Searchable abstracts of presentations at key conferences in endocrinology

ea0027p39 | (1) | BSPED2011

Treatment strategies and outcomes of paediatric Craniopharyngioma since 2005: a single centre experience

Upadrasta Swathi , Doss Arun , Mallucci Conor , Pizer Barry , Abernethy Laurence , Das Urmi , Dharmiaj Poonam , Didi Mohamed , Blair Jo

Background: The Craniopharyngioma service in our centre has changed since 2005 with a standardised preoperative assessment and a new approach to surgery and use of radiotherapy. We review the subsequent outcomes.Treatment strategy: Preoperative endocrinology: prior to dexamethasone therapy: standard dose short synacthen test (SST), thyroid function test (TFT), IGF1, LH, FSH, testosterone/oestradiol±GH stimulation test. Staging: MRI and tumour stagin...

ea0085p45 | Pituitary and Growth 1 | BSPED2022

The use of 6-monthly GnRH analogues in the paediatric population

Apperley Louise , Dharmaraj Poonam , Blair Joanne , Ramakrishnan Renuka , Das Urmi , Didi Mohamed , Laing Peter , Yung Zoe , Cassidy Kelly , Blundell Pauline , Jarvis Charlotte , Parkinson Jennifer , Senniappan Senthil

Background: Pubertal progression is inhibited in central precocious puberty with the use of gonadotropin releasing hormone (GnRH) analogues. They are usually given every 10 to 12 weeks via an intramuscular depot, but more recently, a 6-monthly preparation has become available for clinical use.Aim: The aim of this project was to evaluate the efficacy and acceptability of 6-monthly triptorelin, a GnRH analogue, at a tertiary children’s hospital.<p...

ea0027p32 | (1) | BSPED2011

Steroid dose, age and gender affect adrenal responses to a low dose short Synacthen test in children with asthma

Hawcutt Daniel , Jorgensen Andrea , Gardner Christopher , Peak Matthew , Couriel Jonathan , Lacy David , Newland Paul , Didi Mohamed , Pirmohamed Munir , Smith Rosalind , Blair Joanne

Background: The activity of the hypothalamic–pituitary–adrenal axis (HPA) during inhaled corticosteroid (ICS) treatment of asthma has been studied extensively. To date patient populations have been too small or homogeneous to identify relationships between steroid exposure, patient characteristics and HPA activity. In this abstract we report data from a large, heterogeneous cohort of patients recruited to observational and pharmacogenomic studies.<p class="abstex...

ea0045p9 | Bone | BSPED2016

The use of Bone Health Index standard deviation score (BHI-SDS) in the analysis of cohorts with constitutional delay of growth (CGP), Growth Hormone deficiency (GHD), Turners syndrome (TS) and congenital adrenal hyperplasia (CAH)

Park Julie , Alsaffar Hussain , Frerichs Carley , Parvatti Prashant , Dharmaraj Poonam , Das Urmi , Didi Mohamed , Ramakrishnan Renuka , Senniappan Senthil , Abernethy Laurence , Blair Jo

Background: BoneXpert software calculates bone health index (BHI) from 100 measurements of cortical thickness and mineralisation of three metacarpals. BHI-SDS is derived from 3,121 X-rays from 231 healthy Caucasian children, corrected for bone age (BA), estimated from the same x-ray.BHI-SDS is new with relatively unknown clinical utility. Strong correlations between BHI and dual-energy x-ray (DXA) absorptiometry and peripheral quantitative computed CT me...