Endocrine Abstracts

The FRAXÒ algorithm represented a major step forward in absolute fracture risk assessment. It took advantage of globally derived information to predict fracture risk that used that as the basis for rational treatment recommendations for a large proportion of the international community. The extrapolation of FRAXÒ to different regional and geographic criteria has been based on two sets of data that can be obtained with relatively high accuracy; these being regional ag...

Objectives: Little is known about the mechanisms responsible for improvement in insulin resistance after bariatric surgery. We examined the impact of three types of bariatric surgery, in comparison with dietary intervention (DIET) on concurrent changes in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and appetite hormones over the period of 3 years. We also investigated the weight loss independent hormonal effects on insulin resistance.Me...

Although bariatric surgery is the most effective weight loss therapy, its skeletal consequences are unclear. The aim of this study was to assess the impact of weight loss, gut hormones, adiponectin on bone loss in people undergoing Dieting (Diet), Gastric Banding (GB) and Gastric Sleeve (GS) over 24 months post-intervention.There were 15 Diet, 8 GB and 20 GS subjects with mean (±S.D.) age 53 (12) years and BMI 39 (6). At 12 months mea...