Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep998 | Pituitary - Clinical | ECE2017

Ipilimumab-induced hypophysitis

Selfa Silvia Maria Maraver , Vega Maria Molina , Molero Inmaculada Gonzalez , Doblas Isabel Mancha , Madueno Francisco Tinahones

Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...

ea0037ep893 | Thyroid cancer | ECE2015

Thyroid cancer arises in 5% of patients referred from primary care to a high-resolution thyroid clinic

Doblas Isabel Mancha , Cortes-Salazar Carmen Maria , Fernandez-Garcia Jose Carlos , Tinahones Francisco

Objective: To evaluate the prevalence of thyroid cancer in patients with suspected thyroid nodule referred from primary care.Methods: Retrospective cohort study which included patients with suspected thyroid nodule referred from primary care to a high-resolution thyroid nodule clinic. Demographic and clinical characteristics were collected, all patients underwent thyroid ultrasound and subsequently, a fine-needle aspiration (FNA) was performed if thyroid...

ea0035p210 | Clinical case reports Pituitary/Adrenal | ECE2014

Diabetes insipidus and hypopituitarism in a patient with idiopathic pulmonary fibrosis

Selfa Silvia Maraver , Garach Araceli Munoz , Cesar Maria Jose Picon , Doblas Isabel Mancha , Madueno Francisco Tinahones

Diabetes insipidus is a disease characterized by the inability to concentrate urine. The common form is central diabetes insipidus (CDI) caused by a lack of AVP after destruction of supraoptic–paraventricular nuclei. Further investigations are needed to establish its cause.: Case reportA 38-year-old woman presented with prompt polyuria–polydipsia. She has been taking contraceptive tablets for 2 years, smoked four to five cigarettes per day....

ea0056p894 | Clinical case reports - Thyroid/Others | ECE2018

Postmenopausal virilization with negative imaging

Vega Maria Molina , Doblas Isabel Mancha , Pareja Isabel Cornejo , Garach Araceli Munoz , Selfa Silvia Maraver , Madueno Francisco Tinahones

Introduction: After menopause, an abrupt drop in estrogen levels happens, while ovary androgens secretion declines gradually with aging. This relative hyperandrogenism may lead to the development of hyperandrogenic symptoms. However, the development of marked hirsutism and/or symptoms/signs of virilization, make necessary a detailed study in order to rule out tumorous cause (from adrenal glands or ovaries).Case report: 58 years old woman with progressive...

ea0037ep718 | Pituitary: clinical | ECE2015

Pituitary adenoma of aggressive behaviour

Selfa Silvia Maraver , Perez Ana Gomez , Doblas Isabel Mancha , Pareja Isabel Maria Cornejo , Vega Maria Molina , Perdigones Cristina Diaz , Madueno Francisco Tinahones

Pituitary ACTH-secreting tumour presents with variety of clinical features: normal cortisol secretion and ACTH-immunopositive staining and mild hypercortisolism without typical features of Cushing’s disease. We present a 53-year-old male with history of hypertension. First visit (2005): visual loss, bitemporal hemianopsia in campimetry and in MRI pituitary adenoma (2.5 cm) invading cavernous sinus and suprasellar cister. Hormonal study supported panhypopituitarism. After ...

ea0037ep1169 | Clinical Cases–Pituitary/Adrenal | ECE2015

Oncocytic adrenal cortical adenoma presenting as Cushing's syndrome: an exceptional clinical entity

Vega Maria Molina , Garach Araceli Munoz , Selfa Silvia Maraver , Perez Ana Gomez , Pareja Isabel Cornejo , Perdigones Cristina Diaz , Doblas Isabel Mancha , Madueno Francisco Tinahones

Introduction: Oncocytomas are tumours composed by oncocytes, cells with granular and eosinophilic cytoplasm filled with mitochondria. It is a neoplasm that can arise in several organs (more commonly described in the kidney, salivary gland and thyroid). Oncocytoma arising in the adrenal gland is a rare finding. Most of them are benign and non-functioning and are detected incidentally. However, functional adrenal oncocytomas presenting as Cushing’s syndrome and phaeochromoc...

ea0081ep1021 | Thyroid | ECE2022

Clinical experience with tyrosine kinase inhibitors in radioiodine-refractory differentiated thyroid cancer

Fernandez Valero Andrea , Damas-Fuentes Miguel , Montoro Jose Ignacio Marti nez , Vega Maria Molina , Doblas Isabel Mancha , Garcia Aleman Jorge , Ochoa Arantzazu Sebastian , Manuel Trigo Perez Jose , Jose Tinahones Madueno Francisco

Introduction: Differentiated thyroid cancer (DTC) represent 85- 90 % of all thyroid cancer cases. Most of these have an excellent prognosis with standard treatment. However, between 7 and 23% will develop distant metastases and, of these, more than 65% will become radioactive iodine-refractory. In some of these patients who are considered to be radioiodine-refractory with rapidly progressive or symptomatic disease, or in patients who are not candidates for other therapies, the...

ea0037ep483 | Diabetes (complications & therapy) | ECE2015

Once-weekly exenatide in a real-world clinical setting: clinical outcomes and analysis of potential predictors of response

del Mar Roca-Rodriguez Maria , Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , Moya-Carmona Isabel , Gomez-Perez Ana Maria , Cornejo-Pareja Isabel , Munoz-Garach Araceli , Molina-Vega Maria , Doblas Isabel Mancha , Tinahones Francisco

Objective: The aim of this study is to evaluate the effectiveness of once-weekly exenatide on metabolic control, weight, blood pressure, and lipid profile in obese patients with type 2 diabetes (T2DM), and to assess possible predictive factors of response.Material and methods: Retrospective observational study, conducted with adult obese (BMI ≥30 kg/m2) T2DM subjects that had been initiated once-weekly exenatide following routine clinica...