Endocrine Abstracts

TEAMeD (Thyroid Eye Disease Amsterdam Declaration Implementation Group UK) was established in 2009 to implement the Amsterdam Declaration, which pledged to improve care for people with TED and prevent TED in those at risk. This autumn, TEAMeD is launching ‘TEAMeD-5’, a campaign to promote better care for patients with, or at risk of TED. This campaign aims to implement 5 key evidence based recommendations in endocrine clinics across the UK....

TEAMeD (Thyroid Eye Disease Amsterdam Declaration Implementation Group UK) was established in 2009 to implement the Amsterdam Declaration, which pledged to improve care for people with TED and prevent TED in those at risk. This autumn, TEAMeD is launching ‘TEAMeD-5’, a campaign to promote better care for patients with, or at risk of TED. This campaign aims to implement 5 key evidence based recommendations in endocrine clinics across the UK....

It is nearly 100 years since the discovery of insulin and insulin is still the only treatment we have for type 1 diabetes (T1D). Using and adjusting insulin therapy is very difficult and demanding for patients and rarely allows perfect blood sugar control. Even with recent advances in insulin delivery, less than 30% of patients achieve levels of HbA1c that prevent long-term complications and many of those that do regularly experience hypoglycaemia. Furthermore, a significant n...

Many processes are involved between ingesting thyroid hormone and the hormone having an effect within cells. These include hormone absorption, transport into cells, deiodination (for activation and inactivation), export from cells, receptor binding, and activation. Rare, major single gene defects have been reported at many though not all of these steps. Genome wide analyses have also identified multiple common loci associated with TSH and to lesser extent FT4 and FT...

In large community surveys, there is a consistent absolute excess of psychological caseness in subjects on thyroxine (T4) compared to age and sex matched controls of around 6%. Part of this likely to be ‘confounding by indication’ – i.e. that some individuals failed to respond to T4 as hypothyroidism was not the cause of their psychological morbidity in the first place. However, the observations that normalisation of intracellular thyroid h...

While the aetiology of Graves’ disease is now well-established, treatment for Graves’ disease has largely remained unchanged for 50 years. However, relapse rates following antithyroid drug treatment remain high, destructive therapy to the thyroid is not without its short and longer-term risks and there have been limited studies of the benefits of different treatments in terms of long-term outcomes such as cardiovascular disease. There therefore remains much room for ...

Thyroid hormone is considered the easiest hormone to replace as it can be taken orally, has a long half-life allowing once daily dosing, and serum levels can be monitored accurately using thyroid function tests. However, in repeated surveys up to 50% of patients on thyroxine do not have thyroid hormone levels in the reference range and the potential long-term consequences in terms of cardiovascular and bone health have recently been re-evaluated in large cohorts. Community sur...

We report a 41 yr old man who was found dead in his bed with a continuous glucose monitoring device in situ. He had type 1 diabetes diagnosed at age 14 years. He had poor glycaemic control during his teenage years and suffered from severe hypoglycaemic episodes and reduced hypoglycaemic awareness resulting in three road traffic accidents. His diabetes was complicated by proliferative retinopathy, nephropathy and peripheral neuropathy. He began continuous subcutaneous insulin p...

Case-1: Nineteen years old nursing student with primary hypothyroidism, despite thyroxine (T4) at 200 μg/day and subsequent trial of T4+T3, remained significantly symptomatically hypothyroid. Over 4 years worsening hypothyroidism was evident (TSH: 19.1 to >200 and fT4 2.1–6.8) despite dose/regime changes. Investigations for malabsorption: normal coeliac screen, B12, ferritin, FBC, kidney and liver function, autoimmune p...

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...