Endocrine Abstracts

Introduction: Dermatomyositis is an inflammatory connective-tissue disease, characterized by inflammation of the muscles and the skin. It is more frequent among women and in 25% of cases it is related to malignancy, such as ovarian, breast, colon cancer, melanoma, non-Hodgkin’s lymphomas, lung cancer, myelo-hyperplastic syndromes, and nasopharyngeal cancer. In 1/3 of cases dermatomyositis precedes malignancy, in 1/3 they present simultaneously, and in the remaining 1/3 o...

Type 1 cannabinoid receptor (CB1) is the principal receptor for endocannabinoids in the brain which mainly occurs in preterminal/terminal axons and mediates retrograde neuronal signaling mechanisms. A large body of physiological and electrophysiological evidence indicates the critical role of CB1 in the regulation of hypothalamic functions. Conversely, the distribution of CB1-containing axons in the hypothalamus is essentially unknown. Therefore, we have analyzed the distribut...