Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1238 | Clinical Cases–Pituitary/Adrenal | ECE2015

Adrenal crisis due to steroid withdrawal

Salehmohamed Muhammad Ridhwaan , Cuesta Martin , Thompson Chris

Introduction: Hen corticosteroids are utilised for their anti-inflammatory properties, adrenocortical atrophy may result. Abrupt steroid withdrawal or intercurrent illness can precipitate acute adrenal crisis. We report two cases of adrenal crisis which resulted from withdrawal of immunosuppressive steroid therapy.Case report: i) A 74-year-old gentleman was admitted with hypotension (BP 80/40), severe hyponatremia (Na:118 mmol/l) and acute renal failure ...

ea0037ep738 | Pituitary: clinical | ECE2015

Obstructive sleep apnoea is common in patients who have had surgery for non-functioning pituitary adenomas; preliminary data

Hernandez Martin Cuesta , Crowley Rachel , Costello Richard , Thompson Christopher

Introduction: Some patients complain of excessive daytime somnolence following pituitary surgery.Aim: To investigate the presence of obstructive sleep apnoea (OSA) following surgery for non functioning pituitary adenomas (NFPA).Design and methods: We assessed the prevalence of OSA in 16 routinely selected patients following surgery for NFPA and 13 obese controls attending a tertiary referral centre, by means of the Epworth Sleepine...

ea0059p141 | Neuroendocrinology and pituitary | SFEBES2018

Active management of severe hyponatraemia by endocrinologists is associated with lower mortality

Garrahy Aoife , Hannon Anne Marie , Cuesta Martin , Murphy Bryan , Tormey William , Sherlock Mark , Thompson Chris

Severe hyponatraemia (SHN, <120 mmol/l) is reported to be associated with mortality as high as 50%; although there are several international guidelines for management of SHN, there are few data on the impact of treatment. We have longitudinally audited our treatment outcomes of SHN. We present the results of three audit periods, of six months each, from 2005, 2010 and 2015. The three periods represented; 2005, prior to hospital policy for SHN, 2010, audit of impact of poli...

ea0037gp.17.07 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Heterogenous patterns of recovery from adipsic diabetes insipidus in adult patients

Hernandez Martin Cuesta , Dineen Rosemary , Gupta Saket , Salehmohamed Ridhwaan , Thompson Christopher

Introduction: The natural history of adipsic diabetes insipidus (ADI) is not completely understood. Isolated case reports suggest occasional recovery of adipsia. We present the follow up of a cohort of 12 patients with ADI.Setting: National pituitary unit with interest in diabetes insipidus.Methods: ADI was identified by demonstrating absent thirst and AVP responses to hypertonic saline infusion. Results 12 patients with ADI were i...

ea0037ep84 | Adrenal cortex | ECE2015

Awareness of adrenal crisis prevention in long-term steroid users

Salehmohamed Muhammad Ridhwaan , Griffin Mark , Branigan Tom , Cuesta Martin , Thompson Chris

Background: Patients taking corticosteroids for immune suppression are vulnerable to adrenal crisis during intercurrent illness or if steroids are stopped abruptly. Although patients on glucocorticoids for adrenal failure are routinely provided with sick day rules, we wished to ascertain whether patients on immunosuppressive steroids are appropriately counselled.Aim: This study sets out to compare patient awareness of steroid sick day rules in endocrine ...

ea0037ep703 | Pituitary: basic and neuroendocrinology | ECE2015

Mortality in SIADH is similar to that in non-SIADH hyponatraemia; preliminary data

Thompson Christopher J , Slattery David , Gupta Saket , Tormey William , Hernandez Martin Cuesta

Introduction: Excess mortality due to hyponatraemia is well documented but it is not clear whether the mortality associated with SIADH is different to that associated with non-SIADH hyponatraemia (NSH).Methods/design: Prospective evaluation of all patients admitted with or developing hyponatraemia in a tertiary hospital (pNa <130 mmol/l) in January 2015. Diagnosis of SIADH was based on standard clinical and biochemical criteria (pNa, spot urine sodiu...

ea0056p627 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Cross-hormone treatment: review of cardiovascular risk factors and bone mineral density in 25 transsexual subjects followed in a tertiary hospital

Azkutia Ane , Herraiz Lorea , Jimenez Ines , Barrio Elvira , Ramos Elvira , Cuesta Martin , Diaz Angel

Introduction and objectives: Transsexuality refers to discrepancy between the assigned sex/gender at birth and the one that the subject identifies with. The use of the cross hormone treatment as sex/gender change method implies the necessity of monitorize the hormone levels and potential treatment risks. Our study tries to evaluate the relationship between the hormone changes and the changes in the cardiovascular risk factors and the bone mineral density.<p class="abstext"...

ea0063p8 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Metabolic and cardiovascular profile of 143 adrenal incidentalomas

Araujo-Castro Marta , Nunez Miguel Sampedro , Ramirez Paola Parra , Lazaro Cristina Robles , Hernandez Martin Cuesta , Marazuela Monica

Objective: To study the differences in the metabolic profile of patients with non-functioning adrenal adenomas (NFA) and autonomous cortisol secretion (ACS).Methods: 143 patients diagnosed of adrenal incidentaloma (AI) between 2010 and 2018 were retrospectively analyzed. AI was defined as an adrenal mass≥1 cm, accidentally discovered by radiologic examination. ACS was confirmed by serum cortisol post-dexamethasone suppression test (Nugent)≥3 ...

ea0041ep877 | Pituitary - Clinical | ECE2016

“The incidence of central adrenal insufficiency in euvolaemic hyponatraemia. Results of a large prospective study”

Cuesta Martin , Slattery David , Garrahy Aoife , Hannon Anne Marie , Tatro Elizabeth , Gupta Saket , Sherlock Mark , Tormey William , Thompson Christopher J

Context: The syndrome of inappropriate antidiuresis(SIAD) is the commonest cause of hyponatraemia. Data on the aetiology of SIAD is mainly derived from retrospective studies, often with poor ascertainment of minimum criteria for correct diagnosis. Although central adrenal insufficiency(CAI) is known to cause euvolaemic hyponatraemia, the incidence of undiagnosed CAI in SIAD is unknown.Objective: To establish the incidence of CAI in SIAD.<p class="abs...

ea0059p135 | Neuroendocrinology and pituitary | SFEBES2018

Bolus 3% saline restores cognitive function more rapidly than traditional slow intravenous infusion of 3% saline in the emergency treatment of SIAD, with symptoms of cerebral irritation

Garrahy Aoife , Dineen Rosemary , Hannon Anne Marie , Zia-ul-Hussnain HM , Cuesta Martin , Sherlock Mark , Thompson Chris

Acute hyponatraemia is a medical emergency with high mortality. Recent expert guidelines advocate treatment with intravenous boluses of 3% saline with the aim to reduce cerebral oedema more rapidly than traditional slow intravenous infusion, but there is a poor evidence base for this policy change. We retrospectively audited treatment of symptomatic hyponatraemia due to SIAD (n=57, age 22–76 year), comparing low dose (20 ml/h) and bolus infusion of 3% saline. Bol...