Endocrine Abstracts

Nonclassical Congenital Adrenal Hyperplasia (NCAH) usually due to 21 Hydroxylase deficiency (21OHD) is an autosomal recessive disease, occurring in upto 1/200 of Caucasians and more often in certain ethnic groups. Common CYP21A2 mutations from most severe to mildest are; null, I2 splice, I172N, P30L, and V281L. Mutations leaving 20–70% of enzyme activity is responsible for NCAH, mostly caused by V281L mutation. About 25–50% of patients are homozygous or compound hete...

Case: A 28-year old man was admitted to our hospital with complaints of three days of severe headache, diplopia and ptosis of the right eye. He had pituitary macroadenoma and had been on cabergolin 0.25 mg/week for the last six months. At physical examination, he demonstrated ptosis and inability to move the right eye medially. Magnetic resonance imaging showed a 13×12 mm pituitary mass with suprasellar extension and hemorrhage. Visual field analysis was abnormal except t...

Introduction: Radiotherapy to the head and neck area is the standard therapy used for the treatment of nasopharyngeal carcinoma. Hypopituitarism is a well-known late complication of cranial radiotherapy. Although very rarely, it may be observed following radiotherapy to the head and neck area, as well.Case report: A 53-year-old man was referred to our endocrinology department for hyponatremia and low free thyroxine (T4) with normal thyroid- st...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy that affects 5–10% of women of reproductive age. It is now recognized as not only a reproductive but also a metabolic disorder with co-morbidities, such as; diabetes, dyslipidemia, hypertension, etc. All these metabolic abnormalities predispose women with PCOS to atherosclerosis. Plasma viscosity is a major determinant of blood flow in microcirculation. Preliminary data indicate that elevated plasma...

Background: In the literature there are rare cases of patients with known Type 2 Diabetes Mellitus whom are diagnosed as insulinoma. However a synchronous diagnosis with insulinoma and diabetes for a patient presenting with hypoglycemia symptoms is not an expected condition.Case: A 79 years-old female patient was sent to our Endocrinology outpatient clinic because of repeating minor and major hypoglycemia attacks. She had no important finding in her back...

Background: Autoimmune pancreatitis (AIP) is a relatively new entity in which the exocrine pancreas shows lymphocytic infiltration. There are two subtypes of AIP; Type 1 related with Immunoglobulin G4 (IgG4) as the pancreatic manifestation of IgG4-related disease (IgG4-RD), and Type 2 related with granulocytic infiltration. The characteristic features of Type 1 AIP are increased serum IgG4 levels, lymphoplasmacytic sclerosing pancreatitis (infiltration of IgG4+ plasmacytes and...

Background: Acromegaly is a rare neuroendocrine disorder caused by secretion of excessive levels of growth hormone. Somatostatin receptor ligands (SRLs) are first-line medical therapies for patients in whom surgery has failed or is contraindicated. We report a case who had inadequate response to multiple therapies including surgery,radiotherapy,octreotide,lanreotide,cabergoline and pegvisomant.Case: An 44-year-old woman was admitted to our hospital with ...

Objectives: Detection rate of thyroid nodules is increasing with use of new imaging modalities, like 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To avoid unnecessary operations, differentiating between benign and malignant 18F-FDG PET/CT-positive thyroid nodules is essential. Many authorities recommend fine needle aspiration biopsy (FNAB) for exclusion of malignancy in thyroid nodules. Although FNAB is a simple, easily performed proc...

We aimed to observe the association between degree of obesity and metabolic syndrome and plasma thyrotropin levels in obese, euthyroid patients. 947 obese and overweight patients who admitted to our outpatient clinic were assessed retrospectively. 150 healthy euthyroid cases were also recruited as the control group. Cases with metabolic syndrome were determined. Patients were divided into various subgroups as overweight, obese, morbid obese, men, and women. No statistical sign...

Objective: SAGIT, a new instrument designed for therapeutic decision, is not routinely used yet. While the medical treatment was mostly planned according to disease activity by hormonal evaluation, the therapeutic decision has tried to be standardized with the SAGIT instrument. The aim of this study is to reassess the therapeutic decisions by clinicians in the management of acromegaly according to the SAGIT instrument.Material and Method: This multicente...