Searchable abstracts of presentations at key conferences in endocrinology

ea0068oc2 | Abstracts | UKINETS2019

Development of ex-vivo models of metastatic neuroendocrine neoplasms

Doornebal Ewald , Harris Nicola , Edwards Helen , Miquel Rosa , Zen Yoh , Pizanias Michail , Prachalias Andreas , Menon Krishna , Zamalloa Ane , Preziosi Melissa , Heaton Nigel , Ramage John K , Williams Roger , Palma Elena , Chokshi Shilpa , Srirajaskanthan Raj

Background: The lack of relevant in-vivo and in-vitro models has precluded investigations of the pathophysiology of metastatic NENs. Organotypic tumour slices retain the complexity of tumours in-vivo without extensive manipulation of the tissue. The aims of this study are to understand the utility of precision cut slice technology to develop an immunocompetent model of metastatic GEP NENs to test new therapeutics and elucidate immunological, molecula...

ea0072oc1 | Oral Communications | UKINETS2020

Identification of soluble immune checkpoint receptor landscape in liver metastases of neuroendocrine neoplasms: A new perspective for immunotherapy

Doornebal Ewald , Harris Nicola , Riva Antonio , Pizanias Michail , Phillips Sandra , Zen Yoh , Sticova Eva , Prachalias Andreas , Menon Krishna , Zamalloa Ane , Preziosi Melissa , Heaton Nigel , Eaton Simon , Ramage John , Williams Roger , Palma Elena , Srirajaskanthan Rajaventhan , Chokshi Shilpa

Accumulating evidence suggests that the immunological landscape plays a key role in the progression of neuroendocrine liver metastases (LM-NENs), which is often characterised by immune cell infiltration. Anti-tumour functions of infiltrating lymphocytes are often silenced through hyper-expression of inhibitory checkpoint receptors (CRs) such as PD-1, but favourable outcomes with anti-PD-1 therapy have been low. Recently, functional soluble (cell-free) CRs beyond PD-1 have been...