Searchable abstracts of presentations at key conferences in endocrinology

ea0065p11 | Adrenal and Cardiovascular | SFEBES2019

Cosyntropin stimulation test post unilateral adrenalectomy for non-steroid secreting lesions: not all who fail require steroids

Zaman Shamaila , Almazrouei Raya , DiMarco Aimee , Palazzo Fausto , Wernig Florian

Aim: Recent studies reported a wide range in baseline and peak cortisol responses to surgery. We report the results of cosyntropin stimulation testing following unilateral adrenalectomy for non-steroid secreting lesions.Methods: Data of 36 patients who underwent cosyntropin stimulation testing on the second day post unilateral adrenalectomy were collected retrospectively. None of the patients had clinical signs of hypercortisolism. No patient received pr...

ea0081p505 | Late-Breaking | ECE2022

Primary hyperparathyroidism, familial hypocalciuric hypercalcaemia or both?

Kapoor Ashutosh , Sharma Bhavna , Sriranganathan Danujan , Tolley Neil , Dimarco Aimee , Rahman Mushtaqur

Introduction: Primary hyperparathyroidism (PHPT) is an endocrine condition in which autonomous excessive secretion of parathyroid hormone (PTH) results in hypercalcaemia. In approximately 80% of cases the aetiology is due to a single parathyroid adenoma, the remainder are due to hyperplasia of more than one gland. Familial Hypocalciuric Hypercalcaemia (FHH) is an autosomal dominant, inactivating mutation of the calcium-sensing receptor, causing a right-shift in the concentrati...

ea0094op4.1 | Thyroid | SFEBES2023

Management of thyroid nodules in patient with phosphatase and tensin homolog gene (PTEN) mutation

Yang Wei , Palazzo Fausto , Tolley Neil , Dimarco Aimee , Brady Angela , Tan Tricia

Introduction: Phosphatase and tensin homolog gene (PTEN) gene encodes a lipid phosphatase that plays a central role in cell-cycle processes. PTEN hamartoma tumour syndrome (PHTS), caused by the mutation of the PTEN gene, is a diverse multi-system disorder. PHTS is characterised by the hamartomatous growths, increased risk of breast, thyroid, and renal cancers. In terms of thyroid presentation of PHTS, there is up to 75% risk of multinodular goitre and the life...

ea0099p414 | Adrenal and Cardiovascular Endocrinology | ECE2024

Aldosterone:metanephrine ratio better predicts laterality in patients with primary aldosteronism and mild autonomous cortisol co-secretion than aldosterone:cortisol ratio

Htut Zin , Sharma Aditi , Foran Daniel , Palazzo Fausto , Dimarco Aimee , Meeran Karim , Alsafi Ali , Wernig Florian

Introduction: Adrenal Venous Sampling (AVS) is considered the gold standard to identify surgically treatable primary aldosteronism (PA) subtypes. Current guidelines suggest using plasma cortisol concentrations to confirm successful adrenal vein (AV) cannulation and lateralisation, but cortisol co-secretion by adrenal adenomas can lead to diagnostic misinterpretation. Plasma metanephrines (MN) have a half-life of 3 to 6 min and are not affected by cortisol co-secretion, and the...

ea0073aep120 | Calcium and Bone | ECE2021

An unusual case of primary hyperparathyroidism due to hyperplasia resembling tertiary hyperparathyroidism

Mantega Michele , Mateen Abdul , Azam Sultana , Sharma Bhavna , Seechurn Shivashankar , Remedios Denis , Moonim Mufaddal , DiMarco Aimee , Rahman Mushtaqur

Primary hyperparathyroidism is a common endocrine condition; 80% due to a parathyroid adenoma. We present an unusual case of a 69-year old white European female, who presented first in 2012 with mild hypercalcaemia (< 2.8 mmol/l), osteoporosis, hypertension and type 2 diabetes. Pharmacotherapy included Bendroflumethiazide, but no phosphate supplements. Investigations revealed primary hyperparathyroidism and dual-modality scanning showed no evidence of an adenoma, although ...

ea0086oc2.4 | Endocrine Cancer and Late Effects | SFEBES2022

Delta-like non-canonical Notch ligand 1 (DLK1) – a novel biomarker in adrenocortical carcinoma

Pittaway James , Mariniello Katia , Altieri Barbara , Sbiera Iuliu , Sbiera Silviu , Chung Teng-Teng , Abdel-Azziz Tarek , DiMarco Aimee , Palazzo Fausto , Akker Scott A. , Landwehr Laura-Sophie , Ronchi Cristina , Parvanta Laila , Drake William , Kroiss Matthias , Fassnacht Martin , Guasti Leonardo

Adrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options and a heterogenous prognosis. The histological diagnosis of ACC is complex and there is increasing interest in identifying and validating new immunohistochemical markers. Delta-like non-canonical Notch ligand 1 (DLK1) is a cleavable single-pass transmembrane protein. In humans, DLK1 is present in many tissues during foetal development, is restricted to progenitor/stem cells in a few adult tissue...