Searchable abstracts of presentations at key conferences in endocrinology

ea0090s15.1 | Advances in reproductive endocrinology | ECE2023

Effects of kisspeptin in patients with low sexual desire?

Dhillo Waljit S

Successful reproduction in humans at a population level, is reliant on the careful co-ordination of reproductive hormones with associated behaviours. Kisspeptin is a neuropeptide that is critical for normal hypothalamic function of the reproductive hormonal axis. However beyond its hormonal effects, non-human data suggests an emerging role for kisspeptin in a range of animal behaviours through extra-hypothalamic downstream neuroendocrine pathways. Until recently, the roles of ...

ea0038pl2biog | Society for Endocrinology Medal Lecture | SFEBES2015

Society for Endocrinology Medal Lecture

Dhillo Waljit S

Professor Waljit Dhillo is a Professor in Endocrinology and Metabolism and Consultant Endocrinologist, Imperial College London. He completed his medical training at St Bartholomew’s Hospital Medical School, University of London in 1994. During this time he also completed an Intercalated BSc in Biochemistry (awarded First Class Honours) funded by the Medical Research Council. He then completed h...

ea0031p91 | Clinical practice/governance and case reports | SFEBES2013

A painful neck in a young well looking man presenting to A&E

Izzi-Engbeaya Chioma , Zac-Varghese Sagen , Palazzo Fausto , Meeran Karim , Dhillo Waljit S

A 38-year-old man presented on the acute medical take with a week’s history of sore throat, dysphagia, neck swelling, and fever. One month prior he had suffered a respiratory tract infection, which resolved without antibiotics. He had no notable past medical and family history. He was a non-smoker and drank 15 units of alcohol per week. On examination he looked well, was afebrile, sweaty and flushed; chest was clear, heart sounds were normal, regular pulse (110 bpm) and B...

ea0077p110 | Reproductive Endocrinology | SFEBES2021

Clinical characteristics associated with testosterone prescribing in men in primary care

Sharma Aditi , Ul-Haq Zia , Sindi Emad , Al-Sharefi Ahmed , Kamalati Tahereh , Dhillo Waljit S. , Minhas Sukhbinder , Jayasena Channa N

Background: Testosterone replacement therapy (TRT) is widely used for the treatment of symptomatic hypogonadism in men. However, data on prescription behaviours of TRT are limited. The objective of this study was to investigate clinical characteristics associated with the likelihood of being prescribed TRT by general practitioners (GPs) in North West London (NWL).Methods: We carried out a retrospective cohort study using Discover database of GP-registere...

ea0065oc6.1 | Reproductive Endocrinology and Biology | SFEBES2019

Effect of MVT-602, a potent kisspeptin receptor agonist, on LH levels in healthy pre-menopausal women undergoing a minimal controlled ovarian stimulation protocol

Abbara Ali , Duijkers Ingrid , Ezzati Max , Voors Christine , Romeijn Christel , Berman Lance , Fan Xiaolin , Migoya Elizabeth , Dhillo Waljit S

Background: Kisspeptin is an endogenous neuropeptide that regulates GnRH release from the hypothalamus. Kisspeptin-54 has been shown to effectively trigger oocyte maturation during in vitro fertilisation (IVF) treatment, but with markedly reduced rates of ovarian hyperstimulation syndrome (OHSS). The kisspeptin receptor agonist, MVT-602, has a longer half-life than native kisspeptin-54 (1.5–2.2 h vs. 0.5 h) and has potential for development as a novel trigger of oocyte ma...

ea0065p377 | Reproductive Endocrinology and Biology | SFEBES2019

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

Dimakopoulou Anastasia , Jayasena Channa N , Alkaabi Fatima M , Liebers Curtis S , Handley Thomas , Franks Stephen , Dhillo Waljit S

Introduction: Over half of postmenopausal women suffer symptoms which can sometimes be non-responsive to hormone replacement therapy (HRT). Testosterone is implicated in regulating urogenital and sexual function in women. However, using testosterone therapy in postmenopausal women remains highly controversial, principally due to the lack of syndromic relationship between serum testosterone levels and onset of sexual dysfunction during menopause. Clinical practice is therefore ...

ea0048o6 | Oral Communications | SFEEU2017

Using Kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea

Narayanaswamy Shakunthala , Vimalesvaran Sunitha , Yang Lisa , Prague Julia K , Miras Alexander D , Franks Stephen , Meeran Karim , Dhillo Waljit S

Case history: An 18-year-old Caucasian female presented with primary amenorrhoea after her younger sister aged 16 years old started menstruating. She had a normal childhood and progressed through puberty normally, with no past medical history or family history. BMI was 22.6 with a normal examination including secondary sexual characteristics (Tanner Stage 5) and no signs of hyperandrogenism.Investigations and Results: Bloods showed an elevated LH:FSH rat...

ea0025p318 | Thyroid | SFEBES2011

Serum phosphate predicts temporary hypocalcaemia following thyroidectomy

Sam Amir H , Dhillo Waljit S , Donaldson Mandy , Moolla Ahmad , Meeran Karim , Tolley Neil S , Palazzo Fausto

Background: Temporary hypocalcaemia occurs in up to 40% of patients following a total thyroidectomy. Serum calcium and parathyroid hormone (PTH) measurements are currently used to predict post-thyroidectomy hypocalcaemia. However, immediate access to PTH measurement is expensive and not widely available. Serum phosphate responds rapidly to changes in circulating PTH levels and its measurement is readily available in all hospitals. We evaluated the use of serum phosphate to pre...

ea0015p281 | Reproduction | SFEBES2008

Pre-analytical factors affecting measurement of plasma kisspeptin by radioimmunoassay

Ramachandran Radha , Patterson Michael , Murphy Kevin G , Dhillo Waljit S , Patel S , Kazarian A , Ghatei Mohammad A , Bloom Stephen R

Background: Kisspeptin is a peptide product of the KiSS-1 gene and a key regulator of the hypothalamo-pituitary-gonadal axis. Pregnancy is associated with raised plasma kisspeptin concentrations. However, there is significant variation in the plasma kisspeptin levels quoted in previous studies. We investigated the effects of pre-analytical factors including processing time and anticoagulant type on plasma kisspeptin-immunoreactivity (IR) measurement.Meth...

ea0077p243 | Reproductive Endocrinology | SFEBES2021

The effect of exogenous kisspeptin administration in a novel mouse model of hypothalamic amenorrhoea

Shrewsbury Jed V , Ng Kah-Yan , McIntyre Caitlin , Li Xiao Feng , Phylactou Maria , O’Byrne Kevin T , Abbara Ali , Dhillo Waljit S , Owen Bryn M

Kisspeptin is integral to hypothalamo-pituitary-gonadal (HPG) axis function and overall fertility. Functional deficiency of GnRH/lH secretion in the central reproductive disease, hypothalamic amenorrhoea (HA), indicates diminished kisspeptin signalling. Clinical trials have shown kisspeptin to be a viable therapeutic intervention. However, repeated administration led to the development of tachyphylaxis and so is likely a problem for future implementation. Indeed, elevated LH r...