Searchable abstracts of presentations at key conferences in endocrinology

ea0050ep109 | Thyroid | SFEBES2017

Thymic hyperplasia associated with Graves’ disease: could thymic surgery be deleterious?

Gheorghiu Monica Livia , Magheran Elena , Matura Teodora , Dumitrascu Anda

Thymic hyperplasia is frequent in patients with Graves’ disease (GD) but it rarely is large enough to be detected radiologically as an anterior mediastinal mass. In the few cases operated, lymphoid hyperplasia (i.e. lymphoid follicle proliferation with expansion of both the cortical and the medullary component) has been documented histologically in 38% of cases, while true thymic hyperplasia, i.e. thymic enlargement with normal tissue architecture, was found...

ea0050ep109 | Thyroid | SFEBES2017

Thymic hyperplasia associated with Graves’ disease: could thymic surgery be deleterious?

Gheorghiu Monica Livia , Magheran Elena , Matura Teodora , Dumitrascu Anda

Thymic hyperplasia is frequent in patients with Graves’ disease (GD) but it rarely is large enough to be detected radiologically as an anterior mediastinal mass. In the few cases operated, lymphoid hyperplasia (i.e. lymphoid follicle proliferation with expansion of both the cortical and the medullary component) has been documented histologically in 38% of cases, while true thymic hyperplasia, i.e. thymic enlargement with normal tissue architecture, was found...

ea0067gp10 | Poster Presentations | EYES2019

Advanced metastatic sporadic medullary thyroid carcinoma: a case of thirty-year survival with progressive disease

Sorohan Madalina , Dusceac Roxana , Dumitrascu Anda , Poiana Catalina

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid neoplasm with a high degree of malignancy derived from the parafollicular calcitonin-secreting cells. This carcinoma may occur sporadically in about 80% of cases or it may be part of the autosomal dominant multiple endocrine neoplasia (MEN) type 2. While the 10-year survival rate is around 40–75%, for metastatic disease, it’s just below 20%.Case presentation: We report the case of ...

ea0063p277 | Pituitary and Neuroendocrinology 1 | ECE2019

Gross total versus incomplete resection of craniopharyngioma in adults

Capatina Cristina , Dumitrascu Anda , Caragheorgheopo Andra , Ciubotaru Vasilie , Poiana Catalina

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the postsurgical evolution of craniopharyngioma in adults after total or incomplete surgical resection.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Buc...

ea0063p788 | Thyroid 2 | ECE2019

Riedl thyroiditis associated with intense cervical pain

Verdes Andreea , Capatina Cristina , Dumitrascu Anda , Ioachim Dumitru

Introduction: Riedl thyroiditis is a rare thyroid disorder of unknown etiology (autoimmune assumed), in which the gland is invaded by dense fibrous tissue, that extends in the vicinity. Goiter is usually painless and can be accompanied by other fibrous affections (retroperitoneal fibrosis, sclerosing cholangitis, mediastinal fibrosis).Case presentation: Patient, 39 years old, smoker, from nonendemic area, initially presents in 2011 with voluminous polyno...

ea0049ep352 | Paediatric endocrinology | ECE2017

Progressive osseous heteroplasia in a child with pseudohypoparathyroidism type I

Vintila Madalina , Gherlan Iuliana , Dumitrescu Cristina , Dumitrascu Anda , Procopiuc Camelia

Introduction: Progressive osseous heteroplasia (POH) is a rare genetic condition of progressive heterotopic ossification (HO), from skin and subcutaneous tissues into deep skeletal muscles. Most cases are caused by heterozygous inactivating mutations of GNAS gene. Related disorders are Albright hereditary osteodystrophy (AHO), pseudohypoparathyroidism (PHP), and primary osteoma cutis. Distinction from other GNAS-based conditions is made by the extension of HO from superficial ...

ea0049ep911 | Neuroendocrinology | ECE2017

Increased morbidity associated with the treatment of craniopharyngioma

Capatina Cristina , Dumitrascu Anda , Caragheorgheopol Andra , Poiana Catalina

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the posttreatment evolution of craniopharyngioma in children and adults in a large mixed cohort.Material and Methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest ...

ea0044p153 | Neuroendocrinology and pituitary | SFEBES2016

Clinical and radiological presentation of craniopharyngioma in a mixed cohort of children and adult patients

Capatina Cristina , Bodnarescu Mihaela , Dumitrascu Anda , Caragheorgheopol Andra , Poiana Catalina

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the potential differences in the clinical and radiological presentation of craniopharyngioma in children versus adults in a large mixed cohort.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the Na...

ea0041ep283 | Clinical case reports - Pituitary/Adrenal | ECE2016

Long-term remission (cure?) of acromegaly after discontinuation of somatostatin analogs

Gheorghiu Monica Livia , Vargatu Iulia , Dumitrascu Anda , Caragheorgheopol Andra

In acromegaly, treatment with somatostatin analogs (SSA) normalizes growth hormone (GH) and insulin-like growth factor 1 (IGF1) secretion in about half of the patients. Usually, the disease relapses biochemically within few months after treatment withdrawal.We present two acromegalic patients, women of 49 and 53 years at diagnosis, respectively, who achieved stable remission of the disease after medical treatment withdrawal. One had a microadenoma, the o...

ea0041ep1066 | Thyroid (non-cancer) | ECE2016

Hypertrophic Hashimoto’s thyroiditis mimicking thyroid lymphoma

Alexandru Niculescu Dan , Iorgulescu Radu , Dumitrascu Anda , Poiana Catalina

Introduction: Hashimoto’s thyroiditis (HT) is a well known risk factor for thyroid lymphoma. A rapidly enlarging goiter accompanied by lymph nodes pressure on surrounding structures usually suggest the development of thyroid lymphoma.Case report: An 85 years old hypertensive women presented for a massive goiter extending from the lower jaw to clavicle which increased in size for the last 5 months. She also complained of dysphagia, hoarseness and sho...