209 (T → C) of the hGRα gene, resulting in phenylalan...

ea0063p416 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

High prevalence of autonomous aldosterone secretion in patients with type 2 Diabetes Mellitus and arterial hypertension. The effect of SGLT2 inhibitors on renin-angiotensin-aldosterone system

Tyfoxylou Ernestini , Papanastasiou Labrini , Piaditis George , Voulgaris Nikolaos , Chrousos George , Kounadi Theodora

Introduction: The causes of arterial hypertension in diabetic and non-diabetic hypertensive patients are still not clear. However, in recent studies in non-diabetic hypertensive patients (NDHP) we observed dysregulation of aldosterone (ALD) secretion either in the form of autonomous secretion or as hyperesponse to stress. To the best of our knowledge, a similar study in hypertensive patients with type 2 Diabetes Mellitus (DHP) has not been conducted yet....

ea0049gp46 | Bone & Calcium Homeostasis 2 | ECE2017

Vitamin D correction elevates apolipoprotein levels in a sex-specific manner

Al-Daghri Nasser , Garbis Spiros , Chrousos George , Sabico Shaun , Aljohani Naji , Al-Saleh Yousef

Numerous studies have identified several extra-skeletal health outcomes to be associated with vitamin D deficiency, yet a definitive causal link is yet to be discovered. Our recent 3D LC-nESI-FTMS proteomic analysis among normal and overweight but apparently healthy adult Saudis identified apolipoproteins, a known independent cardiovascular risk factor, as one of the serological molecular signatures that modulate vitamin D levels. The present interventional study aims to compa...

ea0041gp170 | Receptors &amp; Signalling | ECE2016

Altered exression of circadian clock genes in polyglandular autoimmune syndrome type III

Angelousi Anna , Nasiri-Ansari Narjes , Spilioti Eliana , Kalotychou Vasiliki , Chrousos George , Kaltsas Gregory , Kassi Eva

Introduction: CLOCK system is a highly conserved, ubiquitous molecular ‘clock’ which creates internal circadian rhythmicity under the influence of light/dark information. CLOCK system is regulated by the coordinated activation/inactivation of several transcription factors, including the CLOCK, the BMAL1 and other essential regulators, such as the Pers, Crys and RORs. The present study aimed to evaluate the circadian rhythm of clock-related genes expressed in patients...

ea0037ep616 | Obesity and cardiovascular endocrinology | ECE2015

A low glycaemic index, low glycaemic load snack based on stevia and fortified with vitamin D, improves metabolic/hormonal profile, and compliance in normal subjects and prediabetics; results from a 4 months, controlled trial

Livadas Sarantis , Dastamani Antonia , Stefanaki Charikleia , Mantzou Emily , Painesi Areti , Papanikolaou Eleni , Chrousos George

Introduction: Half of subjects following a low-calorie dietary program cannot tolerate its nutritional restrictions and abandon it. A realistic approach to overcome this obstacle is the addition of low glycaemic index (GI), low glycaemic load (GL) snacks in their nutrition. Stevia, a potent, low calorie natural sweetener exerts anti-hyperglycaemic and insulinotropic activities. Furthermore, Vitamin D deficiency may affect diabetes development in the long run.<p class="abst...