Endocrine Abstracts

Background: Type 1 diabetes mellitus (T1DM) management profoundly changed across years, with increasing emphasis on stringent glycaemic control. While it is well demonstrated that the progressive improvement of glycaemic control allows a tighter command of diabetes-related complications, the positive implications thereof on reproductive functions are still unclear. Indeed, it is well known that oligomenorrhea and amenorrhea are more frequently detected in young women with T1DM...

Background: Patients with CHH and KS have eunuchoid body proportions of the skeleton compared to normal male subjects, characterized by tall stature, and reduced upper-to-lower segment ratio (U/l). Vice versa, steroids exposure deeply differs between CHH and KS at puberty, with both testosterone and estradiol being very low only in CHH. At present, body skeletal proportions comparison between CHH and KS is not available.Aim: To compare anthropom...

Introduction: Hypothyroidism treatment is classically based on levothyroxine (LT4). However, 10% of hypothyroid patients treated with LT4 complain of hypothyroidism symptoms, despite normal thyroid stimulating hormone (TSH) serum levels. This ”peripheral hypothyroidism” has been linked to decreased availability of free triiodothyronine (fT3), likely related to single nucleotide polymorphisms (SNP) in deiodinase genes (DIO), reducing enzymatic activity. Since...

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...