Searchable abstracts of presentations at key conferences in endocrinology

ea0022p781 | Thyroid | ECE2010

Coagulation disorders in hypothyroidism: effects of thyroid hormones deficiency and/or of TSH?

Yango John , Alexopoulou Orsalia , Eeckoudt Stephane , Hermans Cedric , Daumerie Chantal

Various haemostatic abnormalities have been associated with thyroid dysfunction, especially with hypothyroidism. The underlying mechanisms are not well established.The aim of the study was to evaluate the primary and secondary haemostasis in patients with severe hypothyroidism, to assess the role of thyroid hormone deficiency and to determine whether increased serum TSH level despite normal free thyroid hormone concentrations could influence the coagulat...

ea0084ps2-07-66 | Graves’ Disease 1 | ETA2022

Influence of thyroperoxydase and thyroglobulin antibodies on the presentation and the evolution of medically treated graves’ disease

Matei Constantinescu Stefan , Hospel Julien , Daumerie Chantal , Alexopoulou Orsalia , Maiter Dominique , Burlacu Maria-Cristina

Introduction: Thyrotropin receptor stimulating antibodies (TRAb) are responsible for Graves’ disease (GD) manifestations. Other thyroid antibodies, namely thyroperoxidase (TPOAb) and thyroglobulin (TGAb) antibodies are highly prevalent in GD, but their roles in GD presentation and evolution are controversial.Methods: We retrospectively analysed TPOAb and TGAb levels and evolution in 88 consecutive patients with newly diagnosed GD between 2000 and 20...

ea0049ep1342 | Thyroid (non-cancer) | ECE2017

Immune reaction to food antigens in Graves’disease (GD) patients: role of gliadin and other food antigens

Covelli Danila , Colucci Giuseppe , Salvi Mario , Kaiser Ulrike , Eckstein Anja , Burlacu Maria Cristina , Daumerie Chantal , Richell Gez , Perros Petros , Draman Mohd Shazli , Ludgate Marian , Masetti Giulia , Biscarini Filippo

As known, an imbalance of the gut microbiota is associated with a higher risk for autoimmune diseases. Moreover the increased rates of autoimmunity reported in urban residential areas worldwide suggest a possible influence of diet. We report on the antibody response to food antigens in GD patients. Since 10% of celiac patients develop an autoimmune thyreopathy we focused on gliadin (DGP), transglutaminases (tTG) and 40 other food antigens (FA). Commercially available ELISA ass...

ea0084op-05-22 | Oral Session 5: Autoimmunity | ETA2022

Update on the role of caveolin-1 in cell homeostasis and oxidative stress in hashimoto’s thyroiditis and graves’ disease

Many Marie-Christine , Daumerie Chantal , Boschi Antonella , lelio baldeschi , Michel Mourad , Lengele Benoit , Catherine Behets , Marique Lancelot , Van Regemorter Victoria , Alexis Werion , Regemorter Elliott Van , Michael Hepp , Bournonville Marc de , Ville de Goyet Christine de , Craps Julie

Caveolin-1 (cav1) is a member of the thyroxisome multiprotein complex required for thyroid hormones synthesis which is decreased in Hashimoto’s thyroiditis (HT) and excessive in Graves’ disease (GD). Both pathologies are characterized by oxidative stress (OS), the production of reactive oxygen species (ROS) exceeding the antioxidant defenses. The aim of this study is to correlate cav1 expression and OS in HT and GD. Primary cultures of human thyrocytes were treated o...