Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep405 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Aldo-keto reductase (AKR) 1C1 – a potential driver of cell cycle progression in hepatocellular carcinoma

da Conceição Ismael , Nikolaou Nikolaos , Arvaniti Anastasia , Gathercole Laura , Hodson Leanne , Tomlinson Jeremy

The health burden associated with non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, continues to escalate. Not only is NAFLD associated with significant liver-specific and cardiovascular morbidity and mortality, but patients are at risk of the development of hepatocellular carcinoma (HCC); a malignancy where the incidence continues to rise and there are very limited therapeutic strategies.Aldo-keto reductase ...

ea0073aep465 | Pituitary and Neuroendocrinology | ECE2021

Hypothalamic-pituitary-adrenal axis activity in patients with primary polydipsia and healthy volunteers

Kuehne Jill , Sailer Clara , Ismael da Conceição , Refardt Julie , Christ-Crain Mirjam , Winzeler Bettina

BackgroundThe pathophysiology of primary polydipsia, a disorder with increased fluid intake, is poorly understood. A dysregulation in the hypothalamic-pituitary-adrenal axis (HPA) is speculated and arises mainly from research in patients witch a schizophrenia spectrum disorder but data is contradictory. The aim of this study was to investigate markers of HPA axis activity in patients with primary polydipsia compared to healthy controls.<p class="abst...

ea0070aep620 | Pituitary and Neuroendocrinology | ECE2020

Growth hormone deficiency in childhood acute lymphoblastic leukemia survivors – should systematic stimulation test be performed in all irradiated children?

Damasio Ines , Cavaco Daniela , Maciel Joana , Dias Daniela , Donato Sara , Pinheiro Sara , Figueiredo Ana , Simões-Pereira Joana , Pereira Conceiçao

Introduction: The combination of chemotherapy with prophylatic cranial radiotherapy (C-RT) allowed the improvement of survival rates of pediatric acute lymphoblastic leukemia (ALL) survivors while putting them at risk of develeping long-term endocrine deficiencies, like growth hormone deficiency (GHD).Current evidence suggests that the prevalence of GHD in children treated with radiation doses ≥ 30–50 Gy for non-pituitary brain tumors is...