Searchable abstracts of presentations at key conferences in endocrinology

ea0081p83 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Menstrual cycle abnormalities as distinctive sign of type 1 diabetes mellitus: results from a meta-analysis

Corleto Rossella , Greco Carla , Cacciani Marta , Spaggiari Giorgia , Simoni Manuela , Santi Daniele

Background: Type 1 diabetes mellitus (T1DM) management profoundly changed across years, with increasing emphasis on stringent glycaemic control. While it is well demonstrated that the progressive improvement of glycaemic control allows a tighter command of diabetes-related complications, the positive implications thereof on reproductive functions are still unclear. Indeed, it is well known that oligomenorrhea and amenorrhea are more frequently detected in young women with T1DM...

ea0081ep851 | Reproductive and Developmental Endocrinology | ECE2022

Eunuchoid skeletal proportions in male hypogonadism: a comparative analysis of anthropometric measures between men with congenital hypogonadotropic hypogonadism (CHH) and Klinefelter Syndrome (KS)

De Vincentis Sara , Corleto Rossella , Bellelli Alessio , Zirilli Lucia , Santamaria Emanuele , Granata Antonio , Rochira Vincenzo

Background: Patients with CHH and KS have eunuchoid body proportions of the skeleton compared to normal male subjects, characterized by tall stature, and reduced upper-to-lower segment ratio (U/l). Vice versa, steroids exposure deeply differs between CHH and KS at puberty, with both testosterone and estradiol being very low only in CHH. At present, body skeletal proportions comparison between CHH and KS is not available.Aim: To compare anthropom...

ea0081oc11.1 | Oral Communications 11: Thyroid 2 | ECE2022

Thr92Ala polymorphism of the type 2 deiodinase (DIO2) is associated with higher risk of iatrogenic thyrotoxicosis in thyroidectomized subjects treated with levothyroxine and liothyronine

Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Simoni Manuela , Rochira Vincenzo , Santi Daniele , Brigante Giulia

Introduction: Hypothyroidism treatment is classically based on levothyroxine (LT4). However, 10% of hypothyroid patients treated with LT4 complain of hypothyroidism symptoms, despite normal thyroid stimulating hormone (TSH) serum levels. This ”peripheral hypothyroidism” has been linked to decreased availability of free triiodothyronine (fT3), likely related to single nucleotide polymorphisms (SNP) in deiodinase genes (DIO), reducing enzymatic activity. Since...

ea0090oc2.1 | Oral Communications 2: Thyroid | ECE2023

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

Brigante Giulia , Santi Daniele , Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Roy Neena , Casarini Livio , Trenti Tommaso , Varani Manuela , De Santis Maria Cristina , Roli Laura , Rochira Vincenzo , Simoni Manuela

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...