Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc6.1 | Obesity | ECE2019

Impaired glucose homeostasis in leptin-deficient ob/ob mice is corrected by AZP-3404, a 9-amino acid peptide analog derived from insulin-like growth factor-binding protein 2, a key mediator of leptin action

Culler Michael D , Delale Thomas , Milano Stephane , van der Lely Aart Jan , Abribat Thierry , Clemmons David

The key metabolic hormone, leptin, acts in part through the liver to regulate glucose homeostasis, as well as the maturation of both adipocytes and osteoblasts. These actions have been demonstrated to be mediated by insulin-like growth factor binding protein 2 (IGFBP-2), independent of its ability to bind IGF1. The effects of IGFBP-2 on adipocyte and osteoblast maturation can be localized to a short peptide sequence within the unique heparin binding domain (HBD-1) of IGFBP-2. ...

ea0063p619 | Diabetes, Obesity and Metabolism 2 | ECE2019

Trial-in-progress: ZEPHYR, a pivotal phase 2b/3 randomized, placebo-controlled study of livoletide, a novel unacylated ghrelin analog, for the treatment of hyperphagia and food-related behaviors in patients with Prader-Willi syndrome

Allas Soraya , Mohideen Pharis , Delale Thomas , Lin Vivian , Yeh Michael , Tremel Nadege , Tauber Maithe

Background: Prader-Willi syndrome (PWS) is a rare disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality and to a significant burden on patients and caregivers. There is no approved treatment for hyperphagia in PWS. Patients with PWS have increased circulating levels of the orexigenic hormone acylated ghrelin (AG) with a relative deficit of unacylated ghrelin (UAG). Livoletide (AZP-531) is a first-in-cla...

ea0073oc12.2 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Improved glucose metabolism and decreased weight gain in leptin-resistant, IGFBP2-deficient, db/db mice induced by AZP-3404, a 9-amino acid analog of IGFBP2

Culler Michael D. , Milano Stéphane , Ovize Michel , Delale Thomas , van der Lelij Aart Jan , Clemmons David

Insulin-like growth factor binding protein-2 (IGFBP2) has been demonstrated to be a key mediator of the peripheral actions of leptin, and its deficiency is associated with impaired metabolic function. The metabolic activity of IGFBP2 can be localized to a unique heparin-binding domain (HBD-1) within its structure. AZP-3404 is a 9-amino acid analog of the IGFBP2 HBD-1 that has been demonstrated to increase glucose uptake by differentiated mouse myotubes in vitro, and to increas...